Results 1 to 10 of about 428,146 (135)

Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coliSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2017
Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
Ali Shawki, Declan F. McCole
doaj   +3 more sources

Deciphering the Complex Signaling Systems That Regulate Intestinal Epithelial Cell Death Processes and Shedding [PDF]

Frontiers in Immunology, 2017
Intestinal epithelial cells play a fundamental role in maintaining homeostasis. Shedding of intestinal cells in a controlled manner is critical to maintenance of barrier function.
Angela M. Patterson, Angela M. Patterson, Alastair J. M. Watson, Alastair J. M. Watson   +3 more
doaj   +4 more sources

The epithelial barrier: a Janus-faced regulator in allergic airway diseases from defense to inflammation [PDF]

Frontiers in Allergy
BackgroundThe epithelial barrier serves as the body's first line of defense between the host immune system and the external environment. Evidence confirms that epithelial barrier damage is an initial event in the pathogenesis of allergic respiratory ...
Youwei Bao, Qi Chen, Binbin Shi, Xinhua Zhu   +3 more
doaj   +2 more sources

The involvement of Th17 inflammation and miR-363-3p in airway epithelial barrier dysfunction [PDF]

Respiratory Research
Background Impaired airway epithelial barrier function is a pathogenic driver in a subset of individuals with asthma. MicroRNAs, small RNAs that function as post-transcriptional regulators of gene expression, may be involved in the regulation of the ...
Cecilia Lässer, Elisabeth Ax, Julie Weidner, Sofia Winslow, Hannes Ingelhag, Jenny Calvén, Carina Malmhäll, Zala Jevnikar, Henric Olsson, Madeleine Rådinger   +9 more
doaj   +2 more sources

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier [PDF]

Advanced Science
Strict regulation of epithelial cells is crucial for maintaining intestinal barrier integrity and preventing intestinal diseases. While transcriptional regulation is well recognized as vital in this process, translational regulation is equally important.
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
doaj   +2 more sources

Novel Food Supplement Containing a Combination of Postbiotics and Plant-Derived Compounds Regulates Epithelial Barrier Integrity and Immune Response in Human Enterocytes [PDF]

Foods
Background: Alterations of epithelial barrier integrity and immune response play a key role in the pathogenesis of allergic diseases and represent promising targets for nutritional interventions. Selected postbiotics and plant-derived compounds have been
Franca Oglio, Serena Coppola, Alessia Cadavere, Roberta Di Santillo, Vittoria Mauriello, Marco Michelini, Raffaele Federico Iorio, Erika Caldaria, Laura Carucci   +8 more
doaj   +2 more sources

Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes. [PDF]

, 2013
Anopheline mosquitoes are the primary vectors of parasites in the genus Plasmodium, the causative agents of malaria. Malaria parasites undergo a series of complex transformations upon ingestion by the mosquito host.
Camp, Lauren, Luckhart, Shirley, Nadler, Steven A, Pakpour, Nazzy, Smithers, Hannah M, Tu, Zhijian, Wang, Bo   +6 more
core   +24 more sources

Budesonide promotes airway epithelial barrier integrity following double-stranded RNA challenge.

PLoS ONE, 2021
Airway epithelial barrier dysfunction is increasingly recognized as a key feature of asthma and other lung diseases. Respiratory viruses are responsible for a large fraction of asthma exacerbations, and are particularly potent at disrupting epithelial ...
Clara Rimmer, Savas Hetelekides, Sophia I Eliseeva, Steve N Georas, Janelle M Veazey   +4 more
doaj   +3 more sources

Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma

Chinese Medical Journal, 2022
. Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis, allergic asthma, atopic dermatitis, and chronic rhinosinusitis with nasal polyps.
Xiang Dong, Mei Ding, Jinjin Zhang, Ismail Ogülür, Yagiz Pat, Mübeccel Akdis, Yadong Gao, Cezmi A. Akdis, Peifang Wei   +8 more
doaj   +1 more source

Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling

Microbiome, 2023
Background The intestinal epithelial barrier confers protection against the intestinal invasion by pathogens and exposure to food antigens and toxins. Growing studies have linked the gut microbiota to the intestinal epithelial barrier function.
Jun Hu, Jianwei Chen, Xiaojian Xu, Qiliang Hou, Jing Ren, Xianghua Yan   +5 more
doaj   +1 more source