Results 51 to 60 of about 495,214 (384)

Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer

Nature Communications, 2020
Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound enhancer-promoter interactions is a key mechanism underlying endocrine resistance.
Joanna Achinger-Kawecka, Fatima Valdes-Mora, Phuc-Loi Luu, Katherine A. Giles, C. Elizabeth Caldon, Wenjia Qu, Shalima Nair, Sebastian Soto, Warwick J. Locke, Nicole S. Yeo-Teh, Cathryn M. Gould, Qian Du, Grady C. Smith, Irene R. Ramos, Kristine F. Fernandez, Dave S. Hoon, Julia M. W. Gee, Clare Stirzaker, Susan J. Clark   +18 more
doaj   +1 more source

What is a Gene? A Two Sided View [PDF]

, 2017
The need to account for all currently available experimental observations concerning the gene nature, has reshaped the concept of gene turning it from the essentially mechanistic unit, predominant during the '70s, into a quite abstract open ...
Bolondi, A., Caldarelli, F., Camilloni, Giorgio, DI FELICE, Francesca, Durano, Diletta, Germani, G., Micheli, G., Michetti, L., Tramutolo, A.   +8 more
core   +1 more source

The physics of epigenetics

, 2016
In higher organisms, all cells share the same genome, but every cell expresses only a limited and specific set of genes that defines the cell type. During cell division, not only the genome, but also the cell type is inherited by the daughter cells. This
Barbi, Maria, Caré, Bertrand R., Cortini, Ruggero, Lavelle, Christophe, Lesne, Annick, Mozziconacci, Julien, Victor, Jean-Marc   +6 more
core   +3 more sources

DNMTs are required for delayed genome instability caused by radiation [PDF]

, 2012
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited ...
Anderson, RM, Armstrong, CA, Iyer, P, Jones, GD, Narayanan, D, Sandhu, J, Singh, R, Talbot, CJ, Talbot, CJ, Tufarelli, C, Tufarelli, C   +10 more
core   +2 more sources

Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer

Nature Communications, 2019
The connection between DNA replication timing and changes that occur to the epigenome in cancer are still poorly understood. Here, the authors perform Repli-Seq and integrated epigenome analyses and find that genomic regions that undergo long-range ...
Qian Du, Saul A. Bert, Nicola J. Armstrong, C. Elizabeth Caldon, Jenny Z. Song, Shalima S. Nair, Cathryn M. Gould, Phuc-Loi Luu, Timothy Peters, Amanda Khoury, Wenjia Qu, Elena Zotenko, Clare Stirzaker, Susan J. Clark   +13 more
doaj   +1 more source

DNA methylation and DNA methyltransferases [PDF]

, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +3 more sources

Cancer epigenetics: from laboratory studies and clinical trials to precision medicine

Cell Death Discovery
Epigenetic dysregulation is a common feature of a myriad of human diseases, particularly cancer. Defining the epigenetic defects associated with malignant tumors has become a focus of cancer research resulting in the gradual elucidation of cancer cell ...
Xinyang Yu, Hao Zhao, Ruiqi Wang, Yingyin Chen, Xumei Ouyang, Wenting Li, Yihao Sun, Anghui Peng   +7 more
semanticscholar   +1 more source

Epigenetic Mechanisms [PDF]

, 2011
The incidence of diabetes and related complications like nephropathy is growing rapidly and has become a major health care issue. Changes in the environment and nutritional habits have been implicated as major players. Furthermore, it is becoming increasingly clear that epigenetic factors may modulate the connections between genes and the environment ...
Louisa M, Villeneuve, Rama, Natarajan
openaire   +2 more sources

Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors. [PDF]

, 2014
BackgroundIn 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether decitabine increased expression of ...
A Kumari, AS Yang, C Festuccia, C Zeller, CA Stidley, CJ Piyathilake, D Ma, D Matei, D Shang, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DW Shen, E Gordian, E San Jose-Eneriz, EA Braga, F Crea, F Fang, H Iwata, H Kantarjian, H Kroeger, HM Kantarjian, J Charlet, J Shia, JA Plumb, JP Issa, JP Issa, JS Kim, K Ghoshal, K Onda, K Ramachandran, K Tikoo, KY Tse, L Ding, L Rothem, MA Kane, ML Orta, NH Nabilsi, R Zhao, RH Finnell, S Fu, S Vijayaraghavalu, SB Baylin, SS Muerkoster, T Tanaka, TB Lee, VF Chekhun, X Chang, XJ Liang, Y Li, Y Oki, Y Zhang, ZG Liu   +55 more
core   +2 more sources

From 1957 to Nowadays: A Brief History of Epigenetics

International Journal of Molecular Sciences, 2020
Due to the spectacular number of studies focusing on epigenetics in the last few decades, and particularly for the last few years, the availability of a chronology of epigenetics appears essential.
P. Peixoto, P. Cartron, Aurélien A. Sérandour, E. Hervouet   +3 more
semanticscholar   +1 more source