Results 111 to 120 of about 5,392 (239)

Writers, readers and erasers of RNA modifications in cancer [PDF]

, 2020
Although cancer was originally considered a disease driven only by genetic mutations, it has now been proven that it is also an epigenetic disease driven by DNA hypermethylation-associated silencing of tumor suppressor genes and aberrant histone ...
Bueno-Costa, Alberto, Esteller, M., Esteve-Puig, R., Universitat Autònoma de Barcelona   +3 more
core   +1 more source

Modifying gene expression through passive forces

eLife
The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.
Sarah Hallstein, Julian König
doaj   +1 more source

PATTERNA: transcriptome-wide search for functional RNA elements via structural data signatures. [PDF]

, 2018
Establishing a link between RNA structure and function remains a great challenge in RNA biology. The emergence of high-throughput structure profiling experiments is revolutionizing our ability to decipher structure, yet principled approaches for ...
Aviran, Sharon, Ledda, Mirko
core  

Comprehensive Genome‐Wide Identification and Expression Analysis of the N6‐Methyladenosine (m6A) Regulatory Network Influences Rapid Stress Adaptation With Exogenous Melatonin in Rice

Journal of Pineal Research, Volume 78, Issue 1, January 2026.
ABSTRACT Exogenous melatonin has emerged as a pivotal multifunctional signaling molecule, recognized for its critical role in enhancing stress tolerance and improving crop productivity. N6‐methyladenosine (m6A) is the most prevalent internal modification found in eukaryotic mRNA and plays a crucial role in regulating plant growth, development, and ...
Hira Khanzada, Ghulam Mustafa Wassan, Ping Wang, Saba Khanzada, Xiaoning Wang, Zhihui Xia   +5 more
wiley   +1 more source

Plant ribosomes as a score to fathom the melody of 2’-O-methylation across evolution

RNA Biology
2’-O-ribose methylation (2’-O-Me) is one of the most common RNA modifications detected in ribosomal RNAs (rRNA) from bacteria to eukaryotic cells. 2’-O-Me favours a specific RNA conformation and protects RNA from hydrolysis.
Sara Alina Neumann, Christine Gaspin, Julio Sáez-Vásquez   +2 more
doaj   +1 more source

An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization

Cells, 2019
Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast, Paul H.A. Quax, A. Yaël Nossent   +2 more
doaj   +1 more source

Epitranscriptomic code and its alterations in human disease [PDF]

, 2018
Innovations in epitranscriptomics have resulted in the identification of more than 160 RNA modifications to date. These developments, together with the recent discovery of writers, readers, and erasers of modifications occurring across a wide range of ...
Janga, Sarath Chandra, Kadumuri, Rajashekar Varma   +1 more
core   +1 more source

Epitranscriptomics: Mapping Methods and Beyond [PDF]

BioTechniques, 2018
The field of epigenetics has changed the way we look at both DNA and proteins. Could the same be true for RNA? Joseph Martin discusses. [Graphic: see text]
openaire   +2 more sources

The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial

Frontiers in Immunology
BackgroundEpitranscriptomics, with m6A as the most prevalent in mammals, is a novel treatment target for inflammatory diseases, including cardiovascular diseases.
Tuva B. Dahl, Tuva B. Dahl, Ana Quiles-Jiménez, Kaspar Broch, Kaspar Broch, Anne Kristine Anstensrud, Anne Kristine Anstensrud, Lars Gullestad, Lars Gullestad, Lars Gullestad, Geir Ø. Andersen, Geir Ø. Andersen, Ola Kleveland, Jonas Øgaard, Jonas Øgaard, Vigdis Bjerkeli, Vigdis Bjerkeli, Azita Rashidi, Kuan Yang, Kirsten B. Holven, Kirsten B. Holven, Pål Aukrust, Magnar Bjørås, Magnar Bjørås, Camilla Huse, Camilla Huse, Camilla Huse, Bente Halvorsen, Bente Halvorsen   +28 more
doaj   +1 more source

The m6A Demethylase Fto Enhances Susceptibility to Atrial Fibrillation by Demethylating Kcne1 in Aging Mice

Aging Cell, Volume 24, Issue 12, December 2025.
Aging‐induced accumulation of PGE2 in cardiomyocytes blocks the degradation of Fto. Elevation of Fto in the atria represses m6A methylation of Kcnel which, in turn, leads to the reduction of Kcnel mRNA and protein. Reduced Kcnel enhances IKs currents and thereby shortens APD in atrial cardiomyocytes and increases AF inducibility.
Ruopeng Tan, Yuanjun Sun, Mengyang Yuan, Lin Wang, Xinyu Yang, Genlong Xue, Guiwen Xu, Yang Liu, Xiaomeng Yin   +8 more
wiley   +1 more source