Results 71 to 80 of about 431,319 (321)
DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]
, 2018 DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola +3 more
core +1 more source
Alcoholism: Clinical and Experimental Research, 2022 Background Assessing the effect of alcohol consumption on biological age is essential for understanding alcohol use‐related comorbidities and mortality.
Xiaoyu Liang +5 more
semanticscholar +1 more source
A Novel Loop: Mutual Regulation Between Epigenetic Modification and the Circadian Clock
Frontiers in Plant Science, 2019 In response to periodic environmental fluctuations generated by the rotation of the earth, nearly all organisms have evolved an intrinsic timekeeper, the circadian clock, which can maintain approximate 24-h rhythmic oscillations in biological processes ...
Shenxiu Du +3 more
doaj +1 more source
DNA methylation age is accelerated in alcohol dependence. [PDF]
, 2018 Alcohol dependence (ALC) is a chronic, relapsing disorder that increases the burden of chronic disease and significantly contributes to numerous premature deaths each year.
Hlady, Ryan A +8 more
core +2 more sources
Epigenetic clocks and programmatic aging
Ageing Research Reviews, 2023 The last decade has seen remarkable progress in the characterization of methylation clocks that track biological age in humans and many other mammalian species. While the biological processes of aging that underlie these clocks have remained unclear, several clues have pointed to a link to developmental mechanisms.
David Gems +2 more
openalex +3 more sources
Menopause accelerates biological aging [PDF]
, 2016 Although epigenetic processes have been linked to aging and disease in other systems, it is not yet known whether they relate to reproductive aging. Recently, we developed a highly accurate epigenetic biomarker of age (known as the “epigenetic clock ...
Absher, D +18 more
core +1 more source
Circadian clock: linking epigenetics to aging [PDF]
Current Opinion in Genetics & Development, 2014 Circadian rhythms are generated by an intrinsic cellular mechanism that controls a large array of physiological and metabolic processes. There is erosion in the robustness of circadian rhythms during aging, and disruption of the clock by genetic ablation of specific genes is associated with aging-related features.
Orozco-Solis, Ricardo +1 more
openaire +5 more sources
Organellar carbon metabolism is co-ordinated with distinct developmental phases of secondary xylem [PDF]
, 2019 Subcellular compartmentation of plant biosynthetic pathways in the mitochondria and plastids requires coordinated regulation of nuclear encoded genes, and the role of these genes has been largely ignored by wood researchers. In this study, we constructed
Fierro Gutierrez, Ana Carolina Elisa +4 more
core +2 more sources
Neurobiology of Stress, 2021 Background: Studies reporting accelerated ageing in children with affective disorders or maltreatment exposure have relied on algorithms for estimating epigenetic age derived from adult samples.
Felix Dammering +11 more
doaj
DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging. [PDF]
, 2020 Background & aimsThe epithelia of the intestine and colon turn over rapidly and are maintained by adult stem cells at the base of crypts. Although the small intestine and colon have distinct, well-characterized physiological functions, it remains ...
Coppola, Giovanni +5 more
core