Biochemical and structural characterization of two cif-like epoxide hydrolases from Burkholderia cenocepacia [PDF]
Current Research in Structural Biology, 2021 Epoxide hydrolases catalyze the conversion of epoxides to vicinal diols in a range of cellular processes such as signaling, detoxification, and virulence. These enzymes typically utilize a pair of tyrosine residues to orient the substrate epoxide ring in
Noor M. Taher +8 more
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Epoxide Hydrolases: Multipotential Biocatalysts. [PDF]
Int J Mol Sci, 2023 Epoxide hydrolases are attractive and industrially important biocatalysts. They can catalyze the enantioselective hydrolysis of epoxides to the corresponding diols as chiral building blocks for bioactive compounds and drugs. In this review article, we discuss the state of the art and development potential of epoxide hydrolases as biocatalysts based on ...
Bučko M +4 more
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Structure-function relationship between soluble epoxide hydrolases structure and their tunnel network [PDF]
Computational and Structural Biotechnology Journal, 2022 Enzymes with buried active sites maintain their catalytic function via a single tunnel or tunnel network. In this study we analyzed the functionality of soluble epoxide hydrolases (sEHs) tunnel network, by comparing the overall enzyme structure with the ...
Karolina Mitusińska +7 more
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Gram-Scale Synthesis of (R)-P-Chlorophenyl-1,2-Ethanediol at High Concentration by a Pair of Epoxide Hydrolases [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 (R)-p-chlorophenyl-1,2-ethanediol (pCPED) is an important intermediate for the synthesis of (R)-eliprodil that is widely applied in the treatment of ischemic stroke.
Dong Zhang +5 more
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Cloning and Characterization of Drosophila melanogaster Juvenile Hormone Epoxide Hydrolases (JHEH) and Their Promoters [PDF]
Biomolecules, 2022 Juvenile hormone epoxide hydrolase (JHEH) plays an important role in the metabolism of JH III in insects. To study the control of JHEH in female Drosophila melanogaster, JHEH 1, 2 and 3 cDNAs were cloned and sequenced.
Dov Borovsky +6 more
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Evolution of tunnels in α/β-hydrolase fold proteins-What can we learn from studying epoxide hydrolases? [PDF]
PLoS Computational Biology, 2022 The evolutionary variability of a protein's residues is highly dependent on protein region and function. Solvent-exposed residues, excluding those at interaction interfaces, are more variable than buried residues whereas active site residues are ...
Maria Bzówka +7 more
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Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during
mBio, 2016 Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream.
Natalie J. Spillman +2 more
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The prognostic significance of epoxide hydrolases in colorectal cancer [PDF]
Biochemistry and Biophysics ReportsColorectal cancer (CRC) is a common malignant cancer. Epoxide hydrolases (EHs) are involved in the development of cancer by regulating epoxides, but their relationship with CRC is unclear.
Lichao Cao +5 more
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New Thermophilic α/β Class Epoxide Hydrolases Found in Metagenomes From Hot Environments [PDF]
Frontiers in Bioengineering and Biotechnology, 2018 Two novel epoxide hydrolases (EHs), Sibe-EH and CH65-EH, were identified in the metagenomes of samples collected in hot springs in Russia and China, respectively.
Erica Elisa Ferrandi +8 more
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Characterization of an isobutylene epoxide hydrolase (IbcK) from the isobutylene-catabolizing bacterium Mycolicibacterium sp. ELW1 [PDF]
Applied and Environmental MicrobiologyIsobutylene (IB) is produced on a large scale by the petrochemical industry and is metabolized by the aerobic alkene-metabolizing bacterium Mycolicibacterium sp. ELW1. The initial metabolite of IB catabolism by this bacterium is proposed to be 2-methyl-1,
Nicholas W. Faulkner +6 more
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