Results 11 to 20 of about 11,016 (219)
Sirtuins in Epigenetic Regulation [PDF]
Chemical Reviews, 2015 1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information regulator 2 (SIR2) protein, one of four proteins (SIR1–4) required for silencing the mating-type information loci in yeast.1 SIR2–4, but not SIR1, are also required for gene silencing at telomeres.2 SIR2 also mediates gene silencing at the rDNA (rDNA) loci ...
Jing, Hui, Lin, Hening
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Epigenetic regulation of hematopoiesis [PDF]
International Journal of Hematology, 2012 Epigenetic regulation is required not only for development, but also for tissue homeostasis, which is maintained via the self-renewal and differentiation of somatic stem cells. Accumulating evidence suggests that epigenetic regulators play critical roles in the maintenance of both self-renewing hematopoietic stem cells and leukemic stem cells.
Goro, Sashida, Atsushi, Iwama
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Cells, 2019 Human rDNA clusters form numerous contacts with different chromosomal regions as evidenced by chromosome conformation capture data. Heterochromatization of rDNA genes leads to heterochromatization in different chromosomal regions coupled with the ...
Nickolai A. Tchurikov +6 more
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Epigenetic Regulation in Plants [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 The study of epigenetics in plants has a long and rich history, from initial descriptions of non-Mendelian gene behaviors to seminal discoveries of chromatin-modifying proteins and RNAs that mediate gene silencing in most eukaryotes, including humans. Genetic screens in the model plant Arabidopsis have been particularly rewarding, identifying more than
Craig S, Pikaard +1 more
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BMC Genomics, 2019 Background Polycomb group (PcG) proteins play important roles in animal and plant development and stress response. Polycomb repressive complex 1 (PRC1) and PRC2 are the key epigenetic regulators of gene expression, and are involved in almost all ...
Yong Huang +6 more
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Epigenetic Regulation of Adipokines [PDF]
International Journal of Molecular Sciences, 2017 Adipose tissue expansion in obesity leads to changes in the expression of adipokines, adipocyte-specific hormones that can regulate whole body energy metabolism. Epigenetic regulation of gene expression is a mechanism by which cells can alter gene expression through the modifications of DNA and histones.
Pham, Tho X., Lee, Ji-Young
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Molecular Therapy: Nucleic Acids, 2017 RNAi has been suggested for use in gene therapy of HIV/AIDS, but the main problem is that HIV-1 is highly variable and could escape attack from the small interfering RNAs (siRNAs) due to even single nucleotide substitutions in the potential targets.
Olga V. Kretova +8 more
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Plants, 2023 Plant trichomes formed by specialized epidermal cells play a role in protecting plants from biotic and abiotic stresses and can also influence the economic and ornamental value of plant products.
Jing Zeng +5 more
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Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions
Nature Communications, 2021 Here, Yang et al. apply different RNA sequencing approaches to characterize the secondary structure of SARS-CoV-2 viral RNAs, report on long-range interactions along the viral genome, and uncover the virus-host RNA interactome in cells.
Siwy Ling Yang +15 more
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