Results 21 to 30 of about 1,306,054 (295)

Epigenetic mechanisms in drug addiction [PDF]

Trends in Molecular Medicine, 2008
Changes in gene expression in brain reward regions are thought to contribute to the pathogenesis and persistence of drug addiction. Recent studies have begun to focus on the molecular mechanisms by which drugs of abuse and related environmental stimuli, such as drug-associated cues or stress, converge on the genome to alter specific gene programs ...
William, Renthal, Eric J, Nestler
openaire   +2 more sources

Epigenetic Effects of Drugs of Abuse [PDF]

International Journal of Environmental Research and Public Health, 2018
Drug addiction affects a large extent of young people and disadvantaged populations. Drugs of abuse impede brain circuits or affect the functionality of brain circuits and interfere with bodily functions. Cannabinoids (Δ9-tetrahydrocannabinol) form key constituents of marijuana derived from the cannabis plant.
Thomas Heinbockel, Antonei B. Csoka
openaire   +2 more sources

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Ducasse, Miryam, Brown, Mark A., Ducasse Miryam, Brown Mark A   +3 more
core   +1 more source

Recent advances in epigenetic anticancer therapeutics and future perspectives

Frontiers in Genetics, 2023
Tumor development is frequently accompanied by abnormal expression of multiple genomic genes, which can be broadly viewed as decreased expression of tumor suppressor genes and upregulated expression of oncogenes.
Liwen Ren, Liwen Ren, Yihui Yang, Yihui Yang, Wan Li, Wan Li, Hong Yang, Hong Yang, Yizhi Zhang, Yizhi Zhang, Binbin Ge, Binbin Ge, Sen Zhang, Sen Zhang, Guanhua Du, Guanhua Du, Jinhua Wang, Jinhua Wang   +17 more
doaj   +1 more source

Epigenetics in diagnosis, prognostic assessment and treatment of cancer:An update [PDF]

, 2014
Cancer cells contain multiple genetic and epigenetic changes. The relative specificity of many epigenetic changes for neoplastic cells has allowed the identification of diagnostic, prognostic and predictive biomarkers for a number of solid tumors and ...
Crook, Tim, Briasoulis, Evangelos, Sim, Van Ren, Hatzimichael, Eleftheria, Lagos, Konstantinos   +4 more
core   +1 more source

Potential directions for drug development for osteoarthritis [PDF]

, 2008
Background: osteoarthritis (OA) is a frustrating disease for both patient and physician because neither cause nor cure is known and there are currently no disease-modifying drugs.
Roach, Helmtrud I.
core   +1 more source

Epigenetic polypharmacology: from combination therapy to multitargeted drugs [PDF]

, 2016
The modern drug discovery process has largely focused its attention in the so-called magic bullets, single chemical entities that exhibit high selectivity and potency for a particular target.
Ganesan, A., A. Ganesan, de Lera, Angel R., Angel R. de Lera, Rodríguez de Lera, Ángel, Ganesan, A   +5 more
core   +1 more source

Epigenetic regulation of adaptive responses of forest tree species to the environment [PDF]

, 2013
Epigenetic variation is likely to contribute to the phenotypic plasticity and adaptative capacity of plant species, and may be especially important for long-lived organisms with complex life cycles, including forest trees.
Maury, Stéphane, Bräutigam, Katharina, Antje Rohde, M. Ángeles Guevara, Dolores Abarca, Rohde, Antje, Fluch, S., Fluch, Silvia, Fraga, Mario F., Clément Lafon‐Placette, Johnsen, Oystein, Lafon-Placette, Clément, Jose, Gutiérrez-Marcos, Angeles Guevara, M., Campbell, Malcolm M., Fossdal, Carl G., Steven H. Strauss, Bräutigam, K., Fossdal, C. G., Abarca, Dolores, Mirouze, M., Katharina Bräutigam, Malcolm M. Campbell, Lafon-Placette, C., Vining, Kelly J., Gutierrez Marcos, Jose, Campbell, M. M., Rohde, A., Fernandez Fraga, Mario, José Gutiérrez Marcos, Marcos, J. G., Marie Mirouze, Silvia Fluch, Fraga, Mario Fernández, Cervera, María-Teresa, Díaz-Sala, Carmen, María‐Teresa Cervera, Guevara, M. Ángeles, Cervera, María Teresa, Johnsen, Øystein, Strauss, Steven H., Mario Fernández Fraga, Braeutigam, Katharina, Guevara, M Ángeles, Øystein Johnsen, Stéphane Maury, Mirouze, Marie, Kelly J. Vining, Johnsen, O., Vining, K. J., Carl G. Fossdal, Carmen Díaz‐Sala   +51 more
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Epigenetic-based therapies for Friedreich ataxia [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Friedreich ataxia (FRDA) is a lethal autosomal recessive neurodegenerative disorder caused primarily by a homozygous GAA repeat expansion mutation within the first intron
Madhavi Sandi, Al-Mahdawi, S, Sahar eAl-Mahdawi, Chiranjeevi eSandi, Madhavi eSandi, Sara eAnjomani-Virmouni, Sandi, C, Virmouni, SA, Sandi, M, Pook, MA, Mark Adrian Pook, Sahar Al-Mahdawi, Chiranjeevi Sandi, Sara Anjomani Virmouni, Mark A. Pook   +14 more
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NF-κB in innate neuroprotection and age-related neurodegenerative diseases

Frontiers in Neurology, 2015
NF-κB factors are cardinal transcriptional regulators of inflammation and apoptosis, involved in the brain programming of systemic aging and in brain damage. The composition of NF-κB active dimers and epigenetic mechanisms modulating histone acetylation,
Annamaria eLanzillotta, Vanessa ePorrini, Vanessa ePorrini, Arianna eBellucci, Marina eBenarese, Caterina eBranca, Edoardo eParrella, Pier Franco Spano, Pier Franco Spano, Marina ePizzi, Marina ePizzi   +10 more
doaj   +1 more source