Epigenetics of Meningiomas [PDF]
BioMed Research International, 2015 Meningiomas account for one-third of all adult central nervous system tumours and are divided into three WHO grades. In contrast to the relatively well characterized genetic alterations, our current understanding of epigenetic modifications involved in the meningioma-genesis and progression is rather incomplete.
Murnyák, Balázs +3 more
openaire +3 more sources
Epigenetics and sarcoidosis [PDF]
European Respiratory Review, 2021 Epigenetic modifications are emerging as important regulatory mechanisms of gene expression in lung disease, given that they are influenced by environmental exposures and genetic variants, and that they regulate immune and fibrotic processes. In this review, we introduce these concepts with a focus on the study of DNA methylation and histone ...
Ivana V. Yang +4 more
openaire +2 more sources
Lowly methylated region analysis identifies EBF1 as a potential epigenetic modifier in breast cancer
Epigenetics, 2017 Breast cancer (BC) encompasses heterogeneous pathologies with different subtypes exhibiting distinct molecular changes, including those related to DNA methylation.
Nora Fernandez-Jimenez +9 more
doaj +1 more source
Epigenetics for Crop Improvement in Times of Global Change
Biology, 2021 Simple Summary Research on plant epigenetics aims to understand how endogenous, biotic, and abiotic factors regulate plant development and growth independent of changes in the genome sequence.
I. Kakoulidou +12 more
semanticscholar +1 more source
The Roles of Epigenetics Regulation in Bone Metabolism and Osteoporosis
Frontiers in Cell and Developmental Biology, 2021 Osteoporosis is a metabolic disease characterized by decreased bone mineral density and the destruction of bone microstructure, which can lead to increased bone fragility and risk of fracture.
Fei Xu +5 more
semanticscholar +1 more source
Exercise epigenetics and the foetal origins of disease [PDF]
, 2014 Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age).
Dale E, Thomas EW Chalk, William M Brown
core +1 more source
Epigenetics in the pathogenesis of diabetic nephropathy
Acta Biochimica et Biophysica Sinica, 2021 Diabetic nephropathy (DN), which is a common microvascular complication with a high incidence in diabetic patients, greatly increases the mortality of patients.
Xue Li +7 more
semanticscholar +1 more source
Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI [PDF]
, 2017 Background: Global epigenetic reprogramming is considered to be essential during embryo development to establish totipotency. In the classic model first described in the mouse, the genome-wide DNA demethylation is asymmetric between the paternal and the ...
De Schauwer, Catharina +3 more
core +1 more source
Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer [PDF]
, 2020 Increased numbers of myeloid-derived suppressor cells (MDSCs) are positively correlated with poor prognosis and reduced survivals of cancer patients. They play central roles in tumor immune evasion and tumor metastasis.
Abu Nada, M +9 more
core +3 more sources
Epigenetics Regulates Antitumor Immunity in Melanoma
Frontiers in Immunology, 2022 Melanoma is the most malignant skin cancer, which originates from epidermal melanocytes, with increasing worldwide incidence. The escape of immune surveillance is a hallmark of the tumor, which is manifested by the imbalance between the enhanced immune ...
Yuhan Chen +6 more
doaj +1 more source