Results 31 to 40 of about 1,306,054 (295)
Understanding the Mechanisms by Which Epigenetic Modifiers Avert Therapy Resistance in Cancer
Frontiers in Oncology, 2020 The development of resistance to anti-cancer therapeutics remains one of the core issues preventing the improvement of survival rates in cancer. Therapy resistance can arise in a multitude of ways, including the accumulation of epigenetic alterations in ...
Anthony Quagliano +5 more
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Antimicrobial resistance and mechanisms of epigenetic regulation
Frontiers in Cellular and Infection Microbiology, 2023 The rampant use of antibiotics in animal husbandry, farming and clinical disease treatment has led to a significant issue with pathogen resistance worldwide over the past decades. The classical mechanisms of resistance typically investigate antimicrobial
Xinrui Wang +5 more
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Molecules, 2019 Background: KDM5 enzymes are H3K4 specific histone demethylases involved in transcriptional regulation and DNA repair. These proteins are overexpressed in different kinds of cancer, including breast, prostate and bladder carcinomas, with positive effects
Simone Pippa +11 more
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Epigenetic management of major psychosis [PDF]
, 2011 Epigenetic mechanisms are thought to play a major role in the pathogenesis of the major psychoses (schizophrenia and bipolar disorder), and they may be the link between the environment and the genome in the pathogenesis of these disorders.
Jacob Peedicayil
core +2 more sources
Epigenetic therapy in gastrointestinal cancer: the right combination
Therapeutic Advances in Gastroenterology, 2016 Epigenetics is a relatively recent field of molecular biology that has arisen over the past 25 years. Cancer is now understood to be a disease of widespread epigenetic dysregulation that interacts extensively with underlying genetic mutations.
Eihab Abdelfatah +3 more
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Research Progress of Epigenetics in Pathogenesis and Treatment of Malignant Tumors
Chinese Journal of Lung Cancer, 2020 Epigenetic modification is closely related to the occurrence and development of tumors. It mainly regulates gene function and expression level through DNA methylation, histone modification, regulation of non-coding RNA and chromatin structure ...
Pan WANG +10 more
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Advancements in the delivery of epigenetic drugs. [PDF]
Expert Opin Drug Deliv, 2015 Advancements in epigenetic treatments are not only coming from new drugs, but also from modifications or encapsulation of the existing drugs into different formulations leading to greater stability and enhanced delivery to the target site. The epigenome is highly regulated and complex; therefore, it is important that off-target effects of epigenetic ...
Cramer SA, Adjei IM, Labhasetwar V.
europepmc +4 more sources
Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences [PDF]
, 2012 Genetic-epidemiological studies on monozygotic (MZ) twins have been used for decades to tease out the relative contributions of genes and the environment to a trait.
Morahan, JM +11 more
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From Bench to Bedside: Targeting Epigenetics for Cancer Therapy
Cancer Biology & Medicine, 2011 The initiation and progression of cancer not only involves genetic abnormalities, but also epigenetic alterations, such as DNA methylation and histone modifications.
Jin-xu Fang, Gui-deng Li
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Direct but no transgenerational effects of decitabine and vorinostat on male fertility. [PDF]
PLoS ONE, 2015 Establishment and maintenance of the correct epigenetic code is essential for a plethora of physiological pathways and disturbed epigenetic patterns can provoke severe consequences, e.g. tumour formation.
Ruth Kläver +10 more
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