Results 141 to 150 of about 181,163 (261)

Chemical epigenetic modification uncovers new isocoumarins from the endophyte <i>Dothideomycetes</i> sp. BMC-101. [PDF]

RSC Adv
Cong Y, Wang H, Wang H, Jiang J, Li L, Wu R, Zhang Y, Huo Q, Zhu M.   +8 more
europepmc   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Genetic and Epigenetic Modification of MLH1 [PDF]

The American Journal of Pathology, 2000
Manuel Perucho, Shannon A. Kuismanen, Mari T. Holmberg, Reijo Salovaara   +3 more
openaire   +2 more sources

m6A epigenetic modification of viral RNA is critical for the transmission cycle of mosquito-borne flaviviruses. [PDF]

Proc Natl Acad Sci U S A
Zhang Y, Zhu L, Yan Y, Yuan F, Wen D, Fu H, Zhang YE, Zheng A.   +7 more
europepmc   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

<i>Ngn3</i> Regulates Differentiation Competence of Retinal Progenitor Cells Through Transcriptional and Epigenetic Modification. [PDF]

Int J Mol Sci
Chen C, Liang H, He Q, Chen S.
europepmc   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

PAX8 controls proximal tubule epithelial identity and stress response through epigenetic modification of distal regulatory elements. [PDF]

J Biol Chem
Telang AC, Wan M, Orban SK, Stahlecker J, Ference-Salo JT, Delker DA, Shillingford JM, McElliott MC, Laszczyk AM, Vashi RN, Parolia A, Nguyen AL, Snyder RJ, Dressler GR, Watts JA, Beamish JA.   +15 more
europepmc   +1 more source

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

Advanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li, Kelly Yichen Li, Chiara Nicoletti, Stephen Kwok‐Wing Tsui, Pier Lorenzo Puri, Qin Cao, Kevin Y. Yip   +6 more
wiley   +1 more source

MYSM1-mediated epigenetic modification dysregulation leads to immunosuppression and secondary infections in sepsis. [PDF]

PLoS Pathog
Xiong J, Cheng X, Xiong X, Zhang H, An Q, Li Z, Fan H, Li G, Li W, Tian M, Lv J.   +10 more
europepmc   +1 more source