Results 51 to 60 of about 4,711 (242)
RNAEpitranscriptomics refers to chemical changes in RNAs and includes numerous chemical types with varying stoichiometry and functions. RNA modifications are highly diverse in chemistry and respond in cell-type- and cell-state-dependent manners that enable and facilitate the execution of a wide array of biological functions.
Meyer, Kate D., Pan, Tao
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Significant epitranscriptomes in heterogeneous cancer [PDF]
Cancer Science, 2019 AbstractPrecision medicine places significant emphasis on techniques for the identification of DNA mutations and gene expression by deep sequencing of gene panels to obtain medical data. However, other diverse information that is not easily readable using bioinformatics, including RNA modifications, has emerged as a novel diagnostic and innovative ...
Masamitsu Konno +2 more
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Charting new territory: The Plasmodium falciparum tRNA modification landscape
Biomedical JournalRibonucleoside modifications comprising the epitranscriptome are present in all organisms and all forms of RNA, including mRNA, rRNA and tRNA, the three major RNA components of the translational machinery.
Benjamin Sian Teck Lee +3 more
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The Role of Epitranscriptomic Modifications in the Regulation of RNA–Protein Interactions
BioChem, 2022 Epitranscriptome refers to post-transcriptional modifications to RNA and their associated regulatory factors that can govern changes in an organism’s cells in response to various environmental stimuli.
Elzbieta Wanowska +2 more
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Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA [PDF]
, 2018 The AlkB protein is a repair enzyme that uses an α-ketoglutarate/Fe(II)-dependent mechanism to repair alkyl DNA adducts. AlkB has been reported to repair highly susceptible substrates, such as 1-methyladenine and 3-methylcytosine, more efficiently in ss ...
Bian, Ke +8 more
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Frontiers in Genetics, 2021 Adenosine to inosine (A-to-I) RNA editing, the most prevalent type of RNA editing in metazoans, is carried out by adenosine deaminases (ADARs) in double-stranded RNA regions.
Dean Light +5 more
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A-to-I RNA editing in the earliest-diverging Eumetazoan phyla [PDF]
, 2017 © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology and Evolution 34 (2017): 1890-1901, doi:10.1093/molbev/msx125.The highly conserved ...
Alon, Shahar +7 more
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Charting the unknown epitranscriptome
Nature Reviews Molecular Cell Biology, 2017 RNA modifications can alter RNA structure-function relationships and various cellular processes. However, the genomic distribution and biological roles of most RNA modifications remain uncharacterized. Here, we propose using phage display antibody technology and direct sequencing through nanopores to facilitate systematic interrogation of the ...
Novoa Pardo, EM, Mason, CE, Mattick, JS
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Viruses, 2021 The TRS-mediated discontinuous transcription process is a hallmark of Arteriviruses. Precise assessment of the intricate subgenomic RNA (sg mRNA) populations is required to understand the kinetics of viral transcription.
Riteng Zhang +9 more
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RNA editing contributes to epitranscriptome diversity in chronic lymphocytic leukemia [PDF]
, 2021 RNA editing—primarily conversion of adenosine to inosine (A > I)—is a widespread posttranscriptional mechanism, mediated by Adenosine Deaminases acting on RNA (ADAR) enzymes to alter the RNA sequence of primary transcripts.
Buchumenski, Ilana +12 more
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