Results 161 to 170 of about 86,342 (328)
Childhood Asthma and Allergy Are Related to Accelerated Epigenetic Aging
Allergy, EarlyView.We used a pediatric epigenetic clock to assess epigenetic age in children from a German birth cohort. Accelerated epigenetic aging was found to be related to the presence of allergic diseases like asthma, rhinitis, or eczema, but not to non‐symptomatic aeroallergen sensitization. This was supported by an epigenetic age acceleration gradient in response
Miriam Leskien +11 more
wiley +1 more source
Human Molecular Genetics, 2002 Research in cancer epigenomics is driven by the development of novel technologies and the utilization of model organisms ranging from yeasts to plants to vertebrates. For decades, the search for cancer genes has focused on genetic defects that were used as tags for identification of these genes.
openaire +2 more sources
Detection of Epigenomic Network Community Oncomarkers [PDF]
arXiv, 2015 In this paper we propose network methodology to infer prognostic cancer biomarkers based on the epigenetic pattern DNA methylation. Epigenetic processes such as DNA methylation reflect environmental risk factors, and are increasingly recognised for their fundamental role in diseases such as cancer.
arxiv
The use of deidentified organ donor testes for research
Andrology, EarlyView.Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova +4 more
wiley +1 more source
Applications of spatial transcriptomics in studying spermatogenesis
Andrology, EarlyView.Abstract Spermatogenesis is a complex differentiation process that is facilitated by a series of cellular and molecular events. High‐throughput genomics approaches, such as single‐cell RNA sequencing, have begun to enable the systematic characterization of these events. However, the loss of tissue context because of tissue disassociations in the single‐
Qianlan Xu, Haiqi Chen
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley +1 more source
Tasks and Visual Abstractions for 3D Chromatin Representation
Computer Graphics Forum, EarlyView.Abstract The spatial organization of chromatin fiber directly influences its function. However, the high visual complexity of chromatin spatial models makes the understanding of the structure extremely challenging. Therefore, genomic researchers still primarily rely on indirect analysis of chromatin through 2D views, missing the advantages that 3D ...
A. Rychlý +3 more
wiley +1 more source
An Introduction to Causal Inference Methods with Multi-omics Data [PDF]
arXivOmics biomarkers play a pivotal role in personalized medicine by providing molecular-level insights into the etiology of diseases, guiding precise diagnostics, and facilitating targeted therapeutic interventions. Recent advancements in omics technologies have resulted in an increasing abundance of multimodal omics data, providing unprecedented ...
arxiv
DNA methylation associated with postpartum depressive symptoms overlaps findings from a genome-wide association meta-analysis of depression [PDF]
, 2019 Background Perinatal depressive symptoms have been linked to adverse maternal and infant health outcomes. The etiology associated with perinatal depressive psychopathology is poorly understood, but accumulating evidence suggests that understanding inter ...
Kinser, Patricia A. +5 more
core +1 more source