Results 31 to 40 of about 458,162 (417)
The Epigenetic Cytocrin Pathway to the Nucleus. Epigenetic Factors, Epigenetic Mediators, and Epigenetic Traits. A Biochemist Perspective [PDF]
Frontiers in Genetics, 2017 A single word, Epigenetics, underlies one exciting subject in today's Science, with different sides and with interactions with philosophy. The apparent trivial description includes everything in between genotype and phenotype that occurs for a given unique DNA sequence/genome.
Gemma Navarro +5 more
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Epigenetics: What it is about? [PDF]
, 2014 Epigenetics has captured the attention of scientists in the past decades, yet its scope has been continuously changing. In this paper, we give an overview on how and why its definition has evolved and suggest several clarification on the concepts used in
Ogryzko, Vasily, Saade, Evelyne
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Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups
Epigenetics & Chromatin, 2019 Background ATP-dependent chromatin remodelling complexes are responsible for establishing and maintaining the positions of nucleosomes. Chromatin remodellers are targeted to chromatin by transcription factors and non-coding RNA to remodel the chromatin ...
Katherine A. Giles +9 more
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Epigenetics of Meningiomas [PDF]
BioMed Research International, 2015 Meningiomas account for one-third of all adult central nervous system tumours and are divided into three WHO grades. In contrast to the relatively well characterized genetic alterations, our current understanding of epigenetic modifications involved in the meningioma-genesis and progression is rather incomplete.
Murnyák, Balázs +3 more
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Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention. [PDF]
, 2020 Environmental and lifestyle factors are believed to account for >80% of breast cancers; however, it is not well understood how and when these factors affect risk and which exposed individuals will actually develop the disease.
Park, Hannah Lui
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Nature Communications, 2020 Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound enhancer-promoter interactions is a key mechanism underlying endocrine resistance.
Joanna Achinger-Kawecka +18 more
doaj +1 more source
Lowly methylated region analysis identifies EBF1 as a potential epigenetic modifier in breast cancer
Epigenetics, 2017 Breast cancer (BC) encompasses heterogeneous pathologies with different subtypes exhibiting distinct molecular changes, including those related to DNA methylation.
Nora Fernandez-Jimenez +9 more
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Epigenetics Regulates Antitumor Immunity in Melanoma
Frontiers in Immunology, 2022 Melanoma is the most malignant skin cancer, which originates from epidermal melanocytes, with increasing worldwide incidence. The escape of immune surveillance is a hallmark of the tumor, which is manifested by the imbalance between the enhanced immune ...
Yuhan Chen +6 more
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Computational epigenetics [PDF]
Bioinformatics, 2007 Abstract Epigenetic research aims to understand heritable gene regulation that is not directly encoded in the DNA sequence. Epigenetic mechanisms such as DNA methylation and histone modifications modulate the packaging of the DNA in the nucleus and thereby influence gene expression.
Bock, C., Lengauer, T.
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Epigenetics and sarcoidosis [PDF]
European Respiratory Review, 2021 Epigenetic modifications are emerging as important regulatory mechanisms of gene expression in lung disease, given that they are influenced by environmental exposures and genetic variants, and that they regulate immune and fibrotic processes. In this review, we introduce these concepts with a focus on the study of DNA methylation and histone ...
Ivana V. Yang +4 more
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