Results 41 to 50 of about 1,306,054 (295)

Epigenetic mechanisms of drug addiction [PDF]

Current Opinion in Neurobiology, 2013
Epigenetic regulation can mediate long-lasting changes in gene expression, which makes it an attractive mechanism for the stable behavioral abnormalities that characterize drug addiction. Recent research has unveiled numerous types of epigenetic modifications within the brain's reward circuitry in animal models of drug addiction.
Jian, Feng, Eric J, Nestler
openaire   +2 more sources

Epigenetic Regulation in Melanoma: Facts and Hopes

Cells, 2021
Cutaneous melanoma is a lethal disease, even when diagnosed in advanced stages. Although recent progress in biology and treatment has dramatically improved survival rates, new therapeutic approaches are still needed.
Emilio Francesco Giunta, Gianluca Arrichiello, Marcello Curvietto, Annalisa Pappalardo, Davide Bosso, Mario Rosanova, Anna Diana, Pasqualina Giordano, Angelica Petrillo, Piera Federico, Teresa Fabozzi, Sara Parola, Vittorio Riccio, Brigitta Mucci, Vito Vanella, Lucia Festino, Bruno Daniele, Paolo Antonio Ascierto, Margaret Ottaviano, On Behalf of SCITO YOUTH   +19 more
doaj   +1 more source

Epigenetic Priming in Drug Addiction [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2018
Drug addiction is a chronic relapsing brain disorder that is characterized by compulsive drug seeking and continued use despite negative outcomes. Current pharmacological therapies target neuronal receptors or transporters upon which drugs of abuse act initially, yet these treatments remain ineffective for most individuals and do not prevent disease ...
Mews, Philipp, Walker, Deena M., Nestler, Eric J.   +2 more
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Epigenetic Mechanisms in Drug Relapse

Biological Psychiatry, 2021
A growing body of evidence from the past 15 years implicates epigenetic mechanisms in the behavioral effects of addictive drugs. The main focus of these studies has been epigenetic mechanisms of psychomotor sensitization and drug reinforcement, as assessed by the conditioned place preference and drug self-administration procedures.
Craig T. Werner, Rachel D. Altshuler, Yavin Shaham, Xuan Li   +3 more
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The timeline of epigenetic drug discovery:From reality to dreams [PDF]

, 2019
The flexibility of the epigenome has generated an enticing argument to explore its reversion through pharmacological treatments as a strategy to ameliorate disease phenotypes.
Arimondo, Paola, Ganesan, A., Jeronimo, Carmen, Ganesan, A, Rots, Marianne G., Rots, Marianne, Arimondo, Paola B., Berdasco, Mariá   +7 more
core   +1 more source

Collateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer

Frontiers in Cell and Developmental Biology, 2021
Disrupted DNA damage signaling greatly threatens cell integrity and plays significant roles in cancer. With recent advances in understanding the human genome and gene regulation in the context of DNA damage, chromatin biology, specifically biology of ...
Lishu He, Lishu He, Lishu He, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk   +6 more
doaj   +1 more source

Current and upcoming approaches to exploit the reversibility of epigenetic mutations in breast cancer [PDF]

, 2014
DNA methylation and histone modifications are important epigenetic modifications associated with gene (dys) regulation. The epigenetic modifications are balanced by epigenetic enzymes, so-called writers and erasers, such as DNA (de)methylases and histone
Geke Hospers, van Kruchten, Michel, Martinet, Nadine, Michel van Kruchten, Nadine Martinet, Rots, Marianne G., Marianne G Rots, Falahi, Fahimeh, Fahimeh Falahi, Hospers, Geesiena   +9 more
core   +3 more sources

Epigenetic regulation during fetal femur development: DNA methylation matters [PDF]

, 2013
Epigenetic modifications are heritable changes in gene expression without changes in DNA sequence. DNA methylation has been implicated in the control of several cellular processes including differentiation, gene regulation, development, genomic ...
Oreffo Richard O. C., Oreffo, Richard O. C., Antonio Gonzalez, González Martínez-Pedrayo, Antonio, Richard O C Oreffo, de Andrés María C., Roach Helmtrud I., Wilson, David I., Kingham, Emmajayne, Kingham Emmajayne, Helmtrud I Roach, Oreffo, Richard O C, Emmajayne Kingham, Kei Imagawa, María C de Andrés, Roach, Helmtrud I, Wilson David I., de Andrés, María C., Imagawa, Kei, Roach, Helmtrud I., De Andrés González, Mª Carmen, Imagawa Kei, Wilson, David I, Neves, Nuno M., David I Wilson, Gonzalez, Antonio, Gonzalez Antonio   +26 more
core   +1 more source

Epigenetic Drugs for Multiple Sclerosis. [PDF]

Curr Neuropharmacol, 2016
There is increasing evidence that abnormalities in epigenetic mechanisms of gene expression contribute to the development of multiple sclerosis (MS). Advances in epigenetics have given rise to a new class of drugs, epigenetic drugs. Although many classes of epigenetic drugs are being investigated, at present most attention is being paid to two classes ...
Peedicayil J.
europepmc   +4 more sources

Epigenetic mechanisms of drug addiction [PDF]

Neuropharmacology, 2014
Drug addiction involves potentially life-long behavioral abnormalities that are caused in vulnerable individuals by repeated exposure to a drug of abuse. The persistence of these behavioral changes suggests that long-lasting changes in gene expression, within particular regions of the brain, may contribute importantly to the addiction phenotype.
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