Results 61 to 70 of about 5,392 (239)
BMC Plant BiologyRNA m6A methylation installed by RNA methyltransferases plays a crucial role in regulating plant growth and development and environmental stress responses.
Yingbo Li +6 more
semanticscholar +1 more source
The Epitranscriptome and Innate Immunity [PDF]
PLOS Genetics, 2015 Our knowledge of the variety and abundances of RNA base modifications is rapidly increasing. Modified bases have critical roles in tRNAs, rRNAs, translation, splicing, RNA interference, and other RNA processes, and are now increasingly detected in all types of transcripts.
O'Connell, Mary +2 more
openaire +4 more sources
Biomolecules, 2023 The significance of internal mRNA modifications for the modulation of transcript stability, for regulation of nuclear export and translation efficiency, and their role in suppressing innate immunity is well documented.
Milena N. Leseva +3 more
doaj +1 more source
Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver [PDF]
, 2017 Increased oxidative stress is an unavoidable consequence of exposure to the space environment. Our previous studies showed that mice exposed to space for 13.5 days had decreased glutathione levels, suggesting impairments in oxidative defense.
Blaber, Elizabeth A. +2 more
core +3 more sources
RNAEpitranscriptomics refers to chemical changes in RNAs and includes numerous chemical types with varying stoichiometry and functions. RNA modifications are highly diverse in chemistry and respond in cell-type- and cell-state-dependent manners that enable and facilitate the execution of a wide array of biological functions.
Meyer, Kate D., Pan, Tao
openaire +2 more sources
Significant epitranscriptomes in heterogeneous cancer [PDF]
Cancer Science, 2019 AbstractPrecision medicine places significant emphasis on techniques for the identification of DNA mutations and gene expression by deep sequencing of gene panels to obtain medical data. However, other diverse information that is not easily readable using bioinformatics, including RNA modifications, has emerged as a novel diagnostic and innovative ...
Masamitsu Konno +2 more
openaire +2 more sources
Charting new territory: The Plasmodium falciparum tRNA modification landscape
Biomedical JournalRibonucleoside modifications comprising the epitranscriptome are present in all organisms and all forms of RNA, including mRNA, rRNA and tRNA, the three major RNA components of the translational machinery.
Benjamin Sian Teck Lee +3 more
doaj +1 more source
Recent Acquisition of Functional m6A RNA Demethylase Domain in Orchid Ty3/Gypsy Elements [PDF]
, 2022 [EN] Long terminal repeats (LTR) retrotransposons are transposable elements (TEs) representing major components of most plant genomes. The fixation of additional conserved protein domains in their genomes is considered a rare event in the course of their
Alvarado-Marchena, Luis +4 more
core +2 more sources
Epitranscriptomic investigation of myopia-associated RNA editing in the retina
Frontiers in Neuroscience, 2023 Myopia is one of the most common causes of vision loss globally and is significantly affected by epigenetics. Adenosine-to-inosine (A-to-I RNA) editing is an epigenetic process involved in neurological disorders, yet its role in myopia remains ...
Xu-Bin Pan +24 more
doaj +1 more source
Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA [PDF]
, 2018 The AlkB protein is a repair enzyme that uses an α-ketoglutarate/Fe(II)-dependent mechanism to repair alkyl DNA adducts. AlkB has been reported to repair highly susceptible substrates, such as 1-methyladenine and 3-methylcytosine, more efficiently in ss ...
Bian, Ke +8 more
core +1 more source