Results 11 to 20 of about 475,691 (380)
Epigenetics-targeted drugs: current paradigms and future challenges
Signal Transduction and Targeted TherapyEpigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone modification, RNA modification, chromatin remodeling, and non-coding RNA regulation.
Wanlin Dai +11 more
doaj +2 more sources
New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine [PDF]
DiagnosticsFollowing the application of epigenetic and epigenomics research into tumor diseases, cardiovascular disease, diabetes, hereditary diseases, and rare diseases, in vitro diagnostics (IVD) epigenetic and epigenomics are increasingly employed for those ...
Pengtao Song, Biaoru Li
doaj +2 more sources
The Social Brain Meets the Reactive Genome: Neuroscience, Epigenetics and the New Social Biology [PDF]
Frontiers in Human Neuroscience, 2014 The rise of molecular epigenetics over the last few years promises to bring the discourse about the sociality and susceptibility to environmental influences of the brain to an entirely new level.
Maurizio eMeloni
doaj +5 more sources
Epigenetics and depression
 [PDF]
Dialogues in Clinical Neuroscience, 2019 The risk for major depression is both genetically and environmentally determined. It has been proposed that epigenetic mechanisms could mediate the lasting increases in depression risk following exposure to adverse life events and provide a mechanistic ...
Signe Penner-Goeke, E. Binder
semanticscholar +4 more sources
Proceedings of the National Academy of Sciences, 2013 In higher eukaryotic organisms epigenetic modifications are crucial for proper chromatin folding and thereby proper regulation of gene expression. Epigenetics include DNA methylation, histone modifications, and microRNAs. First described in tumors, the involvement of aberrant epigenetic modifications has been reported also in other diseases, i.e ...
Steffen Gay, Michel Neidhart
openaire +3 more sources
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Signal Transduction and Targeted Therapy, 2023 Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout, hyperthyroidism, hypothyroidism and others.
Yan-Lin Wu +9 more
doaj +1 more source
Introduction to Epigenetics [PDF]
, 2021 Learning Materials in ...
Paro, Renato +3 more
openaire +3 more sources
Indian Journal of Medical and Paediatric Oncology, 2020 Historically, cancer is known to be a genetic disease. It is now realized that it involves epigenetic abnormalities along with genetic alterations. Epigenetics is an extra layer of instruction that lies upon DNA and controls how the genes are read and ...
Ravi Jaiswal, Esha Jafa
doaj +3 more sources
Cancer epigenetics in clinical practice
Ca, 2022 Cancer development is driven by the accumulation of alterations affecting the structure and function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic alterations contribute to the acquisition of hallmark tumor capabilities by ...
V. Davalos, M. Esteller
semanticscholar +1 more source