Results 181 to 190 of about 87,804 (313)

Epigenetic diet: impact on the epigenome and cancer [PDF]

, 2011
Tabitha M. Hardy, Trygve O. Tollefsbol
openalex   +1 more source

Neocortical neurogenesis: a proneural gene perspective

The FEBS Journal, EarlyView.
The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan, Alexandra Moffat, Pierre Mattar, Carol Schuurmans   +3 more
wiley   +1 more source

Frontiers in Toxicogenomics – The Grand Challenge: To Understand How the Genome and Epigenome Interact with the Toxic Environment [PDF]

, 2011
Douglas M. Ruden
openalex   +1 more source

Overcoming BET‐inhibitor JQ1 resistance in aggressive non‐small cell lung cancer by inducing ferroptosis via inhibition of the BRD2–FTH1 axis

The FEBS Journal, EarlyView.
Recent studies emphasize alternative functions of FTH1 relevant for nuclear processes, such as transcriptional regulation. This study shows a novel FTH1/BRD2 association in non‐small cell lung carcinoma (NSCLC). This nuclear interaction affects BRD2 protein stability in aggressive NSCLC cells.
Stefania Scicchitano, Cinzia Garofalo, Beatrice Stella, Gianluca Santamaria, Flora Cozzolino, Vittoria Monaco, Flavia Biamonte, Maria Monti, Eleonora Vecchio, Maria Concetta Faniello   +9 more
wiley   +1 more source

Genomic Investigation of Dedifferentiated Liposarcoma Suggests a Role for Therapeutic Targeting of the Tumor Epigenome [PDF]

, 2011
Paul S. Meltzer, Lee J. Helman
openalex   +1 more source

Gaining insights into epigenetic memories through artificial intelligence and omics science in plants

Journal of Integrative Plant Biology, EarlyView.
This review explores how artificial intelligence and machine learning predict plant behavior in response to environmental stress by modeling molecular regulatory networks of plant stress responses. Their combined application with omics methods opens new avenues in understanding the functioning of plant memory and future plant memory‐based plant ...
Judit Dobránszki, Valya Vassileva, Dolores R. Agius, Panagiotis Nikolaou Moschou, Philippe Gallusci, Margot M.J. Berger, Dóra Farkas, Marcos Fernando Basso, Federico Martinelli   +8 more
wiley   +1 more source

Epigenetic reprogramming in the germline: towards the ground state of the epigenome [PDF]

, 2011
Petra Hájková
openalex   +1 more source

Maternal high fat and high sugar diet impacts on key DNA methylation enzymes in offspring brain in a sex‐specific manner

Journal of Neuroendocrinology, EarlyView.
Abstract Maternal obesity associates with an increased risk of offspring neurodevelopmental disorders. Although the underlying mechanism(s) remain unclear, evidence suggests a role for altered DNA methylation. We utilized a murine model of diet‐induced obesity to investigate the impact of maternal obesity on the offspring brain transcriptome and DNA ...
Kahyee Hor, Laura Dearden, Emily Herzstein, Susan Ozanne, Giles Hardingham, Amanda J. Drake   +5 more
wiley   +1 more source

How mitochondrial DNA-driven changes to chromosomal DNA methylation add a layer of complexity to mitochondrial disease [PDF]

, 2019
De Paepe, Boel
core   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source