Identification of a novel human E-Cadherin splice variant andassessment of its effects upon EMT-related events [PDF]
, 2018 Epithelial Cadherin (E-cadherin) is involved in calcium-dependent cell-cell adhesion and signal transduction. The E-cadherin decrease/loss is a hallmark of Epithelial to Mesenchymal Transition (EMT), a key event in tumor progression.
Besso, María José +8 more
core +1 more source
So far, yet so close: α-Catenin dimers help migrating cells get together [PDF]
, 2017 Epithelial cells in tissues use their actin cytoskeletons to stick together, whereas unattached cells make active plasma membrane protrusions to migrate. In this issue, Wood et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201612006) show that the
Benjamin +12 more
core +2 more sources
SCD5 restored expression favors differentiation and epithelial-mesenchymal reversion in advanced melanoma [PDF]
, 2018 Our previous data supported a role for the Stearoyl-CoA desaturase (SCD5) in protection against malignancy, whereby it appears to functionally modify tumor stroma impairing tumor spread.
Bellenghi, Maria +8 more
core +1 more source
Regulation of cadherin-based epithelial cell adhesion by endocytosis [PDF]
Frontiers in Bioscience, 2009 Regulation of cadherin-based adhesion is an important but poorly studied question. Little is known which mechanisms control the size, number, strength, dynamics, and motility of adherens junctions. Cadherin endocytosis has been suggested to be one such mechanism.
openaire +2 more sources
SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium. [PDF]
PLoS ONE, 2014 Expression of the cellular adhesion protein N-cadherin is a critical event during epithelial-mesenchymal transition (EMT). The SMAD4 protein has been identified as a mediator of transforming growth factor-β (TGF-β) superfamily signaling, which regulates ...
Ya'an Kang +11 more
doaj +1 more source
Actin at cell-cell junctions is composed of two dynamic and functional populations [PDF]
, 2005 The ability of epithelial cells to polarize requires cell-cell adhesion mediated by cadherin receptors. During cell-cell contact, the mechanism via which a flat, spread cell shape is changed into a tall, cuboidal epithelial morphology is not known.
Bailly, M. +6 more
core +1 more source
E-cadherin bridges cell polarity and spindle orientation to ensure prostate epithelial integrity and prevent carcinogenesis in vivo. [PDF]
PLoS Genetics, 2018 Cell polarity and correct mitotic spindle positioning are essential for the maintenance of a proper prostate epithelial architecture, and disruption of the two biological features occurs at early stages in prostate tumorigenesis. However, whether and how
Xue Wang +11 more
doaj +1 more source
Impact of chronic exposure to bevacizumab on EpCAM-based detection of circulating tumor cells [PDF]
, 2015 BACKGROUND: Circulating tumor cells (CTCs) are often undetected through the immunomagnetic epithelial cell adhesion molecule (EpCAM)-based CellSearch(®) System in breast and colorectal cancer (CRC) patients treated with bevacizumab (BEV), where low ...
GAZZANIGA, PAOLA +7 more
core +1 more source
Epithelial cadherin distribution in abnormal human pre-implantation embryos [PDF]
Human Reproduction, 2005 E(epithelial)-cadherin is a vital cell adhesion protein that plays a critical role in morphogenesis. Previous studies of E-cadherin distribution in human embryos have produced equivocal results.Immunocytochemistry in conjunction with laser scanning confocal microscopy was used to detect E-cadherin in 97 human cleavage stage embryos and 35 blastocysts ...
openaire +2 more sources
Journal of Circulating Biomarkers, 2018 Epithelial cell adhesion molecule (EpCAM)-targeted capture remains the most common isolation strategy for circulating tumor cells (CTCs). However, epithelial-to-mesenchymal transition (EMT) leads to decreased epithelial EpCAM expression affecting the ...
Joseph W Po +8 more
doaj +1 more source