Results 81 to 90 of about 14,325 (202)

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm [PDF]

open access: yes, 2016
Many conditions culminate in heart failure (HF), a multi-organ systemic syndrome with an intrinsically poor prognosis. Pharmacotherapeutic agents that correct neurohormonal dysregulation and haemodynamic instability have occupied the forefront of ...
Abozguia   +119 more
core   +1 more source

An individual treatment effect approach to predict response to mineralocorticoid receptor antagonists in patients with heart failure and reduced ejection fraction

open access: yesEuropean Journal of Heart Failure, EarlyView.
Aims Mineralocorticoid receptor antagonists (MRAs) are often underused in patients with heart failure (HF) and reduced ejection fraction (HFrEF). Individual treatment effect (ITE) may assist physicians in making timely decisions about which patients are the best suited for personalized therapy.
Masatake Kobayashi   +9 more
wiley   +1 more source

European Journal of Heart Failure consensus statement. Heart failure pharmacotherapy for patients with heart failure with reduced ejection fraction and concomitant atrial fibrillation: Review of evidence and call to action

open access: yesEuropean Journal of Heart Failure, EarlyView.
Heart failure (HF) and atrial fibrillation (AF) are major global health challenges with rising prevalence and significant morbidity, mortality, and healthcare burden. Despite advances in HF management, AF remains a critical comorbidity that worsens outcomes and requires ad hoc treatment strategies, increasing the risk of non‐adherence and side effects.
Mark Luedde   +24 more
wiley   +1 more source

Urinary markers in heart failure – types, timing and thresholds. European Journal of Heart Failure expert consensus document

open access: yesEuropean Journal of Heart Failure, EarlyView.
Pathophysiologic mechanisms of heart failure (HF) (i.e. renin–angiotensin–aldosterone system [RAAS], congestion, and inflammation), together with patient‐related factors such as diabetes, hypertension, and chronic kidney disease (CKD), contribute to kidney function decline and glomerular or tubular injury.
Masatake Kobayashi   +14 more
wiley   +1 more source

Eplerenone-Mediated Aldosterone Blockade Prevents Renal Fibrosis by Reducing Renal Inflammation, Interstitial Cell Proliferation and Oxidative Stress

open access: yesKidney & Blood Pressure Research, 2013
Background/Aims: Prolonged elevation of serum aldosterone leads to renal fibrosis. Inflammation also plays a role in the pathogenesis of renal disease.
Hui Chen   +5 more
doaj   +1 more source

Eplerenone improves kidney function and cardiac performance in obese male mice

open access: yesDiabetic Medicine, EarlyView.
Abstract Aims Renin‐angiotensin‐aldosterone system (RAAS) activation mediates obesity‐associated cardiorenal dysfunction. Due to an incomplete understanding of the molecular mechanisms, the clinical use of RAAS antagonism in obesity‐associated cardiometabolic complications remains uncertain.
Ayman K. Banah   +8 more
wiley   +1 more source

Treatment of Heart Failure with Preserved Ejection Fraction [PDF]

open access: yes, 2011
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90240/1/phco.31.3.312 ...
Barnes, Megan M.   +4 more
core   +1 more source

Co‐Occurrence of Endogenous and Exogenous Cushing's Syndromes: Does “Double Cushing Syndrome” Really Exist? A Case Report

open access: yesClinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Double Cushing syndrome exists: exogenous steroid use can mask concurrent adrenal hypercortisolism. When symptoms persist and cortisol remains high after tapering or stopping prescribed glucocorticoids, an endogenous source is likely. Early recognition with ACTH testing, dexamethasone suppression, and adrenal imaging reduces misdiagnosis ...
Reza Amani‐Beni   +4 more
wiley   +1 more source

Endothelial Dysfunction in Human Essential Hypertension [PDF]

open access: yes, 2016
Although the endothelium has a number of important functions, the term endothelial dysfunction is commonly used to describe impairment in its vasodilatory capacity.
Akiyama   +137 more
core   +3 more sources

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