Results 81 to 90 of about 14,917 (246)
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT The Ministerial Ordinance on Good Post‐Marketing Study Practice for Drugs was amended by the Ministry of Health, Labour and Welfare (MHLW) in 2018 to clearly define post‐marketing database studies (DBS) as a measure of pharmacovigilance activities for approved medical products in Japan.
Suguru Okami +2 more
wiley +1 more source
The biology of PKM2 in the metabolism and senescence in diabetic kidney disease
Journal of Diabetes Investigation, Volume 17, Issue 2, Page 197-204, February 2026.ABSTRACT Diabetic kidney disease (DKD) is one of the most common causes of chronic kidney disease that leads to end‐stage kidney disease, and its progression is closely linked to metabolic stress within renal tubular cells. Under long‐term hyperglycemia, cells shift their glucose metabolism from normal oxidative phosphorylation toward glycolysis.
Md. Imrul Kayes, Keizo Kanasaki
wiley +1 more source
Emerging methods for subtype differentiation in primary aldosteronism
Journal of Internal Medicine, Volume 299, Issue 2, Page 178-195, February 2026.Abstract Primary aldosteronism (PA) is a common cause of hypertension. Compared to patients with essential hypertension, untreated PA is associated with a two‐ to fourfold greater risk of cardiovascular disease, renal failure, and death. PA is caused by increased secretion of aldosterone from one adrenal gland in 30% of the patients and both adrenal ...
Oskar Ragnarsson +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan +6 more
wiley +1 more source
Learning Health Systems, Volume 10, Issue 1, January 2026.ABSTRACT Introduction Despite strong evidence supporting guideline‐directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF), a significant gap persists in the consistent application of these therapies. This shortfall has prompted organizations like the American College of Cardiology to recommend leveraging electronic ...
Joey LeGrand +5 more
wiley +1 more source
Alcohol, Clinical and Experimental Research, Volume 50, Issue 1, January 2026.The endocrine system coordinates whole body cellular function and maintains homeostasis. Alcohol impacts the integrity of endocrine regulation at multiple sites, contributing to risk for comorbidities. Some of the alcohol‐mediated pathophysiological effects on the endocrine system include alterations in receptor expression and responsiveness, protein ...
Patricia E. Molina, Liz Simon
wiley +1 more source
The Use of Tranexamic Acid to Treat Melasma: A Systematic Review and Meta‐Analysis
Dermatologic Therapy, Volume 2026, Issue 1, 2026.Introduction Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits bleeding due to its effects on plasminogen conversion, approved by the FDA to treat menorrhagia and prevent bleeding in hemophilia patients undergoing dental extraction.
Nabila Scabine Pessotti +7 more
wiley +1 more source
Catheterization and Cardiovascular Interventions, Volume 106, Issue 7, Page 3473-3480, December 1, 2025.ABSTRACT Aortic regurgitation (AR) develops in up to 25%−30% of patients with left ventricular assist device (LVAD). Treatment remains challenging since surgery confers significant peri‐operative risk and the lack of valvular calcification renders transfemoral transcatheter aortic valve implantation (TF‐TAVI) with non‐dedicated devices technically ...
Daniel Tai‐Leung Chan +9 more
wiley +1 more source
Willingness to pay for a reduction in the mortality risk after a myocardial infarction: an aplication of the contingent valuation method to the case of eplerenone [PDF]
Background: In order to allocate health care resources more efficiently it is necessary to relate health improvements provided by new medicines with their cost.
Jaime Fernández de Bobadilla +2 more
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Cost-Effectiveness of Eplerenone in Patients with Left Ventricular Dysfunction after Myocardial Infarction—An Analysis of the EPHESUS Study from a Swiss Perspective [PDF]
, 2018 Objective: The EPHESUS study demonstrated that aldosterone blockade with eplerenone decreased mortality in patients with left ventricular systolic dysfunction (LVSD) and heart failure after acute myocardial infarction (AMI).
Burnier, Michel +6 more
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