Results 1 to 10 of about 4,653 (185)

Epitranscriptome-wide profiling identifies RNA editing events regulated by ADAR1 that are associated with DNA repair mechanisms in human TK6 cells [PDF]

Frontiers in Genetics
IntroductionAdenosine-to-Inosine (A-to-I) editing is an endogenous RNA modification in eukaryotes, catalyzed by adenosine deaminases acting on RNA (ADARs). This modification modulates the gene expression by influencing splicing, RNA stability, and coding
Akito Yoshida, Yuqian Song, Hotaru Takaine, Sujin Song, Nonoka Konishi, Yu-Hsien Hwang-Fu, Zachary Johnson, Kiyoe Ura, Akira Sassa   +8 more
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DPred_3S: identifying dihydrouridine (D) modification on three species epitranscriptome based on multiple sequence-derived features [PDF]

Frontiers in Genetics, 2023
Introduction: Dihydrouridine (D) is a conserved modification of tRNA among all three life domains. D modification enhances the flexibility of a single nucleotide base in the spatial structure and is disease- and evolution-associated.
Jinjin Ren, Jinjin Ren, Xiaozhen Chen, Zhengqian Zhang, Haoran Shi, Shuxiang Wu, Shuxiang Wu   +6 more
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Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]

eLife, 2020
Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Matthew T Parker, Katarzyna Knop, Anna V Sherwood, Nicholas J Schurch, Katarzyna Mackinnon, Peter D Gould, Anthony JW Hall, Geoffrey J Barton, Gordon G Simpson   +8 more
doaj   +5 more sources

Antibiotic‐Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism [PDF]

Advanced Science
Gut microbiota can influence host gene expression and physiology through metabolites. Besides, the presence or absence of gut microbiome can reprogram host transcriptome and epitranscriptome as represented by N6‐methyladenosine (m6A), the most abundant ...
Meng Yang, Xiaoqi Zheng, Jiajun Fan, Wei Cheng, Tong‐Meng Yan, Yushan Lai, Nianping Zhang, Yi Lu, Jiali Qi, Zhengyi Huo, Zihe Xu, Jia Huang, Yuting Jiao, Biaodi Liu, Rui Pang, Xiang Zhong, Shi Huang, Guan‐Zheng Luo, Gina Lee, Christian Jobin, A. Murat Eren, Eugene B Chang, Hong Wei, Tao Pan, Xiaoyun Wang   +24 more
doaj   +3 more sources

Rewriting the Fate of Cancer: Epigenetic and Epitranscriptomic Regulators in the Metastatic Cascade [PDF]

Biomolecules
Metastasis is the leading cause of cancer-related mortality, representing a highly coordinated, multistep process in which malignant cells gain the ability to invade, survive in the circulation, and establish secondary tumors at distant sites.
Toshifumi Hara, Murugan Subramanian
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Statistical modeling of single-cell epitranscriptomics enabled trajectory and regulatory inference of RNA methylation [PDF]

Cell Genomics
Summary: As a fundamental mechanism for gene expression regulation, post-transcriptional RNA methylation plays versatile roles in various biological processes and disease mechanisms.
Haozhe Wang, Yue Wang, Jingxian Zhou, Bowen Song, Gang Tu, Anh Nguyen, Jionglong Su, Frans Coenen, Zhi Wei, Daniel J. Rigden, Jia Meng   +10 more
doaj   +2 more sources

Single-cell analysis of the epitranscriptome: RNA modifications under the microscope [PDF]

RNA Biology
The identification of mechanisms capable of modifying genetic information by the addition of covalent RNA modifications distinguishes a level of complexity in gene expression which challenges key long-standing concepts of RNA biology.
Eva Crespo-García, Alberto Bueno-Costa, Manel Esteller   +2 more
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Quantifying the mRNA epitranscriptome reveals epitranscriptome signatures and roles in cancer [PDF]

Cellular and Molecular Life Sciences
Post-transcriptional modifications on mRNA are crucial for mRNA fate and function. The current lack of a comprehensive method for high-coverage and sensitive quantitative analysis of mRNA modifications significantly limits the discovery of new mRNA ...
Ying Feng, Xiaoli He, Mingxin Guo, Ying Tang, Guantong Qi, Qian Huang, Wenran Ma, Hong Chen, Yifan Qin, Ruiqi Li, Jin Wang, Yu Liu   +11 more
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Interpretable deep cross networks unveiled common signatures of dysregulated epitranscriptomes across 12 cancer types [PDF]

Molecular Therapy: Nucleic Acids
Cancer is a complex and multifaceted group of diseases characterized by uncontrolled cell growth that leads to the formation of malignant tumors. Recent studies suggest that N6-methyladenosine (m6A) RNA methylation plays pivotal roles in cancer pathology
Rong Xia, Xiangyu Yin, Jiaming Huang, Kunqi Chen, Jiongming Ma, Zhen Wei, Jionglong Su, Neil Blake, Daniel J. Rigden, Jia Meng, Bowen Song   +10 more
doaj   +2 more sources

The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections

Frontiers in Genetics, 2023
Emerging evidence highlights the multifaceted roles of the RNA epitranscriptome during viral infections. By modulating the modification landscape of viral and host RNAs, viruses enhance their propagation and elude host surveillance mechanisms.
Diana Roberta Ribeiro, Alexandre Nunes, Daniela Ribeiro, Ana Raquel Soares   +3 more
doaj   +1 more source