Microbiome, 2023 Background The intestinal epithelial barrier confers protection against the intestinal invasion by pathogens and exposure to food antigens and toxins. Growing studies have linked the gut microbiota to the intestinal epithelial barrier function.
Jun Hu +5 more
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Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coliSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2017 Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
Ali Shawki, Declan F. McCole
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The epithelial barrier: a Janus-faced regulator in allergic airway diseases from defense to inflammation [PDF]
Frontiers in AllergyBackgroundThe epithelial barrier serves as the body's first line of defense between the host immune system and the external environment. Evidence confirms that epithelial barrier damage is an initial event in the pathogenesis of allergic respiratory ...
Youwei Bao +3 more
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Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease [PDF]
Allergy, 2022 Environmental exposure plays a major role in the development of allergic diseases. The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external (e.g., chemical pollutants or lifestyle factors), and ...
Zeynep Celebi Sozener +14 more
semanticscholar +5 more sources
The involvement of Th17 inflammation and miR-363-3p in airway epithelial barrier dysfunction [PDF]
Respiratory ResearchBackground Impaired airway epithelial barrier function is a pathogenic driver in a subset of individuals with asthma. MicroRNAs, small RNAs that function as post-transcriptional regulators of gene expression, may be involved in the regulation of the ...
Cecilia Lässer +9 more
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Deciphering the Complex Signaling Systems That Regulate Intestinal Epithelial Cell Death Processes and Shedding [PDF]
Frontiers in Immunology, 2017 Intestinal epithelial cells play a fundamental role in maintaining homeostasis. Shedding of intestinal cells in a controlled manner is critical to maintenance of barrier function.
Angela M. Patterson +3 more
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A Direct Effect of Sex Hormones on Epithelial Barrier Function in Inflammatory Bowel Disease Models
Cells, 2019 Background: Pregnancy is often described as an immune-tolerant state, and a disease modulatory role for pregnancy on inflammatory bowel disease (IBD) has been suggested.
Janine van der Giessen +3 more
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Budesonide promotes airway epithelial barrier integrity following double-stranded RNA challenge.
PLoS ONE, 2021 Airway epithelial barrier dysfunction is increasingly recognized as a key feature of asthma and other lung diseases. Respiratory viruses are responsible for a large fraction of asthma exacerbations, and are particularly potent at disrupting epithelial ...
Clara Rimmer +4 more
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Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage [PDF]
, 2015 Aminosalicylates, corticosteroids and immunosuppressants are currently the therapeutic choices in inflammatory bowel diseases (IBD), however, with limited remission and often serious side effects.
Brun, Paola +10 more
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Chinese Medical Journal, 2022 . Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis, allergic asthma, atopic dermatitis, and chronic rhinosinusitis with nasal polyps.
Xiang Dong +8 more
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