Results 21 to 30 of about 11,016 (219)

Epigenetic regulation of cholesterol homeostasis [PDF]

Frontiers in Genetics, 2014
Although best known as a risk factor for cardiovascular disease, cholesterol is a vital component of all mammalian cells. In addition to key structural roles, cholesterol is a vital biochemical precursor for numerous biologically important compounds including oxysterols and bile acids, as well as acting as an activator of critical morphogenic systems ...
Steve eMeaney, Steve eMeaney
openaire   +4 more sources

Clinical analysis of 11 cases of nocardiosis

Open Medicine, 2021
Nocardiosis is a rare, life-threatening, opportunistic, and suppurative infection. Its clinical manifestation lacks specificity, which makes early diagnosis difficult.
Li Yiqing, Tang Ting, Xiao Jie, Wang Jieyu, Li Boqi, Ma Liping, Xie Shuangfeng, Nie Danian   +7 more
doaj   +1 more source

Epigenetic Regulation in the Control of Flowering [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2004
The timing of flowering has significant consequencesfor the reproductive success of plants. Plants need togauge when both environmental and endogenous cues areoptimal before undergoing the switch from vegetative toreproductive development. To achieve this, a complexregulatory network has evolved consisting of multiplepathways that quantitatively ...
Mylne, J. S., Greb, T., Lister, C., Dean, C.   +3 more
openaire   +4 more sources

Asymmetric division of stem cells and its cancer relevance

Cell Regeneration
Asymmetric division is a fundamental process for generating cell diversity and maintaining the stem cell population. During asymmetric division, proteins, organelles, and even RNA are distributed unequally between the two daughter cells, determining ...
Shanshan Chao, Huiwen Yan, Pengcheng Bu
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

scIVNL-seq resolves in vivo single-cell RNA dynamics of immune cells during Salmonella infection

Nature Communications
The immune response against pathogens involves multiple cell state transitions and complex gene expression changes. Here, we establish a single-cell in vivo new RNA labeling sequencing method (scIVNL-seq) and apply it to survey time-resolved RNA dynamics
Zhen Xiong, Runyuan Wu, Yuanxin Wang, Yuwei Xu, Cunzhen Li, Deyuan Kong, Ziqi Xiao, Peikang Zhang, Zhonglong Wang, Peng Zhang, Ying Du, Hui Guo, Pingping Zhu, Shunmin He, Zusen Fan   +14 more
doaj   +1 more source

pHYPER, a shRNA vector for high-efficiency RNA interference in embryonic stem cells

BioTechniques, 2007
RNA interference (RNAi) is a powerful method to generate loss-of-function phenotypes. Plasmid vectors with RNA polymerase III promoters have been developed to express short hairpin RNAs (shRNAs) in mammalian cells.
Soizik Berlivet, Virginie Guiraud, Martin Houlard, Matthieu Gérard   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Engineering a CRISPR-associated IscB system for developing miniature genome-editing tools in human cells and mouse embryos

Nature Communications
IscB, as the putative ancestor of Cas9, possesses a compact size, making it suitable for in vivo delivery. OgeuIscB is the first IscB protein known to function in eukaryotic cells but requires a complex TAM (NWRRNA).
Fei Zhang, Yuxin Peng, Dongdong Fan, Guoxu Song, Xing Gao, Yong Tian   +5 more
doaj   +1 more source

Isolation and Identification of an α-Galactosidase-Producing Lactosphaera pasteurii Strain and Its Enzymatic Expression Analysis

Molecules, 2022
α-Galactosidase (EC 3.2.1.22) refers to a group of enzymes that hydrolyze oligosaccharides containing α-galactoside-banded glycosides, such as stachyose, raffinose, and verbascose.
Yan Zhao, Jinghui Zhou, Shan Dai, Xiaozhu Liu, Xuewen Zhang   +4 more
doaj   +1 more source