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Evidence of Epigenetic Oncogenesis: A Turning Point in Cancer Research. [PDF]

Bioessays
In cancer research, the term epigenetics was used in the 1970s in its modern sense encompassing non-genetic events modifying the chromatin state, mainly to oppose the emerging oncogene paradigm. However, starting from the establishment of this prominent concept, the importance of these epigenetic phenomena in cancer rarely led to questioning the causal
Capp JP, Aliaga B, Pancaldi V.
europepmc   +2 more sources

Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study

Signal Transduction and Targeted Therapy, 2023
Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout, hyperthyroidism, hypothyroidism and others.
Yan-Lin Wu, Zheng-Jun Lin, Chang-Chun Li, Xiao Lin, Su-Kang Shan, Bei Guo, Ming-Hui Zheng, Fuxingzi Li, Ling-Qing Yuan, Zhi-hong Li   +9 more
doaj   +1 more source

How Epigenetics Contributes to the Understanding of Human Development

ESPOCH Congresses, 2021
Introduction: Epigenetics, which studies the phenotypic expression of certain characteristics in relation to the interaction with the environment, specifically of the primary DNA (deoxyribonucleic acid) sequence and that does not modulate the genetic ...
Iván Enrique Naranjo Logroño, Anthony Alfonso Naranjo Coronel, Alison Tamara Ruiz Chico, Leslie Gricel Cuzco Macías   +3 more
doaj   +1 more source

The Crosstalk of Epigenetics and Metabolism in Herpesvirus Infection

Viruses, 2020
Epigenetics is a versatile player in manipulating viral infection and a potential therapeutic target for the treatment of viral-induced diseases. Both epigenetics and metabolism are crucial in establishing a highly specific transcriptional network, which
Yonggang Pei, Erle S. Robertson
doaj   +1 more source

Epigenetics and Cancer: A Comprehensive Review

Asian Pacific Journal of Cancer Biology, 2023
Cancer is a disease with extraordinary clinical significance, with much of medical research being devoted to it. Innumerable factors are relevant in fully understanding cancer but the epigenetic aspect stands out.
Ayush Pathak, Sarthak Tomar, Sujata Pathak   +2 more
doaj   +1 more source

EPIGENETICS

Revista de la Sociedad Argentina de Diabetes, 2020
It is now accepted that the product of pregnancy in mothers who have been exposed to malnutrition, obesity or gestational diabetes (GD) has an increased risk of developing chronic diseases throughout their lives.
Cristina Faingold
doaj   +3 more sources

Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains

Nature Communications, 2020
The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is regulated remains poorly understood. Here the authors find that there is a shared subset of CTCF-bound sites resistant to protein depletion in ...
Amanda Khoury, Joanna Achinger-Kawecka, Saul A. Bert, Grady C. Smith, Hugh J. French, Phuc-Loi Luu, Timothy J. Peters, Qian Du, Aled J. Parry, Fatima Valdes-Mora, Phillippa C. Taberlay, Clare Stirzaker, Aaron L. Statham, Susan J. Clark   +13 more
doaj   +1 more source

Epigenetics for the 21st-Century Biology Student

Journal of Microbiology & Biology Education, 2019
Epigenetics, a rapidly emerging biological science, investigates changes in gene expression without any change to the primary DNA sequence. Epigenetics plays an important role in diverse areas, including nutritional sciences, psychology, and ...
Jonghoon Kang, Jenna R. Daines, Abbey N. Warren, Matthew L. Cowan   +3 more
doaj   +1 more source

Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer

Nature Communications, 2020
Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound enhancer-promoter interactions is a key mechanism underlying endocrine resistance.
Joanna Achinger-Kawecka, Fatima Valdes-Mora, Phuc-Loi Luu, Katherine A. Giles, C. Elizabeth Caldon, Wenjia Qu, Shalima Nair, Sebastian Soto, Warwick J. Locke, Nicole S. Yeo-Teh, Cathryn M. Gould, Qian Du, Grady C. Smith, Irene R. Ramos, Kristine F. Fernandez, Dave S. Hoon, Julia M. W. Gee, Clare Stirzaker, Susan J. Clark   +18 more
doaj   +1 more source

Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups

Epigenetics & Chromatin, 2019
Background ATP-dependent chromatin remodelling complexes are responsible for establishing and maintaining the positions of nucleosomes. Chromatin remodellers are targeted to chromatin by transcription factors and non-coding RNA to remodel the chromatin ...
Katherine A. Giles, Cathryn M. Gould, Qian Du, Ksenia Skvortsova, Jenny Z. Song, Madhavi P. Maddugoda, Joanna Achinger-Kawecka, Clare Stirzaker, Susan J. Clark, Phillippa C. Taberlay   +9 more
doaj   +1 more source