Results 61 to 70 of about 3,161 (116)

Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid. [PDF]

J Biol Chem
Dong S, Xuan J, Feng Y, Cui Q.
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Metabolomics reveals soluble epoxide hydrolase as a therapeutic target for high-sucrose diet-mediated gut barrier dysfunction. [PDF]

Proc Natl Acad Sci U S A
Lin AZ, Fu X, Jiang Q, Zhou X, Hwang SH, Yin HH, Ni KD, Pan QJ, He X, Zhang LT, Meng YW, Liu YN, Hammock BD, Liu JY.   +13 more
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Soluble Epoxide Hydrolase Inhibition Attenuates Proteinuria by Alleviating Renal Inflammation and Podocyte Injuries in Adriamycin-Induced Nephropathy. [PDF]

Int J Mol Sci
Niu Q, Guo Z, Liang Y, Zuo L.
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Cytosolic epoxide hydrolase

Chemico-Biological Interactions, 1988
Epoxide hydrolase activity is recovered in the high-speed supernatant fraction from the liver of all mammals so far examined, including man. For some as yet unexplained reason, the rat has a very low level of this activity, so that cytosolic epoxide hydrolase is generally studied in mice.
Joseph W. DePierre, Johan Meijer
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The Telltale Structures of Epoxide Hydrolases

Drug Metabolism Reviews, 2003
Traditionally, epoxide hydrolases (EH) have been regarded as xenobiotic-metabolizing enzymes implicated in the detoxification of foreign compounds. They are known to play a key role in the control of potentially genotoxic epoxides that arise during metabolism of many lipophilic compounds.
Arand, Michael, Cronin, Annette, Oesch, Franz, Mowbray, Sherry L, Jones, T Alwyn   +4 more
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The interaction of cytosolic epoxide hydrolase with chiral epoxides

International Journal of Biochemistry, 1993
1. The kinetic parameters of the cytosolic epoxide hydrolase were examined with two sets of spectrophotometric substrates. The (2S,3S)- and (2R,3R)-enantiomers of 4-nitrophenyl trans-2,3-epoxy-3-phenylpropyl carbonate had a KM of 33 and 68 microns and a Vmax of 16 and 27 mumol/min/mg, respectively.
Bruce D. Hammock, Eric C. Dietze, Eiichi Kuwano   +2 more
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Stereoselectivities of microbial epoxide hydrolases

Current Opinion in Chemical Biology, 1999
Epoxide hydrolases from bacterial and fungal sources are highly versatile biocatalysts for the asymmetric hydrolysis of epoxides on a preparative scale. Besides kinetic resolution, which yields the corresponding enantiomerically enriched vicinal diol and the remaining nonconverted epoxide, enantioconvergent processes are also possible, which lead to ...
Romano V. A. Orru, Kurt Faber
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Converting an Esterase into an Epoxide Hydrolase

Angewandte Chemie International Edition, 2009
AbstractEntering the fold: A common structural motif in hydrolytic enzymes is the α,β‐hydrolase fold. The interconversion of one enzyme into another by introduction of mechanistically important residues is not enough; only substitution of a loop allows epoxide hydrolase activity in the esterase scaffold to be formed (see picture; structure comparison ...
Konstanze Stiba, Helge Jochens, Ryota Fujii, Christopher K. Savile, Romas J. Kazlauskas, Tatsiana Gerassenkov, Uwe T. Bornscheuer, Juin Guo Yu   +7 more
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Membrane topology of epoxide hydrolase

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
The amino acid sequences of epoxide hydrolase from rat, rabbit and human have been subjected to hydropathy analysis and a novel model for the membrane topology of this enzyme is presented. The enzyme would appear to be retained in microsomal membranes by a single transmembrane segment located at the N-terminus and the majority (96%) of the protein is ...
Michelle Lament, John A. Craft, Susan Baird, Brian Burchell   +3 more
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Synthetic applications of epoxide hydrolases

Current Opinion in Chemical Biology, 2001
There have been several recent advances in the area of biocatalysed hydrolytic kinetic resolution of epoxides using 'newly discovered' enzymes (i.e. epoxide hydrolases). These biocatalysts, two of which will become commercially available in the near future, appear to be highly promising tools for fine organic synthesis, as they enable the preparation ...
Roland Furstoss, Alain Archelas
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