Results 91 to 100 of about 395,501 (352)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins [PDF]

Virology Journal, 2012
Abstract Background Ebola viruses (EBOVs) cause severe hemorrhagic fever with a high mortality rate. At present, there are no licensed vaccines or efficient therapies to combat EBOV infection. Previous studies have shown that both humoral and cellular immune responses are crucial for controlling Ebola infection.
Shaoqiong Yi, Song Xiaohong, Ting Yu, Shipo Wu, Lihua Hou, Wei Chen   +5 more
openaire   +4 more sources

Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes.

PLoS Pathogens, 2012
We quantified CD8 T cells needed to cause type 1 diabetes and studied the anatomy of the CD8 T cell/beta (β) cell interaction at the immunologic synapse.
Michael B A Oldstone, Kurt H Edelmann, Dorian B McGavern, Justin T Cruite, Megan J Welch   +4 more
doaj   +1 more source

Generation of Immortalized Murine Cell Lines with SV 40 T Antigen Derivatives Bearing Alterations in a Novel MHC Class II-Restricted Epitope [PDF]

, 2008
The SV40 virus encodes an oncogenic large T antigen (T ag) protein that induces a strong immune response in mice. Four class I epitopes, I, 11/111, IV, and V have been identified within the Tag, and epitope V has been shown to be immunorecessive.
Peters, Andrea J.
core   +1 more source

Results of a randomized, double-blind phase II clinical trial of NY-ESO-1 vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in participants with high-risk resected melanoma. [PDF]

, 2020
BACKGROUND: To compare the clinical efficacy of New York Esophageal squamous cell carcinoma-1 (NY-ESO-1) vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in a randomized, double-blind phase II study in participants with fully resected melanoma at
Behren, A, Brimble, M, Cebon, JS, Cerundolo, V, Chen, W, Corrie, PG, Dalgleish, AG, Davis, ID, Dunbar, PR, Endo-Munoz, L, Evans, TRJ, Findlay, MPN, Fisher, C, Gore, M, Haack, D, Hersey, P, Jackson, HM, MacGregor, D, Maraskovsky, E, Maria, M, Marsden, J, McArthur, GA, Millward, M, Nathan, P, Old, LJ, Ottensmeier, CH, Smithers, M, Thompson, JF, Tutuka, CSA, Venhaus, R, Walpole, E, Williams, G, Winkler, S   +32 more
core   +4 more sources

Identification of two cytotoxic T lymphocyte-recognized epitopes in the Ras protein. [PDF]

The Journal of experimental medicine, 1993
We have investigated the possibility of inducing cytotoxic T lymphocytes (CTL) to Ras containing a mutation at position 61 or to normal Ras, using recombinant vaccinia viruses expressing these proteins. CTL from C57Bl/10 mice immunized with vaccinia expressing mutant Ras showed specificity for the mutant Ras protein and recognition of normal Ras was ...
Jonathan Skipper, Hans J. Stauss
openaire   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Cytotoxic T Lymphocyte Epitopes of HIV-1 Nef

Journal of Experimental Medicine, 2000
Although a pivotal role of proteasomes in the proteolytic generation of epitopes for major histocompatibility complex (MHC) class I presentation is undisputed, their precise function is currently the subject of an active debate: do proteasomes generate ...
Maria Lucchiari-Hartz, Peter M. van Endert, G. Lauvau, R. Maier, A. Meyerhans, D. Mann, K. Eichmann, G. Niedermann   +7 more
semanticscholar   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Developing a multi-epitope vaccine candidate to combat porcine epidemic diarrhea virus and porcine deltacoronavirus co-infection by employing an immunoinformatics approach

Frontiers in Microbiology, 2023
Coinfection of porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV) is common in pig farms, but there is currently no effective vaccine to prevent this co-infection.
Wei Hou, Heqiong Wu, Wenting Wang, Ruolan Wang, Wang Han, Sibei Wang, Bin Wang, Bin Wang, Haidong Wang   +8 more
doaj   +1 more source