Results 181 to 190 of about 93,647 (322)

Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice. [PDF]

Nat Commun
Horii T, Morita S, Hino S, Hino Y, Fukushima HS, Kobayashi R, Kimura M, Nakao M, Mizukami Y, Inoue A, Hatada I.   +10 more
europepmc   +1 more source

Decision letter: H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

, 2018

openalex   +1 more source

PRISM‐xQTL: Pleiotropic Relationships Integrated with System‐level Multiomic QTL analysis for causal genes and molecular mediators in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Most Alzheimer's disease (AD) risk variants identified by genome‐wide association studies (GWAS) reside in noncoding regions, complicating causal interpretation. METHODS We developed PRISM‐xQTL (Pleiotropic Relationships Integrated with System‐level Multiomic QTL), integrating pleiotropy, co‐localization, Mendelian randomization ...
Nitesh Enduru, Zhongming Zhao
wiley   +1 more source

Rescue of imprinted genes by epigenome editing in human cellular models of Prader-Willi syndrome. [PDF]

Nat Commun
Nemoto A, Imaizumi K, Miya F, Hiroi Y, Yamada M, Ideno H, Saitoh S, Kosaki K, Okuno H, Okano H.   +9 more
europepmc   +1 more source

Genomes and Epigenomes: Beyond the DNA sequence [PDF]

, 2009
Beulé, Thierry, Jaligot, Estelle, Rival, Alain, Tregear, James   +3 more
core  

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source

First Indonesian Nasopharyngeal Cancer Whole Epigenome Sequencing Identify Tumour Suppressor CpG Methylation

Biologics: Targets & Therapy
Handoko,1– 3 Marlinda Adham,2,4 Lisnawati Rachmadi,2,5 Demak Lumban Tobing,6 Asmarinah,7 Fadilah,8 Wei Dai,9,10 Anne Wing Mui Lee,10 Soehartati A Gondhowiardjo2,3 1Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia ...
Handoko, Adham M, Rachmadi L, Tobing DL, Asmarinah A, Fadilah F, Dai W, Lee AWM, Gondhowiardjo SA   +8 more
doaj  

MOESM7 of Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

, 2019
Ryuichiro Nakato, Youichiro Wada, Ryo Nakaki, Genta Nagae, Yuki Katou, Shuichi Tsutsumi, Natsu Nakajima, Hiroshi Fukuhara, Atsushi Iguchi, Takahide Kohro, Yasuharu Kanki, Yutaka Saitō, Mika Kobayashi, Akashi Izumi-Taguchi, Naoki Osato, Kenji Tatsuno, Asuka Kamio, Yoko Hayashi‐Takanaka, Hiromi Wada, Shinzo Ohta, Masanori Aikawa, Hiroyuki Nakajima, Masaki Nakamura, Rebecca J. McGee, Kyle Heppner, Tatsuo Kawakatsu, Michiru Genno, Hiroshi Yanase, Haruki Kume, Takaaki Senbonmatsu, Yukio Homma, Shigeyuki Nishimura, Toutai Mitsuyama, Hiroyuki Aburatani, Hiroshi Kimurâ, Katsuhiko Shirahige   +35 more
openalex   +1 more source

Epigenetic Applications in Adverse Outcome Pathways and Chemical Risk Evaluation [PDF]

, 2017
Allard, P, Angrish, M, Chadwick, LH, Chorley, BN, Hines, E, McCullough, SD   +5 more
core  

Single‐cell sequencing for cancer precision medicine: From mechanism discovery to diagnosis and therapeutics

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Single‐cell sequencing overcomes bulk sequencing limitations, enabling high‐resolution multi‐omics analysis at the single‐cell level. It reveals tumour heterogeneity, identifying key subpopulations and tumour microenvironment interactions driving progression and resistance.
Yue Zhao, Hancong Li, Huanzuo Yang, Gongshuang Zhang, Xinyue Fu, Peiheng Li, Puxing He, Shuang Wu, Han Luo   +8 more
wiley   +1 more source