Results 71 to 80 of about 14,919 (226)

Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection

mBio, 2016
Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream.
Natalie J. Spillman, Varun K. Dalmia, Daniel E. Goldberg   +2 more
doaj   +1 more source

EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides

Journal of Lipid Research, 2012
Epoxide hydrolases are a small superfamily of enzymes important for the detoxification of chemically reactive xenobiotic epoxides and for the processing of endogenous epoxides that act as signaling molecules.
Martina Decker, Magdalena Adamska, Annette Cronin, Francesca Di Giallonardo, Julia Burgener, Anne Marowsky, John R. Falck, Christophe Morisseau, Bruce D. Hammock, Artiom Gruzdev, Darryl C. Zeldin, Michael Arand   +11 more
doaj   +1 more source

Soluble Epoxide Hydrolase

Asian Journal of Pharmaceutical Research and Development
Epoxyeicosatrienoic acids (EETs) have numerous cardiovascular benefits, including vasodilation, anti-inflammatory actions, and anti-migratory effects on vascular smooth muscle cells. However, sEH, an enzyme that breaks down EETs into diols, limits these benefits.
Pooja M. Sontakke, Suraj G. Malpani, Pooja R. Tange, MD Rayees Ahmad, Vishweshwar M. Dharashive   +4 more
openaire   +1 more source

Formation and metabolism in vitro of 5,6-epoxides of cholesterol and β-sitosterol

Journal of Lipid Research, 1974
The formation of 5α,6α- and 5β,6β-epoxides of cholesterol and β-sitosterol in rat liver subcellular fractions has been studied. The results show that the epoxidation seems to occur only in connection with the nonspecific tissue oxidation of the sterols ...
Leif Aringer, Peter Eneroth
doaj   +1 more source

Comprehensive analysis of the immune implication of EPHX4 gene in laryngeal squamous cell carcinoma

Brazilian Journal of Otorhinolaryngology
Objectives: The role of Epoxide Hydrolase-4 (EPHX4), a member of epoxide hydrolase family, has not been investigated in cancer. The purpose of this article is to explore the application value of EPHX4 in laryngeal cancer and its relationship with immune ...
Nimei Shen, Gang Gao, Xinhong Lu, Jiaxin Jin, Liwei Lin, Maohua Qian, Yang Qin   +6 more
doaj   +1 more source

Soluble epoxide hydrolase in the human placenta throughout gestation

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objective: To investigate the spatial and temporal changes of soluble epoxide hydrolase (sEH) in the human placenta throughout gestation and to study the effects of hypoxia-reoxygenation (HR) on the expression of sEH in villous explants in vitro ...
Tai-Ho Hung, Szu-Fu Chen, T'sang-T'ang Hsieh   +2 more
doaj   +1 more source

Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase and ethanolamides metabolism with Alzheimer’s disease [PDF]

, 2021
Kamil Borkowski, Theresa L. Pedersen, Nicholas T. Seyfried, James J. Lah, Allan I. Levey, Chadwick M. Hales, Eric B. Dammer, Colette Blach, Gregory Louie, Rima Kaddurah‐Daouk, John W. Newman   +10 more
openalex   +1 more source

Association between the soluble epoxide hydrolase gene and preeclampsia

Hypertension in Pregnancy, 2017
Objective: In this study the association between K55R polymorphism, methylation level of the EPHX2 promoter region, and PE was investigated in 520 individuals including 260 PE patients and 260 healthy pregnant women.
Ismail Sari, Hatice Pinarbasi, Ergun Pinarbasi, Caglar Yildiz   +3 more
doaj   +1 more source

Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity [PDF]

, 2019
Jiong Hu, Sofia‐Iris Bibli, Janina Wittig, Sven Zukunft, Jihong Lin, Hans‐Peter Hammes, Rüdiger Popp, Ingrid Fleming   +7 more
openalex   +1 more source

The Generation of a Nanobody-Based ELISA for Human Microsomal Epoxide Hydrolase [PDF]

, 2023
Qiyi He, Mark R. McCoy, Qi Meng, Christophe Morisseau, Huiyi Yang, Chengpeng Xu, Rachel Shey, Michael Goodman, Suqing Zhao, Bruce D. Hammock   +9 more
openalex   +1 more source