Results 21 to 30 of about 175,767 (313)

Computational epigenetics [PDF]

Bioinformatics, 2007
Abstract Epigenetic research aims to understand heritable gene regulation that is not directly encoded in the DNA sequence. Epigenetic mechanisms such as DNA methylation and histone modifications modulate the packaging of the DNA in the nucleus and thereby influence gene expression.
Bock, C., Lengauer, T.
openaire   +4 more sources

Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer

Nature Communications, 2020
Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound enhancer-promoter interactions is a key mechanism underlying endocrine resistance.
Joanna Achinger-Kawecka, Fatima Valdes-Mora, Phuc-Loi Luu, Katherine A. Giles, C. Elizabeth Caldon, Wenjia Qu, Shalima Nair, Sebastian Soto, Warwick J. Locke, Nicole S. Yeo-Teh, Cathryn M. Gould, Qian Du, Grady C. Smith, Irene R. Ramos, Kristine F. Fernandez, Dave S. Hoon, Julia M. W. Gee, Clare Stirzaker, Susan J. Clark   +18 more
doaj   +1 more source

Lowly methylated region analysis identifies EBF1 as a potential epigenetic modifier in breast cancer

Epigenetics, 2017
Breast cancer (BC) encompasses heterogeneous pathologies with different subtypes exhibiting distinct molecular changes, including those related to DNA methylation.
Nora Fernandez-Jimenez, Athena Sklias, Szilvia Ecsedi, Vincent Cahais, Davide Degli-Esposti, Antonin Jay, Pierre Benoit Ancey, Hae Dong Woo, Hector Hernandez-Vargas, Zdenko Herceg   +9 more
doaj   +1 more source

Epigenetics Regulates Antitumor Immunity in Melanoma

Frontiers in Immunology, 2022
Melanoma is the most malignant skin cancer, which originates from epidermal melanocytes, with increasing worldwide incidence. The escape of immune surveillance is a hallmark of the tumor, which is manifested by the imbalance between the enhanced immune ...
Yuhan Chen, Yuhan Chen, Xiuli Yi, Ningyue Sun, Ningyue Sun, Weinan Guo, Chunying Li   +6 more
doaj   +1 more source

Epigenetics of Meningiomas [PDF]

BioMed Research International, 2015
Meningiomas account for one-third of all adult central nervous system tumours and are divided into three WHO grades. In contrast to the relatively well characterized genetic alterations, our current understanding of epigenetic modifications involved in the meningioma-genesis and progression is rather incomplete.
Murnyák, Balázs, Bognár, László, Klekner, Álmos, Hortobágyi, Tibor   +3 more
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Epigenetics and sarcoidosis [PDF]

European Respiratory Review, 2021
Epigenetic modifications are emerging as important regulatory mechanisms of gene expression in lung disease, given that they are influenced by environmental exposures and genetic variants, and that they regulate immune and fibrotic processes. In this review, we introduce these concepts with a focus on the study of DNA methylation and histone ...
Ivana V. Yang, Ivana V. Yang, Iain R. Konigsberg, Lisa A. Maier, Lisa A. Maier   +4 more
openaire   +2 more sources

Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA

Epigenetics & Chromatin, 2017
Background The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping the mammalian DNA methylation ...
Ksenia Skvortsova, Elena Zotenko, Phuc-Loi Luu, Cathryn M. Gould, Shalima S. Nair, Susan J. Clark, Clare Stirzaker   +6 more
doaj   +1 more source

Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer

Nature Communications, 2019
The connection between DNA replication timing and changes that occur to the epigenome in cancer are still poorly understood. Here, the authors perform Repli-Seq and integrated epigenome analyses and find that genomic regions that undergo long-range ...
Qian Du, Saul A. Bert, Nicola J. Armstrong, C. Elizabeth Caldon, Jenny Z. Song, Shalima S. Nair, Cathryn M. Gould, Phuc-Loi Luu, Timothy Peters, Amanda Khoury, Wenjia Qu, Elena Zotenko, Clare Stirzaker, Susan J. Clark   +13 more
doaj   +1 more source

“Epic-Genetics”: An exploration of preservice helping professionals’ (mis)understanding of epigenetic influences on human development

Teaching & Learning Inquiry: The ISSOTL Journal, 2020
Mental health researchers emphasize the importance of practitioner understanding of biology-environment interplay. Accordingly, our goal of the study described in this article was to understand students’ preconceptions and misconceptions about biological
Kate E. Snyder, Caroline M. Pittard, Allison Fowler, Corey T. Watson   +3 more
doaj   +1 more source

The danger of epigenetics misconceptions (epigenetics and stuff…) [PDF]

Biochemistry and Cell Biology, 2015
Within the past two decades, the fields of chromatin structure and function and transcription regulation research started to fuse and overlap, as evidence mounted to support a very strong regulatory role in gene expression that was associated with histone post-translational modifications, DNA methylation, as well as various chromatin-associated ...
openaire   +4 more sources