Results 31 to 40 of about 212,176 (344)

Regulation of Epithelial Sodium Transport via Epithelial Na⁺ Channel [PDF]

BioMed Research International, 2011
Renal epithelial Na+ transport plays an important role in homeostasis of our body fluid content and blood pressure. Further, the Na+ transport in alveolar epithelial cells essentially controls the amount of alveolar fluid that should be kept at an appropriate level for normal gas exchange.
Marunaka, Yoshinori, Niisato, Naomi, Taruno, Akiyuki, Ohta, Mariko, Miyazaki, Hiroaki, Hosogi, Shigekuni, Nakajima, Ken-ichi, Kusuzaki, Katsuyuki, Ashihara, Eishi, Nishio, Kyosuke, Iwasaki, Yoshinobu, Nakahari, Takashi, Kubota, Takahiro   +12 more
openaire   +2 more sources

High glucose up-regulates ENaC and SGK1 expression in HCD-cells [PDF]

, 2006
Background/Aim: Diabetic nephropathy is associated with progressive renal damage, leading to impaired function and end-stage renal failure. Secondary hypertension stems from a deranged ability of cells within the kidney to resolve and appropriately ...
Bell LM, Bhargava A, Bland R, Christensen O, Claire Hills, Demerdash TM, Di Paolo S, Hoffman BB, Hong-Long JI, Jeanette Bennett, Khan ZA, Lang F, Lee CT, Lindschau C, Loffing J, Marshall SM, Paul Squires, Pierre Ronco, Prie D, Ricci C, Rosemary Bland, Rossier, Satlin LM, Sharma K, Symonian M, Urbach V, Waldegger S, Wang J, Weigert C, Whiteside CI, Yung S   +30 more
core   +1 more source

Emerging key roles for P2X receptors in the kidney [PDF]

, 2013
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E., Peppiatt-Wildman, Claire M., Schwiebert, E. M., Wildman, Scott S.P.   +3 more
core   +2 more sources

Could a defective epithelial sodium channel lead to bronchiectasis

Respiratory Research, 2008
Background Bronchiectasis is defined as a permanent dilation of the airways arising from chronic bronchial inflammation/infection. In 50% of cases, no etiology can be identified.
Hubert Dominique, Sublemontier Sébastien, Viel Marion, Fajac Isabelle, Bienvenu Thierry   +4 more
doaj   +1 more source

The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]

, 2013
Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Birch, Rebecca E, Craigie, Eilidh, Unwin, Robert J, Wildman, Scott S.P.   +3 more
core   +3 more sources

The Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis

Biomedicines, 2022
The with-no-lysine (WNK) kinase family, comprising four serine-threonine protein kinases (WNK1-4), were first linked to hypertension due to their mutations in association with pseudohypoaldosteronism type II (PHAII).
Shiuan-Chen Lin, Chun Ma, Kao-Jung Chang, Han-Ping Cheong, Ming-Cheng Lee, Yuan-Tzu Lan, Chien-Ying Wang, Shih-Hwa Chiou, Teh-Ia Huo, Tsui-Kang Hsu, Ping-Hsing Tsai, Yi-Ping Yang   +11 more
doaj   +1 more source

Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]

, 2000
Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core   +1 more source

Cell‐Specific Actions of the Prostaglandin E‐Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A beneficial role for prostanoids in hypertension is suggested by clinical studies showing nonsteroidal anti‐inflammatory drugs, which block the production of all prostanoids, cause sodium retention and exacerbate hypertension.
Ting Yang, Chengcheng Song, Donna L. Ralph, Portia Andrews, Matthew A. Sparks, Beverly H. Koller, Alicia A. McDonough, Thomas M. Coffman   +7 more
doaj   +1 more source

Functional expression of TRPV4 channels in human collecting duct cells: implications for secondary hypertension in diabetic nephropathy [PDF]

, 2012
Background. The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress.
Bland, Rosemary, Hills, Claire E., Squires, Paul E.   +2 more
core   +3 more sources

Mechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na+ channel

Scientific Reports, 2021
Activity of the Epithelial Na+ Channel (ENaC) in the distal nephron fine-tunes renal sodium excretion. Appropriate sodium excretion is a key factor in the regulation of blood pressure.
Tarek Mohamed Abd El-Aziz, Antonio G. Soares, Elena Mironova, Nina Boiko, Amanpreet Kaur, Crystal R. Archer, James D. Stockand, Jonathan M. Berman   +7 more
doaj   +1 more source