Results 11 to 20 of about 458,162 (417)
Epigenetics and depression [PDF]
Dialogues in Clinical Neuroscience, 2019 The risk for major depression is both genetically and environmentally determined. It has been proposed that epigenetic mechanisms could mediate the lasting increases in depression risk following exposure to adverse life events and provide a mechanistic framework within which genetic and environmental factors can be integrated.
Signe Penner-Goeke, Elisabeth B. Binder
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New England Journal of Medicine, 2008 Classic genetics alone cannot explain the diversity of phenotypes within a population. Nor does classic genetics explain how, despite their identical DNA sequences, monozygotic twins or cloned animals can have different phenotypes and different susceptibilities to a disease.
M. Esteller
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Cancer epigenetics in clinical practice
Ca, 2022 Cancer development is driven by the accumulation of alterations affecting the structure and function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic alterations contribute to the acquisition of hallmark tumor capabilities by ...
V. Davalos, M. Esteller
semanticscholar +1 more source
NeuroToxicology, 2023 Methylmercury (MeHg) is neurotoxic at high levels and particularly affects the developing brain. One proposed mechanism of MeHg neurotoxicity is alteration of the epigenetic programming. In this review, we summarise the experimental and epidemiological literature on MeHg-associated epigenetic changes.Experimental and epidemiological studies have ...
Cediel-Ulloa, Andrea +3 more
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The modern versus extended evolutionary synthesis : sketch of an intra-genomic gene's eye view for the evolutionary-genetic underpinning of epigenetic and developmental evolution [PDF]
, 2018 Studying the phenotypic evolution of organisms in terms of populations of genes and genotypes, the Modern Synthesis (MS) conceptualizes biological evolution in terms of 'inter-organismal' interactions among genes sitting in the different individual ...
Blancke, Stefaan +2 more
core +6 more sources
The Crosstalk of Epigenetics and Metabolism in Herpesvirus Infection
Viruses, 2020 Epigenetics is a versatile player in manipulating viral infection and a potential therapeutic target for the treatment of viral-induced diseases. Both epigenetics and metabolism are crucial in establishing a highly specific transcriptional network, which
Yonggang Pei, Erle S. Robertson
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Epigenetics and Cancer: A Comprehensive Review
Asian Pacific Journal of Cancer Biology, 2023 Cancer is a disease with extraordinary clinical significance, with much of medical research being devoted to it. Innumerable factors are relevant in fully understanding cancer but the epigenetic aspect stands out.
Ayush Pathak +2 more
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Ethical implications of epigenetics in the era of personalized medicine
Clinical Epigenetics, 2022 Given the increasing research activity on epigenetics to monitor human diseases and its connection with lifestyle and environmental expositions, the field of epigenetics has attracted a great deal of interest also at the ethical and societal level.
J. Santaló, M. Berdasco
semanticscholar +1 more source
Genetics and Epigenetics in Asthma
International Journal of Molecular Sciences, 2021 Asthma is one of the most common respiratory disease that affects both children and adults worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly understood. As technology in genome sequencing progressed, scientific efforts were
P. Ntontsi +4 more
semanticscholar +1 more source
Non-mammalian model organisms in epigenetic research : an overview [PDF]
, 2020 Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik +3 more
core +2 more sources