Results 181 to 190 of about 1,306,054 (295)

Epigenetic drugs in cancer therapy: mechanisms, immune modulation, and therapeutic applications. [PDF]

Mol Biomed
Ma C, Cheng J, Gu J, Wang Q.
europepmc   +1 more source

National Drugs Advisory Board annual report, 1986

, 1986
The National Drugs Advisory Board was established by the Minister for Health in 1966 by the National Drugs Advisory Board (Establishment) Order 1966 (5.1. No. 163·of 1966) under the Health (Corporate Bodies) Act 1961.
National Drugs Advisory Board (NDAB)
core  

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Epigenetic drugs against human DNA viruses and retroviruses. [PDF]

Antiviral Res
Jurado A, Guo H, Schang LM.
europepmc   +1 more source

Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing

, 2023
Schep R, Trauernicht M, Morris B, Vergara X, Beijersbergen RL, Steensel Bv.   +5 more
europepmc   +1 more source

Epigenetic drug therapy in the treatment of colorectal cancer

, 2018
Colorectal cancer (CRC) is one of the most common cancers with a high rate of morbidity and mortality worldwide. The incidence of CRC is similar in men and women but is distributed uniformly globally.
Reza Jafarzadeh Esfehani (16267037), Sima Seifi (16265525), Seyed Mahdi Hassanian (16040378), Majid Ghayour-Mobarhan (631889), Majid Khazaei (14501567), Gordon Ferns (4464037), Maryam Ghandehari (1955554), Mehrdad Moetamani-Ahmadi (16248563), Seyed Mostafa Parizadeh (16265516), Seyed Mohammad Reza Parizadeh (16150067), Amir Avan (121170)   +10 more
core  

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

Effective Non-Invasive Delivery of Epigenetic Drugs Using Functionalized Accessory Unit Conjugates. [PDF]

Pharmaceutics
Tashima T.
europepmc   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Erratum: Antimetastatic Effect of Epigenetic Drugs, Hydralazine and Valproic Acid, in Ras-Transformed NIH 3T3 Cells [Corrigendum]. [PDF]

Onco Targets Ther, 2022
europepmc   +1 more source