Results 91 to 100 of about 43,487 (351)

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism

Advanced Science, EarlyView.
The SNP rs2863002 at the 11p11.2 locus, identified through GWAS, is associated with an increased risk of neuroblastoma. The rs2863002‐C allele impairs the binding of the transcription factor GATA3, resulting in upregulation of the HSD17B12 gene.
Teresa Maiorino, Marianna Avitabile, Vincenzo Aievola, Annalaura Montella, Vito A. Lasorsa, Ferdinando Bonfiglio, Mariagrazia Cantalupo, Sueva Cantalupo, Gilda Estinto, Matilde Tirelli, Martina Morini, Martina Ardito, Alessandra Eva, Vincenza Cerbone, Lucia Mauriello, Marianna Caterino, Margherita Ruoppolo, John M. Maris, Sharon J. Diskin, Achille Iolascon, Mario Capasso   +20 more
wiley   +1 more source

Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies

BMC Oral Health, 2021
Background Systemic sclerosis (SSc) is a multisystem rheumatic disease. Orofacial manifestations are commonly in SSc but maybe usually ignored and overshadowed by other systemic complications.
Suhan Zhang, Junfei Zhu, Yanshan Zhu, Xiaochao Zhang, Ruifang Wu, Siying Li, Yuwen Su   +6 more
doaj   +1 more source

From Code to Life: The AI‐Driven Revolution in Genome Editing

Advanced Science, EarlyView.
This review explores AI‐driven advancements in genome editing, focusing on CRISPR optimization, enhanced targeting precision, reduced off‐target effects, and novel tool design. It addresses ethical challenges, data biases, and highlights future prospects in precision medicine, agriculture, and synthetic biology.
Zhidong Li, Wasi Ullah Khan, Genxiang Bai, Chao Dong, Jungang Wang, Youpeng Zhang, Chong Wang, Hongbin Zhang, Wenyi Wang, Ming Luo, Fei Chen   +10 more
wiley   +1 more source

Epigenomics in environmental health

Frontiers in Genetics, 2011
This review considers the emerging relationships between environmental factors and epigenetic alterations and the application of genome-wide assessments to better define these relationships.
Carmen J Marsit, Brock C Christensen
doaj   +1 more source

Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet

Nutrients, 2020
The Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits.
F. Caradonna, O. Consiglio, C. Luparello, C. Gentile   +3 more
semanticscholar   +1 more source

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source

Comparative epigenomics: an emerging field with breakthrough potential to understand evolution of epigenetic regulation

AIMS Genetics, 2014
Epigenetic mechanisms regulate gene expression, thereby mediating the interaction between environment, genotype and phenotype. Changes to epigenetic regulation of genes may be heritable, permitting rapid adaptation of a species to environmental cues ...
Janine E. Deakin, Renae Domaschenz, Pek Siew Lim, Tariq Ezaz, Sudha Rao   +4 more
doaj   +1 more source

Epigenetics and Epigenomics: Implications for Diabetes and Obesity

Diabetes, 2018
The American Diabetes Association convened a research symposium, “Epigenetics and Epigenomics: Implications for Diabetes and Obesity” on 17–19 November 2017.
E. Rosen, K. Kaestner, R. Natarajan, M. Patti, Richard C. Sallari, M. Sander, K. Suszták   +6 more
semanticscholar   +1 more source

Epigenomics and genotype-phenotype association analyses reveal conserved genetic architecture of complex traits in cattle and human

BMC Biology, 2020
Lack of comprehensive functional annotations across a wide range of tissues and cell types severely hinders the biological interpretations of phenotypic variation, adaptive evolution, and domestication in livestock.
Shuli Liu, Ying Yu, Shengli Zhang, J. Cole, A. Tenesa, Ting Wang, T. McDaneld, Li Ma, G. Liu, L. Fang   +9 more
semanticscholar   +1 more source

Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway

Advanced Science, EarlyView.
A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li, Zhen Shao, Jinsong Li, Naihe Jing, Xianfa Yang   +16 more
wiley   +1 more source