Results 11 to 20 of about 5,392 (239)

Epitranscriptomics as a Candidate Universal Modulator of Dormancy Transitions. [PDF]

Ecol Evol
Dormancy is presented as a conserved, reversible survival program in which epitranscriptomic RNA modifications are proposed to provide a rapid, energy‐efficient layer that establishes, maintains, and terminates the state by modulating mRNA stability, translation, and localization.
Pashay Ahi E.
europepmc   +2 more sources

Statistical modeling of single-cell epitranscriptomics enabled trajectory and regulatory inference of RNA methylation [PDF]

Cell Genomics
Summary: As a fundamental mechanism for gene expression regulation, post-transcriptional RNA methylation plays versatile roles in various biological processes and disease mechanisms.
Haozhe Wang, Yue Wang, Jingxian Zhou, Bowen Song, Gang Tu, Anh Nguyen, Jionglong Su, Frans Coenen, Zhi Wei, Daniel J. Rigden, Jia Meng   +10 more
doaj   +2 more sources

Role of the epitranscriptome in viral infections: beneficial or detrimental? [PDF]

Mem Inst Oswaldo Cruz
Epitranscriptomics, the study of post-transcriptional chemical base modifications of RNAs, has become a crucial area of research for understanding the complex interactions between viruses and their hosts. These RNA modifications significantly impact both
Abdullah MF, Yee KS, Zainal N, AbuBakar S, Ling CK.   +4 more
europepmc   +2 more sources

Rewriting the RNA code: an m6a-centric framework to classify tumors and guide combination therapies [PDF]

Frontiers in Immunology
BackgroundThe epitranscriptome, particularly N6-methyladenosine (m6A), represents a dynamic layer of post-transcriptional regulation fundamentally implicated in cancer.
Yi Sun, Jinliang Wu, Guanhao Chen, Haojun Ma, Wenshuya Li, Hongyu Tan, Kerong Yang   +6 more
doaj   +2 more sources

Interpretable deep cross networks unveiled common signatures of dysregulated epitranscriptomes across 12 cancer types [PDF]

Molecular Therapy: Nucleic Acids
Cancer is a complex and multifaceted group of diseases characterized by uncontrolled cell growth that leads to the formation of malignant tumors. Recent studies suggest that N6-methyladenosine (m6A) RNA methylation plays pivotal roles in cancer pathology
Rong Xia, Xiangyu Yin, Jiaming Huang, Kunqi Chen, Jiongming Ma, Zhen Wei, Jionglong Su, Neil Blake, Daniel J. Rigden, Jia Meng, Bowen Song   +10 more
doaj   +2 more sources

Pseudouridine reprogramming in the human T-cell epitranscriptome: from primary to immortalized states. [PDF]

RNA
Immortalized cell lines are commonly used as proxies for primary cells in human biology research. For example, Jurkat leukemic T cells fundamentally contributed to uncovering T-cell signaling, activation, and immune responses.
Fanari O, Bloch D, Qiu Y, Meseonznik M, Boyko D, Makhamreh A, Wanunu M, Rouhanifard SH.   +7 more
europepmc   +2 more sources

Uncovering the Epitranscriptome: A Review on mRNA Modifications and Emerging Frontiers. [PDF]

Genes (Basel)
Background/Objectives: Messenger RNA (mRNA) modifications regulate key steps in gene expression, including splicing, translation, and stability. Despite over 300 known RNA modifications, the relatively small subset occurring in mRNA remains understudied ...
Ruden DM.
europepmc   +2 more sources

Genetic variants reshape the m⁶A epitranscriptome and drive transcriptomic reprogramming in colorectal cancer. [PDF]

Sci Rep
Genome-wide association studies (GWAS) have identified numerous single-nucleotide polymorphisms (SNPs) associated with various diseases, including cancer.
Han SH, Jang S, Kim Y, Tan K, Wilkinson MF, Jeong H, Choe J.   +6 more
europepmc   +2 more sources

Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing. [PDF]

Adv Genet (Hoboken)
This review examines recent advances in Oxford Nanopore Technologies direct RNA sequencing, highlighting its expanding capacity to detect RNA modifications beyond m6A. It discusses computational frameworks and basecalling innovations that enable single‐nucleotide and single‐molecule resolution, explores co‐occurring modifications and their regulatory ...
Liu Y, Li Y, Sun Q.
europepmc   +2 more sources

Single-cell analysis of the epitranscriptome: RNA modifications under the microscope

RNA Biology
The identification of mechanisms capable of modifying genetic information by the addition of covalent RNA modifications distinguishes a level of complexity in gene expression which challenges key long-standing concepts of RNA biology.
Eva Crespo-García, Alberto Bueno-Costa, Manel Esteller   +2 more
doaj   +2 more sources