Results 41 to 50 of about 369,301 (351)
Epigenetics Regulates Antitumor Immunity in Melanoma
Frontiers in Immunology, 2022 Melanoma is the most malignant skin cancer, which originates from epidermal melanocytes, with increasing worldwide incidence. The escape of immune surveillance is a hallmark of the tumor, which is manifested by the imbalance between the enhanced immune ...
Yuhan Chen +6 more
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Nature Communications, 2019 The connection between DNA replication timing and changes that occur to the epigenome in cancer are still poorly understood. Here, the authors perform Repli-Seq and integrated epigenome analyses and find that genomic regions that undergo long-range ...
Qian Du +13 more
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Clinical Epigenetics, 2021 Despite impressive efforts invested in epigenetic research in the last 50 years, clinical applications are still lacking. Only a few university hospital centers currently use epigenetic biomarkers at the bedside.
Federica Sarno +18 more
semanticscholar +1 more source
Current Medicinal Chemistry, 2019 Epigenetics controls the expression of genes and is responsible for cellular phenotypes. The fundamental basis of these mechanisms involves in part the post-translational modifications (PTMs) of DNA and proteins, in particular, the nuclear histones. DNA can be methylated or demethylated on cytosine.
Blanquart, Christophe +5 more
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Machine learning and clinical epigenetics: a review of challenges for diagnosis and classification
Clinical Epigenetics, 2020 Machine learning is a sub-field of artificial intelligence, which utilises large data sets to make predictions for future events. Although most algorithms used in machine learning were developed as far back as the 1950s, the advent of big data in ...
S. Rauschert +5 more
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Maternal SMCHD1 regulates Hox gene expression and patterning in the mouse embryo
Nature Communications, 2022 Parents transmit both genetic and epigenetic information to their offspring, with maternal effect genes being critical regulators of the offspring epigenome.
Natalia Benetti +7 more
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Cold Spring Harbor Perspectives in Medicine, 2017 Organisms with identical genome sequences can show substantial differences in their phenotypes owing to epigenetic changes that result in different use of their genes. Epigenetic regulation of gene expression plays a key role in the control of several fundamental processes in the biology of malaria parasites, including antigenic variation and sexual ...
Cortés, Alfred, Deitsch, Kirk W.
openaire +3 more sources
A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
Nature Communications, 2019 PWWP domains of DNMT3A and DNMT3B are proposed to interact with H3K36me3. Here the authors present a mouse model carrying a D329A point mutation in the DNMT3A PWWP domain and find this causes dominant postnatal growth retardation, with aberrant ...
Gintarė Sendžikaitė +4 more
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Cancer epigenetics: from laboratory studies and clinical trials to precision medicine
Cell Death DiscoveryEpigenetic dysregulation is a common feature of a myriad of human diseases, particularly cancer. Defining the epigenetic defects associated with malignant tumors has become a focus of cancer research resulting in the gradual elucidation of cancer cell ...
Xinyang Yu +7 more
semanticscholar +1 more source
Teaching & Learning Inquiry: The ISSOTL Journal, 2020 Mental health researchers emphasize the importance of practitioner understanding of biology-environment interplay. Accordingly, our goal of the study described in this article was to understand students’ preconceptions and misconceptions about biological
Kate E. Snyder +3 more
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