Results 201 to 210 of about 472,049 (341)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

O-Linked N-Acetylglucosamine Epitope H Expression in Placentas of Pregnancies Complicated With Fetal Growth Restriction: A Case-Control Immunochemistry Study. [PDF]

In Vivo
Karkabouna A, Samara AA, Zacharouli K, Ioannou M, Garas A, Daponte A, Sotiriou S.   +6 more
europepmc   +1 more source

Epitope mapping of function‐blocking monoclonal antibody CM6 suggests a “weak” integrin binding site on the laminin‐332 LG2 domain [PDF]

, 2010
Hironobu Yamashita, Meiling Shang, Manisha Tripathi, Jérôme Jourquin, Walter Georgescu, Shanshan Liu, Brandy Weidow, Vito Quaranta   +7 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Design of a novel multi epitope antigen for diagnosis of visceral leishmaniasis using an immunoinformatics approach. [PDF]

Sci Rep
Baneshi M, Sadeghi M, Hashemi S, Alcedo C, Muro A, Manzano-Román R, Savardashtaki A, Rashidi S.   +7 more
europepmc   +1 more source

Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus [PDF]

, 2009
Di Wu, Tianlei Xu, Jing Sun, Jianxin Dai, Guohui Ding, Yungang He, Zhengfeng Zhou, Hui Xiong, Hui Dong, Weirong Jin, Chao Bian, Jin Li, Hongyan Wang, Xiaoning Wang, Zhong Yang, Zhong Yang, Hao Wang, Xiaoyan Che, Zhong Huang, Ke Lan, Bing Sun, Fan Wu, ZhenAn Yuan, Xi Zhang, Xiao‐Nong Zhou, Jiahai Zhou, Zhiyong Ma, Guangzhi Tong, Yajun Guo, Guoping Zhao, Yixue Li, Zhiwei Cao   +31 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Identification of a Linear B-Cell Epitope in the African Swine Fever Virus pE248R Protein Targeted by Monoclonal Antibodies. [PDF]

Microorganisms
Liu E, Liu X, Chen Y, Liu H, Zhou J, Wang A.   +5 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Reproducible Sequence-Level Strategy to Enhance Peptide Immunogenicity While Preserving Wild-Type Epitope Recognition. [PDF]

Antibodies (Basel)
Chen CH, Chiu YC, Huang KY, Huang HH, Kuo TW, Liu YC, Kao HJ, Yu CL, Weng SL, Liao KW.   +9 more
europepmc   +1 more source