Results 21 to 30 of about 221,982 (189)
The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region [PDF]
, 2019 BACKGROUND: The cell-cycle inhibitor p57kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types.
Andresini, Oriella +5 more
core +4 more sources
Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors. [PDF]
, 2014 BackgroundIn 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether decitabine increased expression of ...
A Kumari +55 more
core +2 more sources
Genes to Cells, 2012 Induced pluripotent stem (iPS) cells have provided a rational means of obtaining histo‐compatible tissues for ‘patient‐specific’ regenerative therapies (Hanna et al. 2010; Yamanaka & Blau 2010). Despite the obvious potential of iPS cell‐based therapies, there are certain problems that must be overcome before these therapies can become safe and ...
Manukyan, Maria, Singh, Prim B
openaire +2 more sources
Current Medicinal Chemistry, 2019 Epigenetics controls the expression of genes and is responsible for cellular phenotypes. The fundamental basis of these mechanisms involves in part the post-translational modifications (PTMs) of DNA and proteins, in particular, the nuclear histones. DNA can be methylated or demethylated on cytosine.
Blanquart, Christophe +5 more
openaire +5 more sources
Molecular Cell, 2001 In the November 15 issue of Nature, report that disruption of histone methylation in the fungus Neurospora crassa results in the elimination of DNA methylation. This demonstrates that chromatin structure can pattern DNA methylation and suggests that different epigenetic layers engage in complex crosstalk.
Ben-Porath, Ittai, Cedar, Howard
openaire +2 more sources
From early stress to 12-month development in very preterm infants: Preliminary findings on epigenetic mechanisms and brain growth [PDF]
, 2018 Very preterm (VPT) infants admitted to Neonatal Intensive Care Unit (NICU) are at risk for altered brain growth and less-than-optimal socio-emotional development.
Borgatti, R. +13 more
core +1 more source
Epigenetics and immunometabolism in diabetes and aging [PDF]
, 2018 Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation.
Cosentino, Francesco, Guzik, Tomasz J.
core +2 more sources
Nature Communications, 2020 Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound enhancer-promoter interactions is a key mechanism underlying endocrine resistance.
Joanna Achinger-Kawecka +18 more
doaj +1 more source
Role of epigenetics in cardiovascular diseases: An out and out check
Intelligent Pharmacy, 2023 Epigenetics is a rapidly growing field that deals with the study of heritable changes in gene expression that occur without a change in DNA sequence.
Rufaida Wasim +5 more
doaj +1 more source
Teaching & Learning Inquiry: The ISSOTL Journal, 2020 Mental health researchers emphasize the importance of practitioner understanding of biology-environment interplay. Accordingly, our goal of the study described in this article was to understand students’ preconceptions and misconceptions about biological
Kate E. Snyder +3 more
doaj +1 more source