Results 11 to 20 of about 1,306,054 (295)
Trials with ‘epigenetic’ drugs: An update [PDF]
Molecular Oncology, 2012 Epigenetic inactivation of pivotal genes involved in correct cell growth is a hallmark of human pathologies, in particular cancer. These epigenetic mechanisms, including crosstalk between DNA methylation, histone modifications and non‐coding RNAs, affect gene expression and are associated with disease progression.
NEBBIOSO, Angela +3 more
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Multitarget Drugs: an Epigenetic Epiphany [PDF]
ChemMedChem, 2016 AbstractEpigenetics refers to changes in a biological phenotype that are not due to an underlying change in genotype. In eukaryotes, epigenetics involves a set of chemical modifications of the DNA and the histone proteins in nucleosomes. These dynamic changes are carried out by enzymes and modulate protein–protein and protein–nucleic acid interactions ...
Ganesan, A., A. Ganesan
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Epigenetic drugs in Alzheimer’s disease
Biomolecular Concepts, 2013 Epigenetic processes, such as DNA methylation and histone acetylation, regulate the genome-environment interactions that may play important roles in a wide range of brain disorders, including Alzheimer’s disease (AD).
Cuadrado-Tejedor Mar +4 more
doaj +3 more sources
Epigenetic Modulation as a Therapeutic Prospect for Treatment of Autoimmune Rheumatic Diseases [PDF]
Mediators of Inflammation, 2016 Systemic inflammatory rheumatic diseases are considered as autoimmune diseases, meaning that the balance between recognition of pathogens and avoidance of self-attack is impaired and the immune system attacks and destroys its own healthy tissue ...
Marzena Ciechomska, Steven O’Reilly
doaj +2 more sources
Epigenetic targets in the diagnosis and treatment of prostate cancer [PDF]
International Brazilian Journal of Urology, 2007 Prostate cancer (PC) is one of leading cause of cancer related deaths in men. Various aspects of cancer epigenetics are rapidly evolving and the role of 2 major epigenetic changes including DNA methylation and histone modifications in prostate cancer is ...
Murugesan Manoharan +3 more
doaj +2 more sources
Epigenetics of psychoactive drugs [PDF]
Journal of Pharmacy and Pharmacology, 2012 Abstract Objectives Epigenetics refers to the heritable, but reversible regulation of various biological functions. Changes in DNA methylation and chromatin structure derived from histone modifications are involved in the brain development, pathogenesis and pharmacotherapy of brain disorders.
Nadka, Boyadjieva, Miroslava, Varadinova
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Cells, 2022 Anti-programmed death 1 (PD-1) is a revolutionary treatment for many cancers. The response to anti-PD-1 relies on several properties of tumor and immune cells, including the expression of PD-L1 and PD-1.
Delphine Sauvage +7 more
doaj +1 more source
Cold Spring Harbor Perspectives in Medicine, 2020 Substance use disorders (SUDs) are chronic brain diseases characterized by transitions from recreational to compulsive drug use and aberrant drug craving that persists for months to years after abstinence is achieved. The transition to compulsive drug use implies that plasticity is occurring, altering the physiology of the brain to precipitate addicted
Andrew F, Stewart +2 more
openaire +3 more sources
Pharmaco-Epigenetics and Epigenetic Drugs in Type 2 Diabetes: Can Epigenetics Predict Drug Efficiency? [PDF]
BiomedicinesType 2 Diabetes Mellitus (T2DM) is increasingly affecting individuals across various age groups due to inadequate insulin action and secretion. It has become the leading cause of mortality worldwide, with an estimated 9.3% of the global population currently affected.
Mkhize SS +3 more
europepmc +4 more sources
Drugs and epigenetic molecular functions. A pharmacological data scientometric analysis
, 2021 Interactions of drugs with the classical epigenetic mechanism of DNA methylation or histone modification are increasingly being elucidated mechanistically and used to develop novel classes of epigenetic therapeutics.
Dario Kringel +8 more
core +1 more source