Results 51 to 60 of about 5,392 (239)
Molecular Oncology, 2022 N6‐methyladenosine (m6A) and its regulatory proteins have been associated with tumorigenesis in several cancer types. However, knowledge on the mechanistic network related to m6A in bladder cancer (BlCa) is rather limited, requiring further investigation
Catarina Guimarães‐Teixeira +10 more
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Dawn of Epitranscriptomic Medicine [PDF]
Circulation: Genomic and Precision Medicine, 2018 Medicine is at the crossroads of expanding disciplines. Prompt adaptation of medicine to each rapidly advancing research field, bridging bench to bedside, is a key step toward health improvement. Cardiovascular disease still ranks first among the mortality causes in the Western world, indicating a poor adaptation rate of cardiovascular medicine, albeit
Gatsiou A, Stellos K
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Internal m7G methylation: A novel epitranscriptomic contributor in brain development and diseases
Molecular Therapy: Nucleic Acids, 2023 In recent years, N7-methylguanosine (m7G) methylation, originally considered as messenger RNA (mRNA) 5′ caps modifications, has been identified at defined internal positions within multiple types of RNAs, including transfer RNAs, ribosomal RNAs, miRNA ...
Xiaohuan Xia, Yi Wang, Jialin C. Zheng
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Epitranscriptomic Reprogramming Is Required to Prevent Stress and Damage from Acetaminophen [PDF]
, 2022 Epitranscriptomic marks, in the form of enzyme catalyzed RNA modifications, play important gene regulatory roles in response to environmental and physiological conditions.
Begley, Thomas John +3 more
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Cracking the epitranscriptome [PDF]
RNA, 2016 Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made ...
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Frontiers in Genetics, 2021 Epigenetic modifications play an important role in central nervous system disorders. As a widespread posttranscriptional RNA modification, the role of the m5C modification in cerebral ischemia-reperfusion injury (IRI) remains poorly defined.
Huan Jian +31 more
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Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]
, 2016 Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
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Epitranscriptomic Regulation in Synaptic Plasticity, Aging and Neurodegeneration [PDF]
, 2022 The regulation of synaptic transmission and plasticity is essential for correct brain function, especially for learning and memory, while the weakening of synaptic transmission and loss of plasticity are hallmarks of the decline of cognitive function ...
Castro Hernández, Ricardo
core +1 more source
The mammalian mitochondrial epitranscriptome
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019 Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been emerging as an important regulatory feature of mitochondrial gene expression.
Rebelo-Guiomar, Pedro +3 more
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Progress and application of epitranscriptomic m6A modification in gastric cancer
RNA Biology, 2022 The relationship between epitranscriptomics and malignant tumours has become a popular research topic in recent years. N6-methyladenosine (m6A), the most common post-transcriptional modification in mammals, is involved in various physiological processes ...
Yitian Xu, Chen Huang
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