Results 81 to 90 of about 12,449,745 (282)

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

The role of mutations in core protein of hepatitis B virus in liver fibrosis

Virology Journal, 2009
The core protein of hepatitis B virus encompasses B- and T-cell immunodominant epitopes and subdivided into two domains: the N-terminal and the functional C-terminal consisted phosphorylation sites.
Abbasi Shahsanam, Nouraein Omidreza, Poustchi Hossein, Jazii Ferdous, Mohamadkhani Ashraf, Sotoudeh Masoud, Montazeri Ghodratollah   +6 more
doaj   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Peptide vaccine against chikungunya virus: immuno-informatics combined with molecular docking approach

Journal of Translational Medicine, 2018
Background Chikungunya virus (CHIKV), causes massive outbreaks of chikungunya infection in several regions of Asia, Africa and Central/South America. Being positive sense RNA virus, CHIKV replication within the host resulting in its genome mutation and ...
Muhammad Tahir ul Qamar, Amna Bari, Muhammad Muzammal Adeel, Arooma Maryam, Usman Ali Ashfaq, Xiaoyong Du, Iqra Muneer, Hafiz Ishfaq Ahmad, Jia Wang   +8 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Immunoinformatics-Based Design of Multi-epitope DNA and mRNA Vaccines Against Zika Virus

Bioinformatics and Biology Insights
In this study, we used an immunoinformatics approach to predict antigenic epitopes of Zika virus (ZIKV) proteins to assist in designing a vaccine antigen against ZIKV. We performed the prediction of CD8+ T-lymphocyte and antigenic B-cell epitopes of ZIKV
Juciene de Matos Braz, Marcus Vinicius de Aragão Batista   +1 more
doaj   +1 more source

Clinical Serum-Anchored Computational Design Pipeline for a Broad-Spectrum Influenza Multi-Epitope mRNA Vaccine

Biology
Influenza’s pandemic threat is driven by antigenic drift, which limits the efficacy of conventional vaccines. To address this challenge, we established a clinical serum-anchored computational design pipeline for a broad-spectrum multi-epitope mRNA ...
Lifang Yuan, Zhiyao Ouyang, Yifan Zhao, Rongjun Bi, Yanjing Wu, Xu Li, Yingrui Li, Jiaping Song, Wei Li, Mingchen Yan, Simin Wen, Huanle Luo, Tian Bai, Yuelong Shu, Yongkun Chen   +14 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Design of A Multi-epitope Vaccine Candidate against Q Fever based on the Outer Mem-brane Proteins OMP1 and LolB: An Immunoinformatic Study [PDF]

Iranian South Medical Journal
Background: Q fever—caused by Coxiella burnetii—is a zoonotic disease reported worldwide. It can cause severe complications in the host, manifesting with conditions such as liver, heart, and vascular failure, pneumonia, and long-term chronic fatigue ...
Hamid Vaez, Ladan Shahrakimojahed
doaj  

Immunoinformatics-Guided Identification and Functional Screening of T Cell Epitopes from Mycobacterium tuberculosis for Multi-Epitope mRNA Vaccine Design

Biologics
Background/Objectives: Tuberculosis, caused by Mycobacterium tuberculosis, remains a major global health challenge requiring novel prevention strategies.
Zibei Huang, Beibei Wu, Zhengwei Liu, Zhangnv Yang, Shigui Yang, Jianmin Jiang   +5 more
doaj   +1 more source