Results 51 to 60 of about 1,306,054 (295)

Epigenetics in pharmacogenes encoding metabolizing enzymes of second-generation antipsychotics used in schizophrenia and its clinical implications

Frontiers in Pharmacology
Schizophrenia is a neuropsychiatric disorder caused by neurochemical alterations, non-genetic, genetic, epigenetic and environmental factors. Pharmacoepigenetics studies the relationship between epigenetic variability and response to drugs. The objective
Angel T. Alvarado, Amparo Iris Zavaleta, César Li-Amenero, María R. Bendezú, Jorge A. Garcia, Haydee Chávez, Juan J. Palomino-Jhong, Felipe Surco-Laos, Doris Laos-Anchante, Elizabeth J. Melgar-Merino, Mario Bolarte-Arteaga, Nesquen Tasayco-Yataco, Ricardo Pariona-Llanos   +12 more
doaj   +1 more source

Role of epigenetics-microRNA axis in drug resistance of multiple myeloma

Journal of Hematology & Oncology, 2017
Despite administration of novel therapies, multiple myeloma (MM) remains incurable with resistance to drugs leading to relapse in most patients. Thus, it is critical to understand the detailed mechanisms underlying the drug resistance of MM and develop ...
Nasrin Rastgoo, Jahangir Abdi, Jian Hou, Hong Chang   +3 more
doaj   +1 more source

Epigenetic Immune Remodeling of Mesothelioma Cells: A New Strategy to Improve the Efficacy of Immunotherapy

Epigenomes, 2021
Malignant pleural mesothelioma (MPM) is an aggressive malignancy with a severe prognosis, and with a long-standing need for more effective therapeutic approaches.
Maria Fortunata Lofiego, Sara Cannito, Carolina Fazio, Francesca Piazzini, Ornella Cutaia, Laura Solmonese, Francesco Marzani, Carla Chiarucci, Anna Maria Di Giacomo, Luana Calabrò, Sandra Coral, Michele Maio, Alessia Covre, on behalf of the EPigenetic Immune-Oncology Consortium Airc (EPICA) Investigators   +13 more
doaj   +1 more source

Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]

, 2006
Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
Glasspool, R.M., Teodoridis, JM, Glasspool, RM, Teodoridis, J.M., Brown, R, R M Glasspool, Brown, R., J M Teodoridis, R Brown   +8 more
core   +1 more source

Epigenetic regulation of angiogenesis and its therapeutics

Genomics & Informatics
Angiogenesis, the formation of new blood vessels from preexisting ones, is essential for normal development, wound healing, and tissue repair. However, dysregulated angiogenesis is implicated in various pathological conditions, including cancer, diabetic
Dong Kyu Choi
doaj   +1 more source

Epigenetics in cancer therapy and nanomedicine

Clinical Epigenetics, 2019
The emergence of nanotechnology applied to medicine has revolutionized the treatment of human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs have evolved in terms of their specificity and efficiency, especially ...
Annalisa Roberti, Adolfo F. Valdes, Ramón Torrecillas, Mario F. Fraga, Agustin F. Fernandez   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Synergistic association of resveratrol and histone deacetylase inhibitors as treatment in amyotrophic lateral sclerosis

Frontiers in Pharmacology, 2022
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with motor neuron degeneration, progressive paralysis and finally death. Despite the research efforts, currently there is no cure for ALS.
Edoardo Parrella, Vanessa Porrini, Ilaria Scambi, Michele M. Gennari, Cristina Gussago, Oluwamolakun Bankole, Marina Benarese, Raffaella Mariotti, Marina Pizzi   +8 more
doaj   +1 more source

Role of histone methylation in paternal transmission of epigenetic information [PDF]

, 2010
During the development of multi-cellular organisms, one genome gives rise to multiple differentiated cell types. This is achieved by sequence specific transcription factors and different epigenetic mechanisms, which collaborate in reading the genetic ...
Brykczynska, Urszula
core   +1 more source