Results 91 to 100 of about 64,265 (410)

Immune repertoire: Revealing the “real-time” adaptive immune response in autoimmune diseases

Autoimmunity, 2021
The diversity of the immune repertoire (IR) enables the human immune system to distinguish multifarious antigens (Ags) that humans may encounter throughout life.
Meiyu Wu, Ming Zhao, Haijing Wu, Qianjin Lu   +3 more
doaj   +1 more source

What is a Gene? A Two Sided View [PDF]

, 2017
The need to account for all currently available experimental observations concerning the gene nature, has reshaped the concept of gene turning it from the essentially mechanistic unit, predominant during the '70s, into a quite abstract open ...
Bolondi, A., Caldarelli, F., Camilloni, Giorgio, DI FELICE, Francesca, Durano, Diletta, Germani, G., Micheli, G., Michetti, L., Tramutolo, A.   +8 more
core   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. [PDF]

, 2013
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially ...
Abecasis, GR, Ackerman, MJ, Adamkova, V, Alonso, A, Arking, DE, Arnar, DO, Asselbergs, FW, Bader, JS, Barc, J, Bardai, A, Beckmann, BM, Behr, ER, Bezzina, CR, Bis, JC, Bobbo, M, Boyer, LA, Bradford, Y, Brandimarto, J, Brion, M, Brown, M, Campbell, H, Cappola, TP, CARe Consortium, Carella, M, Carracedo, A, Caulfield, MJ, Chakravarti, A, Chatel, S, COGENT Consortium, Crotti, L, Cummings, SR, D'Adamo, AP, Dalageorgou, C, Daly, MJ, DCCT/EDIC, de Bakker, PI, de Boer, RA, del Greco M, F, den Hoed, M, Denny, JC, Dominiczak, AF, Dörr, M, Ehret, G, Eijgelsheim, M, Eisele, L, El Mokhtari, NE, Ellinghaus, D, eMERGE Consortium, Emilsson, V, Erbel, R, Evans, DS, Felix, SB, Ferrucci, L, Franco, OH, Franke, A, Franke, L, Frey, N, Fuchsberger, C, Gasparini, P, Ghidoni, A, Gieger, C, Giudicessi, JR, Greiser, KH, Griffin, M, Gudbjartsson, DF, Gudnason, V, Gustafsson, S, Haerting, J, Hamilton, RM, Harris, TB, Hayward, C, Heckbert, SR, Hicks, AA, Hingorani, AD, Hoffmann, P, Hofman, A, Hofman, N, HRGEN Consortium, Huang, H, Hubacek, JA, Hólm, H, Ingelsson, E, Insolia, R, Iorio, A, Isaacs, A, Jamshidi, Y, Johnson, AD, Jula, A, Jöckel, KH, Kao, WH, Kedenko, L, Kellis, M, Kiechl, S, Kivimaki, M, Kluttig, A, Knoflach, M, Kolcic, I, Kontula, KK, Koopmann, TT, Kors, JA, Krijthe, BP, Kronenberg, F, Kumar, RD, Kumari, M, Kyndt, F, Kähönen, M, Kälsch, H, Kääb, S, Lage, K, Lahtinen, AM, Lakatta, EG, Lamina, C, Larson, MG, Launer, LJ, Lee, WK, Lehtimäki, TJ, Lind, L, Liu, Y, Loos, RJ, Lundby, A, Lyytikäinen, LP, Macfarlane, PW, Margulies, K, Marjamaa, A, Markus, MR, Martens, E, Mateo Leach, I, Medeiros-Domingo, A, Meitinger, T, Meyer Zu Schwabedissen, H, Mononen, N, Moravec, CE, Morley, M, Morris, RW, Mulas, A, Munroe, PB, Mühleisen, TW, Müller-Nurasyid, M, Nalls, MA, Naluai, ÅT, Navarro, P, Navis, G, Newhouse, SJ, Newton-Cheh, C, Nicolaides, AN, Nolte, IM, Noseworthy, PA, Nyberg, F, Nöthen, MM, O'Connell, JR, O'Donnell, CJ, Oikarinen, L, Olsen, JV, Oostra, BA, Orrú, M, Padmanabhan, S, Panayiotou, AG, Parsa, A, Paterson, AD, Paulweber, B, Perola, M, Perz, S, Peters, A, Pfeufer, A, Plump, AS, Polašek, O, Porthan, K, Post, WS, Pramstaller, PP, Probst, V, Prucha, H, Psaty, BM, Pulit, SL, Raitakari, OT, Raychaudhuri, S, Ritchie, MD, Roden, DM, Rossin, EJ, Rotter, JI, Rudan, I, Salomaa, V, Samani, NJ, Sanna, S, Scherer, SW, Schlessinger, D, Schott, JJ, Schwartz, PJ, Shuldiner, AR, Sinagra, G, Sinner, MF, Siscovick, DS, Slowikowski, K, Smith, AV, Smith, JG, Snieder, H, Sotoodehnia, N, Spector, TD, Stefansson, K, Strait, JB, Stricker, BH, Strohmer, B, Sundström, J, Syvänen, AC, Tanaka, T, Tarasov, KV, Tester, DJ, Thelle, DS, Thorsteinsdottir, U, Torres, M, Uda, M, Uitterlinden, AG, Ulivi, S, van den Berg, MP, van der Harst, P, van der Vleuten, PA, van Duijn, CM, van Veldhuisen, DJ, Viikari, JS, Völker, U, Waggott, D, Waldenberger, M, Wang, X, Watt, GC, Werdan, K, Whincup, PH, Wild, SH, Wilde, AA, Willeit, J, Wilson, JF, Witteman, JC, Wright, AF, Yin, X, Zelante, L, Zuvich, RL, Ärnlöv, J   +234 more
core   +6 more sources

AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1–Bcl-6 axis-mediated B-cell differentiation

Signal Transduction and Targeted Therapy, 2021
Absent in melanoma 2 (AIM2) has been reported to be a component of inflammasomes in innate immune cells. Surprisingly, AIM2 is expressed by B cells, and higher AIM2 expression is observed in the B cells from lupus patients.
Ming Yang, Di Long, Longyuan Hu, Zhidan Zhao, Qianwen Li, Yunkai Guo, Zhenghao He, Ming Zhao, Liwei Lu, Fen Li, Hai Long, Haijing Wu, Qianjin Lu   +12 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Understanding the Interplay Between Health Disparities and Epigenomics

Frontiers in Genetics, 2020
Social epigenomics has emerged as an integrative field of research focused on identification of socio-environmental factors, their influence on human biology through epigenomic modifications, and how they contribute to current health disparities. Several
Viviana J. Mancilla, Noah C. Peeri, T. Silzer, R. Basha, M. Felini, H. Jones, N. Phillips, M. Tao, S. Thyagarajan, J. Vishwanatha   +9 more
semanticscholar   +1 more source

Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding

Nature Communications, 2019
Functional variants have been proposed to alter transcription factor binding. Here, the authors provide direct evidence that functional variants within the TBC1D4 gene, encoding an NFκB binding site, can alter transcription factor binding, and use CRISPR-
Andrew D. Johnston, Claudia A. Simões-Pires, Taylor V. Thompson, Masako Suzuki, John M. Greally   +4 more
doaj   +1 more source

Epigenomics and Chromatin Dynamics [PDF]

, 2014
A report of the 'Joint Keystone Symposium on Epigenomics and Chromatin Dynamics', Keystone, Colorado, 17-22 January 2012. This year's Joint Keystone Symposium on Epigenomics and Chromatin Dynamics was one of the largest Keystone meetings to date ...
Akopian, Veronika, Chan, Michelle, Clement, Kendell, Galonska, Christina, Gifford, Casey, Lehtola, Elizabeth, Liao, Jing, Meissner, Alexander, Samavarchi-Tehrani, Payman, Sindhu, Camille, Smith, Zachary D, Tsankov, Alexander, Webster, Jamie Orme, Zhang, Yingying, Ziller, Michael Johannes   +14 more
core   +1 more source

Vitamin D and the epigenome [PDF]

Frontiers in Physiology, 2014
Epigenetic mechanisms play a crucial role in regulating gene expression. The main mechanisms involve methylation of DNA and covalent modifications of histones by methylation, acetylation, phosphorylation, or ubiquitination. The complex interplay of different epigenetic mechanisms is mediated by enzymes acting in the nucleus.
Irfete S. Fetahu, E. Kállay, Julia Höbaus   +2 more
openaire   +4 more sources