Results 241 to 250 of about 2,264,000 (323)

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Polyamine Induction of Secondary Metabolite Biosynthetic Genes in Fungi Is Mediated by Global Regulator LaeA and α-NAC Transcriptional Coactivator: Connection to Epigenetic Modification of Histones. [PDF]

Molecules
Martín JF.
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Sex-specific role of epigenetic modification of a leptin upstream enhancer in adipose tissue. [PDF]

Clin Epigenetics
Müller L, Oelkrug R, Mittag J, Hoffmann A, Ghosh A, Noé F, Wolfrum C, Guiu Jurado E, Klöting N, Dietrich A, Blüher M, Kovacs P, Krause K, Keller M.   +13 more
europepmc   +1 more source

Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain

Proceedings of the National Academy of Sciences of the United States of America, 2015
M. Puglia, Travis S. Lillard, James P. Morris, J. Connelly   +3 more
semanticscholar   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Small molecules and heat treatments reverse vernalization via epigenetic modification in Arabidopsis. [PDF]

Commun Biol
Otsuka N, Yamaguchi R, Sawa H, Kadofusa N, Kato N, Nomura Y, Yamaguchi N, Nagano AJ, Sato A, Shirakawa M, Ito T.   +10 more
europepmc   +1 more source

Epigenetic modifications during exercise

Mapping on the human genome and genome of other organisms revealed not only the DNA organization principles, but also showed the regulation complexity of the structural and metabolic genes expression. It turned out that external influences such as nutrition, stress, physical activity and other external stimuli change genes expression and control it ...
Goldberg, ND, Astratenkova, IV, Akhmetov, I, Rogozkin, VA   +3 more
openaire  

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification. [PDF]

Signal Transduct Target Ther
Mao Z, Liu W, Zou R, Sun L, Huang S, Wu L, Chen L, Wu J, Lu S, Song Z, Li X, Huang Y, Rao Y, Huang YY, Li B, Hu Z, Li J.   +16 more
europepmc   +1 more source