Results 1 to 10 of about 5,392 (239)

Antibiotic‐Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism [PDF]

Advanced Science
Gut microbiota can influence host gene expression and physiology through metabolites. Besides, the presence or absence of gut microbiome can reprogram host transcriptome and epitranscriptome as represented by N6‐methyladenosine (m6A), the most abundant ...
Meng Yang, Xiaoqi Zheng, Jiajun Fan, Wei Cheng, Tong‐Meng Yan, Yushan Lai, Nianping Zhang, Yi Lu, Jiali Qi, Zhengyi Huo, Zihe Xu, Jia Huang, Yuting Jiao, Biaodi Liu, Rui Pang, Xiang Zhong, Shi Huang, Guan‐Zheng Luo, Gina Lee, Christian Jobin, A. Murat Eren, Eugene B Chang, Hong Wei, Tao Pan, Xiaoyun Wang   +24 more
doaj   +5 more sources

Epitranscriptome-wide profiling identifies RNA editing events regulated by ADAR1 that are associated with DNA repair mechanisms in human TK6 cells [PDF]

Frontiers in Genetics
IntroductionAdenosine-to-Inosine (A-to-I) editing is an endogenous RNA modification in eukaryotes, catalyzed by adenosine deaminases acting on RNA (ADARs). This modification modulates the gene expression by influencing splicing, RNA stability, and coding
Akito Yoshida, Yuqian Song, Hotaru Takaine, Sujin Song, Nonoka Konishi, Yu-Hsien Hwang-Fu, Zachary Johnson, Kiyoe Ura, Akira Sassa   +8 more
doaj   +3 more sources

Quantifying the mRNA epitranscriptome reveals epitranscriptome signatures and roles in cancer [PDF]

Cellular and Molecular Life Sciences
Post-transcriptional modifications on mRNA are crucial for mRNA fate and function. The current lack of a comprehensive method for high-coverage and sensitive quantitative analysis of mRNA modifications significantly limits the discovery of new mRNA ...
Ying Feng, Xiaoli He, Mingxin Guo, Ying Tang, Guantong Qi, Qian Huang, Wenran Ma, Hong Chen, Yifan Qin, Ruiqi Li, Jin Wang, Yu Liu   +11 more
doaj   +3 more sources

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]

eLife, 2020
Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Matthew T Parker, Katarzyna Knop, Anna V Sherwood, Nicholas J Schurch, Katarzyna Mackinnon, Peter D Gould, Anthony JW Hall, Geoffrey J Barton, Gordon G Simpson   +8 more
doaj   +5 more sources

Toward standardized epitranscriptome analytics: an inter-laboratory comparison of mass spectrometric detection and quantification of modified ribonucleosides in human RNA. [PDF]

Nucleic Acids Res
The human RNome comprises all forms of RNA and the 50 + chemical structures—the epitranscriptome—that modify them. Understanding the diverse functions of RNA modifications in regulating gene expression and cell phenotype requires technologies such as RNA
Hengesbach M, Chan CK, Bhandari T, Bruzel A, DeMott MS, Podoprygorina G, Sun G, Tabeling E, Cheung VG, Dedon PC, Helm M, Limbach PA.   +11 more
europepmc   +2 more sources

CompasSeq: epitranscriptome-wide percentage assessment of metabolite-capped RNA at the transcript resolution. [PDF]

Nat Commun
Nucleotide-containing metabolites, e.g., NAD, can serve as noncanonical initiating nucleotides (NCIN) during transcription, yielding NCIN-capped RNAs (NCIN-RNAs).
Liu Y, Li D, Wang X, Niu K, Bai J, Qu L, Liu N.   +6 more
europepmc   +2 more sources

Exploring the methyl-verse: Dynamic interplay of epigenome and m6A epitranscriptome. [PDF]

Mol Ther
The orchestration of dynamic epigenetic and epitranscriptomic modifications is pivotal for the fine-tuning of gene expression. However, they are traditionally being examined independently.
Pilala KM, Panoutsopoulou K, Papadimitriou MA, Soureas K, Scorilas A, Avgeris M.   +5 more
europepmc   +2 more sources

Statistical modeling of immunoprecipitation efficiency of MeRIP-seq data enabled accurate detection and quantification of epitranscriptome. [PDF]

Comput Struct Biotechnol J
Background Recent advancements in epitranscriptomics highlight reversible RNA modifications as crucial regulators, with N6-methyladenosine (m6A) being abundant in eukaryotic mRNAs.
Wang H, Chen K, Wei Z, Song B, Zhu M, Su J, Nguyen A, Meng J, Wang Y.   +8 more
europepmc   +2 more sources

Rewriting the Fate of Cancer: Epigenetic and Epitranscriptomic Regulators in the Metastatic Cascade [PDF]

Biomolecules
Metastasis is the leading cause of cancer-related mortality, representing a highly coordinated, multistep process in which malignant cells gain the ability to invade, survive in the circulation, and establish secondary tumors at distant sites.
Toshifumi Hara, Murugan Subramanian
doaj   +2 more sources

Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing. [PDF]

Nat Commun
RNA polymerase III (Pol III) transcribes cytosolic transfer RNAs (tRNAs) and other non-coding RNAs (ncRNAs) essential to cellular function. However, many aspects of Pol III transcription and processing, including RNA modifications, remain poorly ...
Verstraten R, Cetraro P, Fitzpatrick AH, Alwie Y, Frommeyer YN, Loliashvili E, Stein SC, Häussler S, Ouwendijk WJD, Depledge DP.   +9 more
europepmc   +2 more sources