Epigenetic Drugs and Their Immune Modulating Potential in Cancers [PDF]
Biomedicines, 2022 Epigenetic drugs are used for the clinical treatment of hematologic malignancies; however, their therapeutic potential in solid tumors is still under investigation.
Yingying Liang, Sevin Turcan
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Epigenetic Drugs Splitomicin, Suberohydroxamic Acid, CPTH6, BVT-948, and PBIT Moderate Fibro-Fatty Development in Arrhythmogenic Cardiomyopathy [PDF]
BiomoleculesArrhythmogenic cardiomyopathy (ACM) is a cardiac disorder manifesting through electrical and contractile dysfunction of the ventricles, characterized by fibro-fatty substitution of the myocardium.
Melania Lippi +7 more
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Epigenetic drugs induce the potency of classic chemotherapy, suppress post-treatment re-growth of breast cancer, but preserve the wound healing ability of stem cells [PDF]
Cancer Biology & Therapy, 2022 Epigenetic therapy augments neoadjuvant chemotherapy (NACT) in breast cancer and may aid post-surgical wound healing affected by NACT. Our study investigates: (1) The cytotoxicity of classic paclitaxel chemotherapy on triple negative breast cancer (TNBC)
Andrew Zheng +5 more
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Novel insights into cancer stem cells targeting: CAR-T therapy and epigenetic drugs as new pillars in cancer treatment [PDF]
Frontiers in Molecular Medicine, 2023 Cancer stem cells (CSCs) represent the most aggressive subpopulation present in the tumor bulk retaining invasive capabilities, metastatic potential and high expression levels of drug efflux pumps responsible for therapy resistance.
Veronica Veschi +2 more
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Traditional Chinese Medicine: A Class of Potentially Reliable Epigenetic Drugs [PDF]
Frontiers in Pharmacology, 2022 Epigenetic modification, especially DNA methylation, plays a nonnegligible role in the occurrence and development of tumors. Increasing studies are indicating that traditional Chinese medicine (TCM) plays a considerable anti-tumor role by regulating the ...
Daoqi Zhu, Aiwu Li, Ying Lv, Qin Fan
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Epigenetic drugs for cancer treatment and prevention: mechanisms of action
Biomolecular Concepts, 2010 This review provides a brief overview of the basic principles of epigenetic gene regulation and then focuses on recent development of epigenetic drugs for cancer treatment and prevention with an emphasis on the molecular mechanisms of action.
Yu Xiao-Dan, Guo Z. Sheng
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Editorial: Epigenetic drugs and therapeutic resistance for epithelial malignancies [PDF]
Frontiers in Pharmacology, 2023 Fangfang Tao +2 more
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Epigenetic Alterations in Cancer: The Therapeutic Potential of Epigenetic Drugs in Cancer Therapy
Drugs and Drug CandidatesTo date, numerous studies have emerged that indicate the possible role of epigenetic modulation in the development and progression of several diseases, including cancer. Epigenetic alterations participate in various steps of carcinogenesis.
Preeti Gupta
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Epigenetic drugs in cancer therapy [PDF]
Cancer and Metastasis ReviewsAmila Suraweera +2 more
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Targeting Epigenetic Changes Mediated by Members of the SMYD Family of Lysine Methyltransferases
Molecules, 2023 A comprehensive understanding of the mechanisms involved in epigenetic changes in gene expression is essential to the clinical management of diseases linked to the SMYD family of lysine methyltransferases.
Alyssa Padilla +5 more
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