Results 61 to 70 of about 431,319 (321)

Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus

Frontiers in Genetics, 2022
Background: Metformin has been proven to have an antiaging effect. However, studies on how metformin affects global epigenetic regulation and its effect on the epigenetic clock in diabetes mellitus (DM) patients are limited.
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
doaj   +1 more source

Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort [PDF]

, 2019
Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation ...
Banszerus, Verena L., Demuth, Ilja, König, Maximilian, Salewsky, Bastian, Vetter, Valentin M.   +4 more
core   +1 more source

The Circadian Clock, the Immune System, and Viral Infections: The Intricate Relationship Between Biological Time and Host-Virus Interaction [PDF]

, 2020
Living beings spend their lives and carry out their daily activities interacting with environmental situations that present space-time variations and that involve contact with other life forms, which may behave as commensals or as invaders and/or ...
Carbone, Annalucia, Mazzoccoli, Gianluigi, Relógio, Angela, Vinciguerra, Manlio   +3 more
core   +1 more source

Age prediction of green turtles with an epigenetic clock

Molecular Ecology Resources, 2022
Age is a fundamental life history attribute that is used to understand the dynamics of wild animal populations. Unfortunately, most animals do not have a practical or nonlethal method to determine age.
Benjamin Mayne, W. Mustin, Vandanaa Baboolal, F. Casella, Katia Ballorain, M. Barret, M. Vanderklift, A. Tucker, D. Korbie, S. Jarman, O. Berry   +10 more
semanticscholar   +1 more source

Epigenetic clock and methylation studies in the rhesus macaque. [PDF]

Geroscience, 2021
AbstractMethylation levels at specific CpG positions in the genome have been used to develop accurate estimators of chronological age in humans, mice, and other species. Although epigenetic clocks are generally species-specific, the principles underpinning them appear to be conserved at least across the mammalian class.
Horvath S, Zoller JA, Haghani A, Jasinska AJ, Raj K, Breeze CE, Ernst J, Vaughan KL, Mattison JA.   +8 more
europepmc   +9 more sources

Accelerated epigenetic aging in Werner syndrome. [PDF]

, 2017
Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased ...
Flunkert, Julia, Haaf, Thomas, Horvath, Steve, Maierhofer, Anna, Martin, George M, Oshima, Junko   +5 more
core   +1 more source

Epigenetic clock and methylation studies in vervet monkeys. [PDF]

Geroscience, 2022
ABSTRACTDNA methylation-based biomarkers of aging have been developed for many mammals but not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human primate model for biomedical studies. We generated novel DNA methylation data from vervet cerebral cortex, blood, and liver using highly conserved mammalian CpGs represented on a ...
Jasinska AJ, Haghani A, Zoller JA, Li CZ, Arneson A, Ernst J, Kavanagh K, Jorgensen MJ, Mattison JA, Wojta K, Choi OW, DeYoung J, Li X, Rao AW, Coppola G, Freimer NB, Woods RP, Horvath S.   +17 more
europepmc   +8 more sources

Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination

Frontiers in Genetics, 2022
The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence suggest that severe COVID-19 is associated with durable scars to the epigenome.
Alina P. S. Pang, Albert T. Higgins-Chen, Albert T. Higgins-Chen, Florence Comite, Florence Comite, Ioana Raica, Christopher Arboleda, Hannah Went, Tavis Mendez, Michael Schotsaert, Michael Schotsaert, Varun Dwaraka, Ryan Smith, Morgan E. Levine, Lishomwa C. Ndhlovu, Michael J. Corley   +15 more
doaj   +1 more source

Epigenetic Clock Acceleration Is Linked to Age at Onset of Parkinson's Disease

Movement Disorders, 2022
Aging is the strongest risk factor for Parkinson's disease (PD), which is a clinically heterogeneous movement disorder with highly variable age at onset. DNA methylation age (DNAm age) is an epigenetic clock that could reflect biological aging.
Xuelin Tang, P. Gonzalez-Latapi, C. Marras, N. Visanji, Wanli Yang, C. Sato, A. Lang, E. Rogaeva, Ming Zhang   +8 more
semanticscholar   +1 more source

Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity

GeroScience, 2023
Abstract Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than ...
Dec, Eric, Clement, James, Cheng, Kaiyang, Church, George M., Fossel, Michael B., Rehkopf, David H., Rosero-Bixby, Luis, Kobor, Michael S., Lin, David TS., Lu, Ake T., Fei, Zhe, Guo, Wei, Chew, Yap Ching, Yang, Xiaojing, Putra, Sulistyo E. Dwi, Reiner, Alex P., Correa, Adolfo, Vilalta, Adrian, Pirazzini, Chiara, Passarino, Giuseppe, Monti, Daniela, Arosio, Beatrice, Garagnani, Paolo, Franceschi, Claudio, Horvath, Steve   +24 more
openaire   +6 more sources