Results 11 to 20 of about 4,711 (242)
The epitranscriptome toolbox [PDF]
Cell, 2022 In the last decade, the notion that mRNA modifications are involved in regulation of gene expression was demonstrated in thousands of studies. To date, new technologies and methods allow accurate identification, transcriptome-wide mapping, and functional characterization of a growing number of RNA modifications, providing important insights into the ...
Moshitch-Moshkovitz, Sharon +2 more
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Environmental epitranscriptomics [PDF]
Environmental Research, 2020 Chemical modifications of RNA molecules have gained increasing attention since evidence emerged for their substantive roles in a range of biological processes, such as the stability and translation of mRNA transcripts. More than 150 modifications have been identified in different organisms to date, collectively known as the 'epitranscriptome', with 6 ...
Cayir, Akin +2 more
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Spliceosomal snRNA Epitranscriptomics [PDF]
Frontiers in Genetics, 2021 Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell nucleus. snRNPs participate in pre-mRNA splicing by recognizing the critical sequence elements present
Pedro Morais, Hironori Adachi, Yi-Tao Yu
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Epitranscriptomic profile of Lactobacillus agilis and its adaptation to growth on inulin
BMC Research Notes, 2021 Objective Ribonucleic acids (RNA) are involved in many cellular functions. In general, RNA is made up by only four different ribonucleotides. The modifications of RNA (epitranscriptome) can greatly enhance the structural diversity of RNA, which in turn ...
Hongzhou Wang +6 more
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Recent advances in the plant epitranscriptome
Genome Biology, 2023 Chemical modifications of RNAs, known as the epitranscriptome, are emerging as widespread regulatory mechanisms underlying gene regulation. The field of epitranscriptomics advances recently due to improved transcriptome-wide sequencing strategies for ...
Lisha Shen +4 more
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Viral Epitranscriptomics [PDF]
Journal of Virology, 2017 ABSTRACT Although it has been known for over 40 years that eukaryotic mRNAs bear internal base modifications, it is only in the last 5 years that the importance of these modifications has begun to come into focus. The most common mRNA modification, the addition of a methyl group to the N 6 ...
Edward M, Kennedy +3 more
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Frontiers in Plant Science, 2022 Epitranscriptome constitutes a gene expression checkpoint in all living organisms. Nitrogen is an essential element for plant growth and development that influences gene expression at different levels such as epigenome, transcriptome, proteome, and ...
Francisco Ortigosa +6 more
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Refined RIP-seq protocol for epitranscriptome analysis with low input materials. [PDF]
PLoS Biology, 2018 N6-Methyladenosine (m6A) accounts for approximately 0.2% to 0.6% of all adenosine in mammalian mRNA, representing the most abundant internal mRNA modifications.
Yong Zeng +11 more
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Translating the epitranscriptome [PDF]
WIREs RNA, 2016 RNAmodifications are indispensable for the translation machinery to provide accurate and efficient protein synthesis. Whereas the importance of transfer RNA (tRNA) and ribosomal RNA (rRNA) modifications has been well described and is unquestioned for decades, the significance of internal messenger RNA (mRNA) modifications has only recently been ...
Hoernes, Thomas Philipp +1 more
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Epitranscriptomics as a Candidate Universal Modulator of Dormancy Transitions [PDF]
Ecol EvolDormancy is presented as a conserved, reversible survival program in which epitranscriptomic RNA modifications are proposed to provide a rapid, energy‐efficient layer that establishes, maintains, and terminates the state by modulating mRNA stability, translation, and localization.
Pashay Ahi E.
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