Results 71 to 80 of about 395,501 (352)

Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection.

Journal of Clinical Investigation, 1995
It has been suggested that immune selection pressure exerted by the cytotoxic T lymphocyte (CTL) response could be responsible for viral persistence during chronic hepatitis B virus infection.
Barbara Rehermann, C. Pasquinelli, S. Mosier, F. Chisari   +3 more
semanticscholar   +1 more source

Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes. [PDF]

, 2003
CD8+ class I-restricted cytotoxic T lymphocytes (CTLs) usually incompletely suppress HIV-1 in vivo, and while analogous partial suppression induces antiretroviral drug-resistance mutations, epitope escape mutations are inconsistently observed.
Ali, Ayub, Brander, Christian, Harlow, Jason D, Kalams, Spyros A, Sarkis, Phuong Thi Nguyen, Walker, Bruce D, Yang, Otto O   +6 more
core  

Evaluating frequency and quality of pathogen-specific T cells. [PDF]

, 2016
It is generally accepted that enumeration and characterization of antigen-specific T cells provide essential information about potency of the immune response.
,, Anikeeva, Nadia, Grosso, Dolores, Sykulev, Yuri   +3 more
core   +2 more sources

B- and T-lymphocyte responses to an immunodominant epitope of human immunodeficiency virus [PDF]

Journal of Virology, 1988
Using synthetic peptides, we characterized the B-lymphocyte (antibody) and T-lymphocyte (proliferation) responses to an immunodominant epitope of human immunodeficiency virus type 1 (HIV-1) located near the amino-terminal end of the transmembrane glycoprotein (env amino acids 598 to 609).
K. Shriver, Jay A. Nelson, J. W. Gnann, R. D. Schrier, A. J. Langlois, Michael B. A. Oldstone   +5 more
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Antigen-specific T cell responses in autoimmune diabetes

Frontiers in Immunology
Autoimmune diabetes is a disease characterized by the selective destruction of insulin-secreting β-cells of the endocrine pancreas by islet-reactive T cells.
Alexander J. Dwyer, Zachary R. Shaheen, Brian T. Fife   +2 more
doaj   +1 more source

Efficient Identification of Novel Hla-A*0201–Presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen Prame by Proteasome-Mediated Digestion Analysis

Journal of Experimental Medicine, 2001
We report the efficient identification of four human histocompatibility leukocyte antigen (HLA)-A*0201–presented cytotoxic T lymphocyte (CTL) epitopes in the tumor-associated antigen PRAME using an improved “reverse immunology” strategy.
J. Kessler, N. Beekman, S. A. Bres-Vloemans, Pauline Verdijk, P. V. van Veelen, Antoinette M. Kloosterman-Joosten, D. Vissers, G. J. T. ten Bosch, M. Kester, A. Sijts, J. Drijfhout, F. Ossendorp, R. Offringa, C. Melief   +13 more
semanticscholar   +1 more source

Reconstitution of hepatitis B virus (HBV)-specific T cell responses with treatment of human immunodeficiency virus/HBV coinfection [PDF]

, 2003
Liver-related mortality is an increasing problem in human immunodeficiency virus (HIV)/hepatitis B virus (HBV)-coinfected patients receiving highly active antiretroviral therapy (HAART).
Bertoletti, A, Gilson, RJ, Lascar, RM, Lopes, AR, Maini, MK   +4 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Decrypting the structure of major histocompatibility complex class I- restricted cytotoxic T lymphocyte epitopes with complex peptide libraries

Journal of Experimental Medicine, 1995
Complex synthetic peptide libraries with defined amino acids in one or more positions of the H-2Kb-restricted cytotoxic T lymphocyte (CTL) epitopes SIINFEKL and RGYVYQGL and mixtures of 19 amino acids in the remaining positions were used to analyze the ...
Keiko Udaka, Karl-Heinz Wiesmtiller, S. Kienle, Gfinther Jung, Peter Walden   +4 more
semanticscholar   +1 more source