Results 101 to 110 of about 64,265 (410)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research [PDF]

, 2011
Epigenetics is the study of all mechanisms that regulate gene transcription and genome stability that are maintained throughout the cell division, but do not include the DNA sequence itself.
A Hellman, A Zemach, AK Maunakea, AP Bird, C Tufarelli, D Aran, D Takai, D Zilberman, E Hodges, E Segal, EN Gal-Yam, H Cedar, H Han, HH Ng, J M Flanagan, JA Yoder, JD Lieb, JF Smith, JK Choi, JK Choi, JM Flanagan, JM Flanagan, JT Huff, K Appleton, K Flower, KR Blahnik, L Nanty, L Wild, M Lorincz, M Weber, MA Hahn, MA Hahn, MG Guenther, MJ Carrozza, MM Suzuki, MP Ball, N Shenker, PA Jones, R Appanah, RD Hawkins, S Feng, S Fu, TA Rauch, TE Fandy, V Rishi, VM Komashko, VM Komashko, WA Schulz, X Zhang, Y Li, YJ Shann   +50 more
core   +1 more source

Fetal Akinesia/Hypokinesia and Arthrogryposis of Neuromuscular Origin: Etiologic Groups, Genetics, and Phenotypic Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive clinical and genetic characterization of individuals with arthrogryposis multiplex congenita (AMC), focusing on the distribution of genetic etiologies across the neuromuscular spectrum and comparing myogenic and neurogenic subtypes. Methods A total of 105 individuals with AMC were clinically and genetically
Florencia Pérez‐Vidarte, Berta Estévez‐Arias, Leslie Matalonga, Delia Yubero, Anna Codina, Carlos Ortez, Julita Medina, Lidia DeSena DeCabo, Laura Carrera‐García, Jesica Expósito‐Escudero, Cristina Jou, Eduardo F. Tizzano, Andres Nascimento, Daniel Natera‐de Benito   +13 more
wiley   +1 more source

Epigenomic language models powered by Cerebras [PDF]

arXiv, 2021
Large scale self-supervised pre-training of Transformer language models has advanced the field of Natural Language Processing and shown promise in cross-application to the biological `languages' of proteins and DNA. Learning effective representations of DNA sequences using large genomic sequence corpuses may accelerate the development of models of gene
arxiv  

Implementing Curcumin in Translational Oncology Research

Molecules, 2020
Most data published on curcumin and curcumin-based formulations are very promising. In cancer research, the majority of data has been obtained in vitro. Less frequently, researchers used experimental animals.
Koraljka Gall Trošelj, Ivana Samaržija, Marko Tomljanović, Renata Novak Kujundžić, Nikola Đaković, Anamarija Mojzeš   +5 more
doaj   +1 more source

Ferroptosis Activation Contributes to the Formation of Skin Lesions in Psoriasis Vulgaris

Antioxidants, 2023
(1) Background: Ferroptosis is a newly coined form of programmed cell death marked by lethal accumulation of lipid peroxidation and ferrous iron overload.
Siying Li, Xin Luo, Suhan Zhang, Yuwen Su, Min Deng, Yanshan Zhu, Peng Zhang, Ruifang Wu, Ming Zhao   +8 more
doaj   +1 more source

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Higher order methylation features for clustering and prediction in epigenomic studies [PDF]

Bioinformatics (2016) 32 (17): i405-i412, 2016
Motivation: DNA methylation is an intensely studied epigenetic mark, yet its functional role is incompletely understood. Attempts to quantitatively associate average DNA methylation to gene expression yield poor correlations outside of the well-understood methylation-switch at CpG islands.
arxiv   +1 more source

Comparative epigenomics: an emerging field with breakthrough potential to understand evolution of epigenetic regulation

AIMS Genetics, 2014
Epigenetic mechanisms regulate gene expression, thereby mediating the interaction between environment, genotype and phenotype. Changes to epigenetic regulation of genes may be heritable, permitting rapid adaptation of a species to environmental cues ...
Janine E. Deakin, Renae Domaschenz, Pek Siew Lim, Tariq Ezaz, Sudha Rao   +4 more
doaj   +1 more source

Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies

BMC Oral Health, 2021
Background Systemic sclerosis (SSc) is a multisystem rheumatic disease. Orofacial manifestations are commonly in SSc but maybe usually ignored and overshadowed by other systemic complications.
Suhan Zhang, Junfei Zhu, Yanshan Zhu, Xiaochao Zhang, Ruifang Wu, Siying Li, Yuwen Su   +6 more
doaj   +1 more source