Results 11 to 20 of about 175,170 (271)
Lowly methylated region analysis identifies EBF1 as a potential epigenetic modifier in breast cancer
Epigenetics, 2017 Breast cancer (BC) encompasses heterogeneous pathologies with different subtypes exhibiting distinct molecular changes, including those related to DNA methylation.
Nora Fernandez-Jimenez +9 more
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Epigenetics Regulates Antitumor Immunity in Melanoma
Frontiers in Immunology, 2022 Melanoma is the most malignant skin cancer, which originates from epidermal melanocytes, with increasing worldwide incidence. The escape of immune surveillance is a hallmark of the tumor, which is manifested by the imbalance between the enhanced immune ...
Yuhan Chen +6 more
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Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA
Epigenetics & Chromatin, 2017 Background The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping the mammalian DNA methylation ...
Ksenia Skvortsova +6 more
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Nature Communications, 2019 The connection between DNA replication timing and changes that occur to the epigenome in cancer are still poorly understood. Here, the authors perform Repli-Seq and integrated epigenome analyses and find that genomic regions that undergo long-range ...
Qian Du +13 more
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Strategies for targeting chondrosarcomas in vivo and molecular dissection of oncogenic events in chondrosarcomas: is epigenetics the culprit? [PDF]
arXiv, 2023 It is obvious that both epigenetic and non-epigenetic actors contribute to tumorigenesis in chondrosarcomas and more generally in other cancers. Thus, the main altered pathways in chondrosarcomas are now well established and include both epigenetic and non-epigenetic pathways such as the PI3K-AKT signaling, EGFR overexpression, SPARC overexpression, c ...
arxiv
Epigenetic Transitions and Knotted Solitons in Stretched Chromatin [PDF]
Scientific Reports, 7, 14642 (2017), 2017 The spreading and regulation of epigenetic marks on chromosomes is crucial to establish and maintain cellular identity. Nonetheless, the dynamical mechanism leading to the establishment and maintenance of a given, cell-line specific, epigenetic pattern is still poorly understood.
arxiv +1 more source
Teaching & Learning Inquiry: The ISSOTL Journal, 2020 Mental health researchers emphasize the importance of practitioner understanding of biology-environment interplay. Accordingly, our goal of the study described in this article was to understand students’ preconceptions and misconceptions about biological
Kate E. Snyder +3 more
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Maternal SMCHD1 regulates Hox gene expression and patterning in the mouse embryo
Nature Communications, 2022 Parents transmit both genetic and epigenetic information to their offspring, with maternal effect genes being critical regulators of the offspring epigenome.
Natalia Benetti +7 more
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Modeling epigenetic evolutionary algorithms: An approach based on the epigenetic regulation process [PDF]
arXiv, 2021 Many biological processes have been the source of inspiration for heuristic methods that generate high-quality solutions to solve optimization and search problems. This thesis presents an epigenetic technique for Evolutionary Algorithms, inspired by the epigenetic regulation process, a mechanism to better understand the ability of individuals to adapt ...
arxiv
Drawing a Waddington landscape to capture dynamic epigenetics [PDF]
Biol. Cell. 105, 576-584 (2013), 2016 Epigenetics is most often reduced to chromatin marking in the current literature, whereas this notion was initially defined in a more general context. This restricted view ignores that epigenetic memories are in fact more robustly ensured in living systems by steady state mechanisms with permanent molecule renewal.
arxiv +1 more source