Results 301 to 310 of about 921,216 (339)

Cadherin profiling for therapeutic interventions in Epithelial Mesenchymal Transition (EMT) and tumorigenesis

Experimental Cell Research, 2018
The major hallmarks of Epithelial‐Mesenchymal Transition (EMT) is the loss of epithelial cell polarity and loss of expression of the cell‐ cell adhesion molecule like E‐cadherin and acquired mesenchymal cells marker called N‐Cadherin.
Mintu Pal, Sourya Bhattacharya, Gazal Kalyan, Saugata Hazra   +3 more
semanticscholar   +1 more source

Epithelial Cell Shape: Cadherins and Small GTPases

Experimental Cell Research, 2000
Cadherins are cell-cell adhesion receptors that are essential for the establishment of the epithelial cell shape and maintenance of the differentiated epithelial phenotype. In order to show efficient adhesion, cadherin receptors require an association with actin filaments and the activity of RHO proteins.
openaire   +2 more sources

Differential expression of neural‐cadherin in pulmonary epithelial tumours

Histopathology, 2008
Aims:  Neural (N)‐cadherin belongs to a group of transmembrane molecules with a crucial role in tissue morphogenesis and maintenance of an epithelioid phenotype and increased N‐cadherin expression is implicated in tumour progression and dedifferentiation.
D L, Zynger, N D, Dimov, L C, Ho, W B, Laskin, A V, Yeldandi   +4 more
openaire   +2 more sources

Brg1 inhibits E-cadherin expression in lung epithelial cells and disrupts epithelial integrity

Journal of Molecular Medicine, 2017
Brahma-related gene-1 (Brg1), a key chromatin remodeling factor, is associated with cell proliferation and migration in kidney and heart cells, but few reports have examined its role in airway epithelial cell. Airway epithelial injury, which is involved in the entire pathological process of asthma, is an important cause of recurrent asthma.
Ting, Wang, Wenjing, Zou, Chao, Niu, Fengxia, Ding, Yaping, Wang, Shuang, Cai, Hua, Zhu, Daiyin, Tian, Jihong, Dai, Enmei, Liu, Qing, Lu, Zhou, Fu, Lin, Zou   +12 more
openaire   +2 more sources

Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia

American Journal of Physiology-Renal Physiology, 2000
Ischemic epithelial cells are characterized by disruption of intercellular junctions and loss of apical-basolateral protein polarity, which are normally dependent on the integrity of the adherens junction (AJ). Biochemical analysis of both whole ischemic kidneys and ATP-depleted Madin-Darby canine kidney (MDCK) cells demonstrated a striking loss of E ...
K T, Bush, T, Tsukamoto, S K, Nigam
openaire   +2 more sources

Epithelial cadherins and associated molecules in invasive lobular breast cancer

Arkhiv patologii, 2017
to estimate the expression of cell adhesion molecules E- and P-cadherin, as well as that of cadherin-catenin complexes in invasive lobular breast cancer (BC) cells.250 cases of postoperative material from patients diagnosed with invasive lobular BC were studied. The expressions of cell adhesion molecules E-cadherin, P-cadherin, β-catenin, p120 catenin,
Yu M, Brilliant, A A, Brilliant, S V, Sazonov   +2 more
openaire   +2 more sources

Mutant cadherin affects epithelial morphogenesis and invasion, but not transformation

Journal of Cell Science, 2001
ABSTRACT MDCK cells were engineered to reversibly express mutant E-cadherin protein with a large extracellular deletion. Mutant cadherin overexpression reduced the expression of endogenous E-and K-cadherins in MDCK cells to negligible levels, resulting in decreased cell adhesion. Despite severe impairment of the cadherin adhesion system,
M L, Troxell, D J, Loftus, W J, Nelson, J A, Marrs   +3 more
openaire   +2 more sources

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

Nature Cell Biology, 2000
E. Batlle, E. Sancho, C. Francı́, David Domı́nguez, M. Monfar, J. Baulida, A. G. Herreros   +6 more
semanticscholar   +1 more source

Cadherin-dependent organization and disorganization of epithelial architecture.

Princess Takamatsu symposia, 1997
Epithelial cell layers exhibit an ordered polarized architecture. However, such structures are disrupted during malignant transformation, which generally coincides with a loss of regulate cell growth. We are investigating how the cadherin cell adhesion system controls these processes.
M, Takeichi, M, Watabe, S, Shibamoto, F, Ito   +3 more
openaire   +1 more source

Rare Variants in the Epithelial Cadherin Gene Underlying the Genetic Etiology of Nonsyndromic Cleft Lip with or without Cleft Palate

Human Mutation, 2015
L. Brito, G. Yamamoto, Soraia Melo, Carolina Malcher, S. G. Ferreira, J. Figueiredo, L. Alvizi, G. Kobayashi, M. Naslavsky, N. Alonso, T. Félix, M. Zatz, R. Seruca, M. Passos-Bueno   +13 more
semanticscholar   +1 more source