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Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Signal Transduction and Targeted Therapy, 2023 Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout, hyperthyroidism, hypothyroidism and others.
Yan-Lin Wu +9 more
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Indian Journal of Medical and Paediatric Oncology, 2020 Historically, cancer is known to be a genetic disease. It is now realized that it involves epigenetic abnormalities along with genetic alterations. Epigenetics is an extra layer of instruction that lies upon DNA and controls how the genes are read and ...
Ravi Jaiswal, Esha Jafa
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The Crosstalk of Epigenetics and Metabolism in Herpesvirus Infection
Viruses, 2020 Epigenetics is a versatile player in manipulating viral infection and a potential therapeutic target for the treatment of viral-induced diseases. Both epigenetics and metabolism are crucial in establishing a highly specific transcriptional network, which
Yonggang Pei, Erle S. Robertson
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Epigenetics and Cancer: A Comprehensive Review
Asian Pacific Journal of Cancer Biology, 2023 Cancer is a disease with extraordinary clinical significance, with much of medical research being devoted to it. Innumerable factors are relevant in fully understanding cancer but the epigenetic aspect stands out.
Ayush Pathak +2 more
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Nature Communications, 2020 The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is regulated remains poorly understood. Here the authors find that there is a shared subset of CTCF-bound sites resistant to protein depletion in ...
Amanda Khoury +13 more
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Epigenetics for the 21st-Century Biology Student
Journal of Microbiology & Biology Education, 2019 Epigenetics, a rapidly emerging biological science, investigates changes in gene expression without any change to the primary DNA sequence. Epigenetics plays an important role in diverse areas, including nutritional sciences, psychology, and ...
Jonghoon Kang +3 more
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Lowly methylated region analysis identifies EBF1 as a potential epigenetic modifier in breast cancer
Epigenetics, 2017 Breast cancer (BC) encompasses heterogeneous pathologies with different subtypes exhibiting distinct molecular changes, including those related to DNA methylation.
Nora Fernandez-Jimenez +9 more
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Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups
Epigenetics & Chromatin, 2019 Background ATP-dependent chromatin remodelling complexes are responsible for establishing and maintaining the positions of nucleosomes. Chromatin remodellers are targeted to chromatin by transcription factors and non-coding RNA to remodel the chromatin ...
Katherine A. Giles +9 more
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Epigenetics Regulates Antitumor Immunity in Melanoma
Frontiers in Immunology, 2022 Melanoma is the most malignant skin cancer, which originates from epidermal melanocytes, with increasing worldwide incidence. The escape of immune surveillance is a hallmark of the tumor, which is manifested by the imbalance between the enhanced immune ...
Yuhan Chen +6 more
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Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA
Epigenetics & Chromatin, 2017 Background The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping the mammalian DNA methylation ...
Ksenia Skvortsova +6 more
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