Results 31 to 40 of about 2,478,278 (345)

Epithelial barrier dysfunction in bronchial asthma

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2022
The pathogenesis of bronchial asthma is based on chronic inflammation as a response to etiological factors. It causes bron-chial hyperreactivity, remodeling of the respiratory tract and hypersecretion of mucus.
R. N. Khramova, T. I. Eliseeva, T. E. Potemina   +2 more
doaj   +1 more source

Chloride channels regulate differentiation and barrier functions of the mammalian airway. [PDF]

, 2020
The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
Caplan, Michael J, Chen, Yuzhang, Darmanis, Spyros, He, Mu, Jan, Lily Yeh, Jan, Yuh Nung, Le, Daniel D, Li, Ke-Xin, Neff, Norma, Padovano, Valeria, Sinclair, Adriane W, Sit, Rene, Tan, Michelle, Wu, Bing, Ye, Wenlei   +14 more
core   +2 more sources

Plasma polymerized bio-interface directs fibronectin adsorption and functionalization to enhance “epithelial barrier structure” formation via FN-ITG β1-FAK-mTOR signaling cascade

Biomaterials Research, 2022
Background Transepithelial medical devices are increasing utilized in clinical practices. However, the damage of continuous natural epithelial barrier has become a major risk factor for the failure of epithelium-penetrating implants. How to increase the “
Shoucheng Chen, Zhuwei Huang, Rahul Madathiparambil Visalakshan, Haiwen Liu, Akash Bachhuka, You Wu, Panthihage Ruvini L. Dabare, Pu Luo, Runheng Liu, Zhuohong Gong, Yin Xiao, Krasimir Vasilev, Zhuofan Chen, Zetao Chen   +13 more
doaj   +1 more source

A Novel Non-invasive Method to Detect RELM Beta Transcript in Gut Barrier Related Changes During a Gastrointestinal Nematode Infection [PDF]

, 2019
Currently, methods for monitoring changes of gut barrier integrity and the associated immune response via non-invasive means are limited. Therefore, we aimed to develop a novel non-invasive technique to investigate immunological host responses ...
Affinass, Nicole, Ahmed, Norus, Hartmann, Susanne, Heitlinger, Emanuel, Jarquin, Victor Hugo, Jost, Jenny, Kühl, Anja A., Steinfelder, Svenja, Xenophontos, Natasa   +8 more
core   +4 more sources

Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells [PDF]

, 2019
Intestinal epithelial barrier function in celiac disease (CeD) patients is altered. However, the mechanism underlying this effect is not fully understood.
Branchi, Federica, Cardoso-Silva, Danielle, Delbue, Deborah, Itzlinger, Alice, Letizia, Marilena, Schumann, Michael, Siegmund, Britta   +6 more
core   +1 more source

Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip [PDF]

, 2015
The intestinal epithelium is a critical component of the gut barrier. Composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, this delicate structure prevents the transfer of harmful microorganisms, antigens ...
A. J. M. Watson, B. J. Campbell, Beaulieu JF, Brown CC, C. A. Duckworth, Casellas F, D. M. Pritchard, Gelberg HB, J. M. Williams, Kaur P, Lee JS, Lobo SM, M. D. Burkitt, Mayhew TM, Moore R, Peschon JJ   +15 more
core   +4 more sources

Sinapic Acid Alleviated Inflammation-Induced Intestinal Epithelial Barrier Dysfunction in Lipopolysaccharide- (LPS-) Treated Caco-2 Cells

Mediators of Inflammation, 2021
The integrity and permeability of the intestinal epithelial barrier are important indicators of intestinal health. Impaired intestinal epithelial barrier function and increased intestinal permeability are closely linked to the onset and progression of ...
H. Lan, Lu-Ying Zhang, Wen He, Wanying Li, Zhen Zeng, Bo Qian, Chengqiang Wang, Jia-Le Song   +7 more
semanticscholar   +1 more source

Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease

EBioMedicine, 2022
Summary: Background: Loss of intestinal epithelial barrier integrity is a critical component of Inflammatory Bowel Disease (IBD) pathogenesis. Co-expression regulation of ligand-receptor pairs in IBD mucosa has not been systematically studied. Targeting
Yang Cheng, Tyler R. Hall, Xiao Xu, Ivy Yung, Donald Souza, Jie Zheng, Felix Schiele, Matthias Hoffmann, M. Lamine Mbow, James P. Garnett, Jun Li   +10 more
doaj   +1 more source

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. [PDF]

, 2018
Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking.
Bayrer, James R, Escusa, Hazel S, Fletterick, Robert J, Ingraham, Holly A, Klein, Ophir D, Moore, David D, Nattiv, Roy, Suzawa, Miyuki, Wang, Hongtao   +8 more
core   +2 more sources

Epithelial barrier hypothesis and the development of allergic and autoimmune diseases

Allergo Journal International, 2022
The “epithelial barrier hypothesis” proposes that genetic predisposition to epithelial barrier damage, exposure to various epithelial barrier–damaging agents and chronic periepithelial inflammation are responsible for the development of allergic and ...
D. Yazici, I. Ogulur, Ozan C Kucukkase, Manru Li, Arturo O. Rinaldi, Yagiz Pat, A. Wallimann, Sebastian Wawrocki, Zeynep Celebi Sozener, B. Buyuktiryaki, C. Saçkesen, M. Akdiş, Y. Mitamura, C. Akdis   +13 more
semanticscholar   +1 more source