Results 181 to 190 of about 2,734,900 (203)

Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function

Progress in Lipid Research, 2004
Epoxyeicosatrienoic acids (EETs), which are synthesized from arachidonic acid by cytochrome P450 epoxygenases, function primarily as autocrine and paracrine effectors in the cardiovascular system and kidney. They modulate ion transport and gene expression, producing vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects.
Arthur A, Spector, Xiang, Fang, Gary D, Snyder, Neal L, Weintraub   +3 more
openaire   +2 more sources

Chiral Resolution of the Epoxyeicosatrienoic Acids, Arachidonic Acid Epoxygenase Metabolites

Analytical Biochemistry, 2006
An HPLC method for the chiral analysis of the four regioisomeric epoxyeicosatrienoic acids (EETs) is described. The cytochrome P450 arachidonic acid epoxygenase metabolites are resolved, without the need for derivatization, by chiral-phase HPLC on a Chiralcel OJ column.
John R. Falck, Jorge H Capdevila, Kasem Nithipatikom   +2 more
exaly   +3 more sources

Effects of epoxyeicosatrienoic acids on polymorphonuclear leukocyte function

Life Sciences, 2002
During periods of ischemia and vascular injury, factors are released which recruit monocytes and polymorphonuclear leukocytes (PMNs) to the site of injury by promoting adherence to the endothelium and transmigration across the endothelial cell (EC) layer.
Phillip F, Pratt, Mark, Rosolowsky, William B, Campbell   +2 more
openaire   +2 more sources

Epoxyeicosatrienoic Acid Pathway in Human Health and Diseases

Journal of Cardiovascular Pharmacology, 2013
In response to endothelial cell activation, arachidonic acid can be converted by cytochrome P450 (CYP) epoxygenases to epoxyeicosatrienoic acids (EETs), which have potent vasodilator and anti-inflammatory properties. EETs are rapidly degraded in vivo to the less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).
Jeremy, Bellien, Robinson, Joannides
openaire   +2 more sources

Dual Regulation of the Cerebral Microvasculature by Epoxyeicosatrienoic Acids

Trends in Cardiovascular Medicine, 2001
Epoxyeicosatrienoic acids (EETs) are lipid metabolites that are synthesized in vascular endothelial cells. They are released by stimulation of their muscarinic receptors, and induce vaso-relaxation of cerebral blood vessels. In addition, cytochrome P450 epoxygenase enzymes, which catalyze the formation of epoxyeicosatrienoic acids, especially after ...
M, Medhora, J, Narayanan, D, Harder
openaire   +2 more sources

Determination of 14,15-Epoxyeicosatrienoic Acid and 14,15-Dihydroxyeicosatrienoic Acid by Fluoroimmunoassay

Analytical Biochemistry, 1997
A fluoroimmunoassay (FIA) for 14,15-epoxyeicosatrienoic acid (14,15-EET) and 14,15-dihydroxyeicosatrienoic acid (14,15-DHET), cytochrome P450 epoxygenase products of arachidonic acid, was developed using fluorescence polarization. 14-15-EET was hydrolyzed and analyzed as 14,15-DHET. 14,15-DHET was conjugated to thyroglobulin and a specific antibody was
K, Nithipatikom, J R, Falck, R K, Bhatt, C J, Hanke, W B, Campbell   +4 more
openaire   +2 more sources

Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
Epoxyeicosatrienoic acids, metabolites of the cytochrome P-450-mediated epoxygenase reaction, were detected in human urine by gas chromatographic-mass spectroscopic techniques after conversion to their hydrogenated and non-hydrogenated methyl and pentafluorobenzyl esters.
R, Toto, A, Siddhanta, S, Manna, B, Pramanik, J R, Falck, J, Capdevila   +5 more
openaire   +2 more sources

Is EDHF an epoxyeicosatrienoic acid?

Trends in Pharmacological Sciences, 2000
J, Quilley, J C, McGiff
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Formation and Mechanism of Action of Epoxyeicosatrienoic Acids

1989
Many biologically active eicosanoids originate from cyclooxygenase and lipoxygenase catalyzed metabolism of arachidonic acid (1). These substances include prostaglandins, thromboxanes, and leukotrienes. The enzymological features of their biosynthesis are characterized to a great extent.
openaire   +1 more source

Biosynthesis and Immunity of Epoxyeicosatrienoic Acids in a Lepidopteran Insect, Spodoptera exigua

Developmental and Comparative Immunology, 2020
Mohammad Vatanparast, Yonggyun Kim, Dong-Hee Lee   +2 more
exaly