Results 131 to 140 of about 71,499 (299)

Annexin II Light Chain p11 Interacts With ENaC to Increase Functional Activity at the Membrane

Frontiers in Physiology, 2019
The epithelial Na+ channel (ENaC) provides for Na+ absorption in various types of epithelia including the kidney, lung, and colon where ENaC is localized to the apical membrane to enable Na+ entry into the cell.
Tanya T. Cheung, Noor A. S. Ismail, Noor A. S. Ismail, Rachel Moir, Nikhil Arora, Fiona J. McDonald, Steven B. Condliffe   +6 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Salt Intake, Salt Sensitivity and Hypertension in Nigerians: An Overview

The Proceedings of the Nigerian Academy of Science, 2013
It is widely recognized that a high dietary intake of salt can result in hypertension and various studies have confirmed this link. Epidemiological studies have shown that communities that consume large amounts of salt in their diet have a high incidence
Soga Sofola FAS, S. O. Elias, E. A. Azinge, A. K. Oloyo   +3 more
doaj   +1 more source

Structural characterization of δβγ epithelial sodium channels provide insight into channel assembly [PDF]

When thinking of sodium channels in the nervous system the most notable are voltage gated sodium channels, but a multitude of non-voltage gated channels also contribute to sodium homeostasis in the brain.
Houser, Alexandra
core   +1 more source

A long isoform of the epithelial sodium channel alpha subunit forms a highly active channel [PDF]

, 2015
A long isoform of the human Epithelial Sodium Channel (ENaC) α subunit has been identified, but little data exist regarding the properties or regulation of channels formed by α728. The baseline whole cell conductance of oocytes expressing trimeric α728βγ
Jonathan M Berman (688664), Mouhamed S Awayda (688665), Cristin Brand (675880)   +2 more
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Heterologous expression of a mammalian epithelial sodium channel in yeast [PDF]

, 2000
The α and β subunits of the amiloride-sensitive rat epithelial sodium channel (αβENaC) were expressed in the yeast Saccharomyces cerevisiae. We used a combination of yeast strains, including a mutant in the secretory pathway (sec6), and Western blotting ...
Gupta, Soma Sen, Canessa, Cecilia M, Cecilia M Canessa, Soma Sen Gupta   +3 more
core   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Proteolytic Activation of the Epithelial Sodium Channel (ENaC): Its Mechanisms and Implications. [PDF]

Int J Mol Sci, 2023
Aufy M, Hussein AM, Stojanovic T, Studenik CR, Kotob MH.   +4 more
europepmc   +1 more source