Results 91 to 100 of about 55,460 (328)

Beyond the genome and into the clinic. [PDF]

, 2012
A report of BioMed Central's third annual Beyond the Genome conference, held at Harvard Medical School, Boston, September 27-29 ...
Segal, David J
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SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks

Advanced Science, EarlyView.
SCRIPT is a novel method inferring single‐cell cis‐regulatory relationships (CRRs) from transcriptomic and chromatin accessibility data. SCRIPT incorporates two key innovations: graph causal attention networks supported by empirical CRR evidence, and representation learning enhanced through pretraining on atlas‐scale single‐cell data.
Yu Zhang, Baole Wen, Yifeng Jiao, Yuchen Liu, Xin Guo, Yushuai Wu, Jiyang Li, Limei Han, Yinghui Xu, Xin Gao, Yuan Qi, Yuan Cheng, Ying He, Weidong Tian   +13 more
wiley   +1 more source

How chronic inflammation fuels carcinogenesis as an environmental epimutagen

Discover Oncology
Chronic inflammation, induced by environmental and intrinsic factors, frequently leads to carcinogenesis. In inflammation-associated cancers, such as gastric, colon, and cervical cancers, an important role of epigenetic alterations has been implicated ...
Yu-Yu Liu, Yui Ohashi, Toshikazu Ushijima   +2 more
doaj   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients. [PDF]

, 2015
BACKGROUND: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell ...
Aittomäki, Kristiina, Alnæs, Grethe G, Behrens, Sabine, Blomqvist, Carl, Bolla, Manjeet K., Børresen-Dale, Anne-Lise, Chang-Claude, Jenny, Couch, Fergus J., Dunning, Alison M., Easton, Doug F, Fagerholm, Rainer, Flesch-Janys, Dieter, Hall, Per, Hamann, Ute, Hartikainen, Jaana M., Hollestelle, Antoinette, Hooning, Maartje J, Humphreys, Keith, Jager, Agnes, Kabisch, Maria, Kataja, Vesa, Kosma, Veli-Matti, Kristensen, Vessela, Lambrechts, Diether, Li, Jingmei, Liu, Jianjun, Mannermaa, Arto, Margolin, Sara, Michailidou, Kyriaki, Nevanlinna, Heli, Nord, Silje, Pharoah, Paul, Popanda, Odilia, Purrington, Kristen S, Rhenius, Valerie, Schildkraut, Joellen M, Schmezer, Peter, Schmidt, Marjanka K., Seibold, Petra, Seynaeve, Caroline, Shah, Mitul, Torres, Diana, Ulmer, Hans-Ulrich, Wang, Qin, Wildiers, Hans   +44 more
core   +4 more sources

Megasphaera Elesdenii Dysregulates Colon Epithelial Homeostasis, Aggravates Colitis‐Associated Tumorigenesis

Advanced Science, EarlyView.
A fecal microbial meta‐analysis reveals that Megasphaera is highly abundant in the Asian population with IBD and CRC. M. elsdenii reshapes colonic immunity by triggering DC cell‐mediated Th1 and Th17 inflammation. M. elsdenii and M. elsdenii‐enriched microbiota exacerbate colonic inflammation and tumorigenesis in AOM/DSS mice.
Xinxin Hou, Zhaozhou Zhang, Wanqing Chen, Jinming Li, Xiangxiang Zhu, Mingjie Li, Xiaoqi Guan, Haidong Guo, Yanlei Ma, Ling Zhao   +9 more
wiley   +1 more source

Synthesizing the role of epigenetics in the response and adaptation of species to climate change in freshwater ecosystems [PDF]

, 2018
Freshwater ecosystems are amongst the most threatened ecosystems on Earth. Currently, climate change is one of the most important drivers of freshwater transformation and its effects include changes in the composition, biodiversity and functioning of ...
Allen, Allendorf, Alley, Andrewartha, Anway, Araújo, Ardura, Artemov, Asselman, Asselman, Avise, Baccarelli, Baerwald, Baudo, Bell, Berg, Bernardi, Bernstein, Bianchini, Bind, Bird, Bird, Blake, Bossdorf, Boutin, Brander, Bräutigam, Burggren, Bush, Carpenter, Cañedo-Argüelles, Chown, Clarke, Corcoran, Crozier, Dai, Dallas, Daxinger, Denissenko, Detrich, Dudgeon, Durance, Eros, Fasola, Feil, Fenoglio, Foley, Friberg, Fulneček, Garg, Gienapp, Glastad, Goldberg, Gonçalves, Guillette, Hanson, Harris, Heino, Henry, Hering, Hernando-Herraez, Ho, Hoegh-Guldberg, Hoffmann, Hu, Jabbari, Jablonka, Jackson, Jackson, Jaenisch, Janssens, Jiang, Karell, Karr, Kefford, Keller, Kelly, Klimenko, Klironomos, Kouzarides, Kronholm, Kronholm, Kumar, Kurdyukov, Laland, Laland, Lan, Latta, Leung, Lighten, Liu, Loureiro, Loureiro, Lämke, Manjrekar, Markovic, Martinez-Sales, Martínez-Jerónimo, Matthews, Mattick, Meissner, Mendizabal, Merilä, Merilä, Michener, Mimura, Minshull, Mirbahai, Mohseni, Moore, Mudbhary, Mulholland, Munday, Nabel, Nielsen, Norouzitallab, Parichy, Park, Pestana, Peterson, Pigliucci, Pigliucci, Pu, Qu, Rey, Ribeiro, Rinn, Ryan, Sarda, Scheiner, Scheiner, Schindler, Schrey, Shaw, Shea, Solan, Srinageshwar, Stief, Sun, Suter, Suzuki, Szabo, Sáez, Urich, Vandegehuchte, Vandegehuchte, Vannier, Varriale, Varriale, Varriale, Venâncio, Verhoeven, Verhoeven, Vogt, Vogt, Vogt, Wang, Wang, Weider, Weinberg, Weyrich, Willbanks, Williams, Wong, Woodward, Woodward, WWAP   +166 more
core   +1 more source

Super‐Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation

Advanced Science, EarlyView.
A novel chromatin‐labeling probe is developed to investigate chromatin mobility during differentiation. The silicon rhodamine–conjugated dCTP is efficiently delivered into iPSCs and NSCs using a synthetic transporter. Super‐resolution microscopy and single‐particle tracking show decreased chromatin mobility during differentiation.
Maruthi K. Pabba, Miroslav Kuba, Tomáš Kraus, Kerem Celikay, Janis Meyer, Sunil Kumar Pradhan, Andreas Maiser, Hartmann Harz, Heinrich Leonhardt, Karl Rohr, Michal Hocek, M. Cristina Cardoso   +11 more
wiley   +1 more source

Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies

BMC Oral Health, 2021
Background Systemic sclerosis (SSc) is a multisystem rheumatic disease. Orofacial manifestations are commonly in SSc but maybe usually ignored and overshadowed by other systemic complications.
Suhan Zhang, Junfei Zhu, Yanshan Zhu, Xiaochao Zhang, Ruifang Wu, Siying Li, Yuwen Su   +6 more
doaj   +1 more source

Novel Techniques and Their Applications to Health Foods, Agricultural and Medical Biotechnology: Functional Genomics and Basic Epigenetic Controls in Plant and Animal Cells [PDF]

, 2004
Selected applications of novel techniques for analyzing Health Food formulations, as well as for advanced investigations in Agricultural and Medical Biotechnology aimed at defining the multiple connections between functional genomics and epigenomic ...
Baianu, I.C., Lin, H.C., Lozano, P., Prisecaru, V. I.   +3 more
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