Results 61 to 70 of about 6,873 (191)

New High-Throughput Screening Assays for Biocatalysis

CHIMIA, 2001
High-throughput screening for catalysis is a critical technology in all experiments aimed at modifying or creating enzymes by directed evolution, as well as for biodiversity mining for new catalysts.
Jean-Louis Reymond
doaj   +2 more sources

Lipoprotein‐Mediated Esterified Oxylipins Changed in Alzheimer's Disease

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Inflammation is crucial in Alzheimer's Disease (AD) pathology, with oxylipins – oxidized lipid derivatives of polyunsaturated fatty acids – serving as potent modulators. Particularly, dysregulation of soluble epoxide hydrolase (sEH), which converts pro‐resolving epoxides to pro‐inflammatory diols, has been observed in blood and ...
Sitong Zhou, Kamil Borkowski, Angela M. Zivkovic, Izumi Maezawa, John W. Newman, Lee‐Way Jin   +5 more
wiley   +1 more source

Soluble epoxide hydrolase‐derived linoleic acid diols, cerebral small vessel disease markers and white matter microstructural integrity in type 2 diabetes mellitus

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background While polyunsaturated fatty acids can be metabolized into beneficial, anti‐inflammatory epoxides, they are subsequently converted to inactive, cytotoxic diols by soluble epoxide hydrolase (sEH). Increased linoleic acid (LA)‐derived diols have been associated with poorer cognitive performance in type 2 diabetes mellitus (T2DM ...
Si Won Ryoo, William Z. Lin, Myuri Ruthirakuhan, Yuen Yan Wong, Natasha Z. Anita, Malcolm Binns, Manuel Montero‐Odasso, Stephen R. Arnott, Carmela Tartaglia, Anthony E. Lang, Sean Symons, Robert A Hegele, Bradley J. MacIntosh, Krista L Lanctôt, Ameer Y. Taha, Sandra E. Black, Walter Swardfager   +16 more
wiley   +1 more source

Total plasma cytochrome P450‐soluble epoxide hydrolase oxylipins, apolipoprotein E ε4 carrier status, and white matter hyperintensities in cerebrovascular disease

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background The cytochrome P450‐soluble epoxide hydrolase (CYP450‐sEH) pathway has been implicated in cerebral small vessel disease (cSVD) due to the anti‐inflammatory and vasoactive effects of epoxide species produced by CYP450, which are converted into diols by sEH.
William Z. Lin, Si Won Ryoo, Alexandra Magliocco, Natasha Z. Anita, Myuri Ruthirakuhan, Celine H.L. Huang, Sofia Perfetto, Douglas P. Munoz, Angela C. Roberts, Malcolm Binns, Anthony E. Lang, Sean Symons, Ameer Y. Taha, Walter Swardfager   +13 more
wiley   +1 more source

Optimization of translation profiles enhances protein expression and solubility.

PLoS ONE, 2015
mRNA is translated with a non-uniform speed that actively coordinates co-translational folding of protein domains. Using structure-based homology we identified the structural domains in epoxide hydrolases (EHs) and introduced slow-translating codons to ...
Anne-Katrin Hess, Paul Saffert, Klaus Liebeton, Zoya Ignatova   +3 more
doaj   +1 more source

The Role and Therapeutic Potential of the cGAS‐STING Signaling Pathway in Alzheimer's Disease

Brain and Behavior, Volume 15, Issue 12, December 2025.
This work reveals the relationship between the cGAS‐STING signaling pathway and the pathological mechanisms of Alzheimer's disease.The role of the cGAS‐STING signaling pathway in AD pathology. AD leads to the production of neutrophil extracellular traps (NETs), endoplasmic reticulum (ER) stress, and the release of mitochondrial DNA (mtDNA) and nuclear ...
Xue Li, Wei Gao, Qiuyan Ye, Honglin Li
wiley   +1 more source

epoxide hydrolase

Citation: 'epoxide hydrolase' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.10676 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

Role of Soluble Epoxide Hydrolase in Metabolism of PUFAs in Psychiatric and Neurological Disorders

Frontiers in Pharmacology, 2019
Inflammation plays a key role in the pathogenesis of a number of psychiatric and neurological disorders. Soluble epoxide hydrolases (sEH), enzymes present in all living organisms, metabolize epoxy fatty acids (EpFAs) to corresponding 1,2-diols by the ...
Kenji Hashimoto
doaj   +1 more source

Drawing Links from Transcriptome to Metabolites: The Evolution of Aroma in the Ripening Berry of Moscato Bianco (Vitis vinifera L.)

Frontiers in Plant Science, 2017
Monoterpenes confer typical floral notes to “Muscat” grapevine varieties and, to a lesser extent, to other aromatic non-Muscat varieties. Previous studies have led to the identification and functional characterization of some enzymes and genes in this ...
Laura Costantini, Christian D. Kappel, Massimiliano Trenti, Juri Battilana, Francesco Emanuelli, Maddalena Sordo, Marco Moretto, Céline Camps, Roberto Larcher, Serge Delrot, Maria S. Grando, Maria S. Grando   +11 more
doaj   +1 more source

Soluble Epoxide Hydrolase

Asian Journal of Pharmaceutical Research and Development
Epoxyeicosatrienoic acids (EETs) have numerous cardiovascular benefits, including vasodilation, anti-inflammatory actions, and anti-migratory effects on vascular smooth muscle cells. However, sEH, an enzyme that breaks down EETs into diols, limits these benefits.
Pooja M. Sontakke, Suraj G. Malpani, Pooja R. Tange, MD Rayees Ahmad, Vishweshwar M. Dharashive   +4 more
openaire   +1 more source