Results 31 to 40 of about 369,301 (351)
Nature Communications, 2020 Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound enhancer-promoter interactions is a key mechanism underlying endocrine resistance.
Joanna Achinger-Kawecka +18 more
doaj +1 more source
The Roles of Epigenetics Regulation in Bone Metabolism and Osteoporosis
Frontiers in Cell and Developmental Biology, 2021 Osteoporosis is a metabolic disease characterized by decreased bone mineral density and the destruction of bone microstructure, which can lead to increased bone fragility and risk of fracture.
Fei Xu +5 more
semanticscholar +1 more source
Epigenetics for Crop Improvement in Times of Global Change
Biology, 2021 Simple Summary Research on plant epigenetics aims to understand how endogenous, biotic, and abiotic factors regulate plant development and growth independent of changes in the genome sequence.
I. Kakoulidou +12 more
semanticscholar +1 more source
The Epigenetic Cytocrin Pathway to the Nucleus. Epigenetic Factors, Epigenetic Mediators, and Epigenetic Traits. A Biochemist Perspective [PDF]
Frontiers in Genetics, 2017 A single word, Epigenetics, underlies one exciting subject in today's Science, with different sides and with interactions with philosophy. The apparent trivial description includes everything in between genotype and phenotype that occurs for a given unique DNA sequence/genome.
Gemma Navarro +5 more
openaire +6 more sources
Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups
Epigenetics & Chromatin, 2019 Background ATP-dependent chromatin remodelling complexes are responsible for establishing and maintaining the positions of nucleosomes. Chromatin remodellers are targeted to chromatin by transcription factors and non-coding RNA to remodel the chromatin ...
Katherine A. Giles +9 more
doaj +1 more source
Epigenetics in the pathogenesis of diabetic nephropathy
Acta Biochimica et Biophysica Sinica, 2021 Diabetic nephropathy (DN), which is a common microvascular complication with a high incidence in diabetic patients, greatly increases the mortality of patients.
Xue Li +7 more
semanticscholar +1 more source
Epigenetics of Meningiomas [PDF]
BioMed Research International, 2015 Meningiomas account for one-third of all adult central nervous system tumours and are divided into three WHO grades. In contrast to the relatively well characterized genetic alterations, our current understanding of epigenetic modifications involved in the meningioma-genesis and progression is rather incomplete.
Murnyák, Balázs +3 more
openaire +3 more sources
Lowly methylated region analysis identifies EBF1 as a potential epigenetic modifier in breast cancer
Epigenetics, 2017 Breast cancer (BC) encompasses heterogeneous pathologies with different subtypes exhibiting distinct molecular changes, including those related to DNA methylation.
Nora Fernandez-Jimenez +9 more
doaj +1 more source
Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA
Epigenetics & Chromatin, 2017 Background The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping the mammalian DNA methylation ...
Ksenia Skvortsova +6 more
doaj +1 more source
Epigenetics and sarcoidosis [PDF]
European Respiratory Review, 2021 Epigenetic modifications are emerging as important regulatory mechanisms of gene expression in lung disease, given that they are influenced by environmental exposures and genetic variants, and that they regulate immune and fibrotic processes. In this review, we introduce these concepts with a focus on the study of DNA methylation and histone ...
Ivana V. Yang +4 more
openaire +2 more sources