Results 41 to 50 of about 189,865 (294)
The danger of epigenetics misconceptions (epigenetics and stuff…) [PDF]
Biochemistry and Cell Biology, 2015 Within the past two decades, the fields of chromatin structure and function and transcription regulation research started to fuse and overlap, as evidence mounted to support a very strong regulatory role in gene expression that was associated with histone post-translational modifications, DNA methylation, as well as various chromatin-associated ...
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Ayurveda and Epigenetics [PDF]
Medicina, 2020 Ayurveda is a comprehensive, natural health care system that originated in the ancient Vedic times of India. Epigenetics refers to the external modification of DNA that turns genes on and off, affecting gene expression. This occurs without changes in the basic structure of the DNA. This gene expression can have transgenerational effects.
Hari Sharma, Robert Keith Wallace
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Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
The Social Brain Meets the Reactive Genome: Neuroscience, Epigenetics and the New Social Biology
Frontiers in Human Neuroscience, 2014 The rise of molecular epigenetics over the last few years promises to bring the discourse about the sociality and susceptibility to environmental influences of the brain to an entirely new level.
Maurizio eMeloni
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Will epigenetics ever be a biosocial science? A reply to Chiapperino and Paneni
Epigenetics Communications, 2023 The recent correspondence article by Chiapperino and Paneni in Clinical Epigenetics correctly points to the inability of epigenetics to incorporate fine-grained mapping data of the individual’s surrounding milieu.
Silvio Zaina
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Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
Nature Communications, 2019 PWWP domains of DNMT3A and DNMT3B are proposed to interact with H3K36me3. Here the authors present a mouse model carrying a D329A point mutation in the DNMT3A PWWP domain and find this causes dominant postnatal growth retardation, with aberrant ...
Gintarė Sendžikaitė +4 more
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An Epigenetic Role of Mitochondria in Cancer
Cells, 2022 Mitochondria are not only the main energy supplier but are also the cell metabolic center regulating multiple key metaborates that play pivotal roles in epigenetics regulation.
Yu’e Liu +6 more
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Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease–Associated Colorectal Cancer [PDF]
, 2021 Kristiina Rajamäki +25 more
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The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source