Results 161 to 170 of about 2,734,900 (203)

Epoxyeicosatrienoic acid analogue mitigates kidney injury in a rat model of radiation nephropathy. [PDF]

Clin Sci (Lond), 2016
Hye Khan MA, Fish B, Wahl G, Sharma A, Falck JR, Paudyal MP, Moulder JE, Imig JD, Cohen EP.   +8 more
europepmc   +1 more source

Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension. [PDF]

J Hypertens, 2018
Červenka L, Husková Z, Kopkan L, Kikerlová S, Sedláková L, Vaňourková Z, Alánová P, Kolář F, Hammock BD, Hwang SH, Imig JD, Falck JR, Sadowski J, Kompanowska-Jezierska E, Neckář J.   +14 more
europepmc   +1 more source

Sexually dimorphic adaptation of cardiac function: roles of epoxyeicosatrienoic acid and peroxisome proliferator-activated receptors. [PDF]

Physiol Rep, 2016
Qin J, Le Y, Froogh G, Kandhi S, Jiang H, Luo M, Sun D, Huang A.   +7 more
europepmc   +1 more source

Correction: Untargeted metabolomics reveals distinct metabolic profiles in MUT-type methylmalonic acidemia. [PDF]

Mol Cell Pediatr
Alsuhaymi S, AlMalki RH, Al Mogren M, Alodaib A, Emwas AH, Dasouki M, Alfares A, Jaremko M, Abdel Rahman AM.   +8 more
europepmc   +1 more source

Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1α via downregulation of prolyl hydroxylase 3.

Am J Physiol Heart Circ Physiol, 2018
Neckář J, Hsu A, Hye Khan MA, Gross GJ, Nithipatikom K, Cyprová M, Benák D, Hlaváčková M, Sotáková-Kašparová D, Falck JR, Sedmera D, Kolář F, Imig JD.   +12 more
europepmc   +1 more source

Cyclooxygenase-Derived Proangiogenic Metabolites of Epoxyeicosatrienoic Acids [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance This study furthers our understanding of epoxyeicosatrienoic acid metabolism by cyclooxygenase (COX) enzymes as a physiologically relevant metabolic pathway, producing signaling molecules that are angiogenic. It explains, in part, why inhibiting the soluble epoxide hydrolase (sEH) in some systems is angiogenic whereas ...
Christophe Morisseau, Tomáš Čajka, Bruce D. Hammock   +2 more
exaly   +7 more sources

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Role of epoxyeicosatrienoic acids in the lung

Prostaglandins & Other Lipid Mediators, 2020
Epoxyeicosatrienoic acids (EETs) are synthetized from arachidonic acid by the action of members of the CYP2C and CYP2J subfamilies of cytochrome P450 (CYPs). The effects of EETs on cardiovascular function, the nervous system, the kidney and metabolic disease have been reviewed. In the lungs, the presence of these CYPs and EETs has been documented.
Hugo F, Olivares-Rubio, J J, Espinosa-Aguirre   +1 more
openaire   +2 more sources

The Role of Epoxyeicosatrienoic Acids in the Cardiovascular System [PDF]

British Journal of Clinical Pharmacology, 2015
There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors.
Joseph Cheriyan, Kaisa M Mäki-Petäjä, I B Wilkinson   +2 more
exaly   +4 more sources

Neuroprotective effects of epoxyeicosatrienoic acids

Prostaglandins & Other Lipid Mediators, 2018
Eicosatrienoic acids (EETs) are a class of intermediates produced during arachidonic acid metabolism mediated by cytochrome P450 epoxygenases that exert multiple physiological effects on the nervous system. EETs promote three metabolic processes, including esterification, hydrolysis and degradation or extension.
Lai, Wang, Gan, Luo, Long-Fei, Zhang, Hui-Xia, Geng   +3 more
openaire   +2 more sources

Epoxyeicosatrienoic Acids and Glucose Homeostasis in Mice and Men [PDF]

Prostaglandins and Other Lipid Mediators, 2016
Epoxyeicosatrienoic acids (EETs) are formed from arachidonic acid by the action of P450 epoxygenases (CYP2C and CYP2J). Effects of EETs are limited by hydrolysis by soluble epoxide hydrolase to less active dihydroxyeicosatrienoic acids. Studies in rodent models provide compelling evidence that epoxyeicosatrienoic acids exert favorable effects on ...
Nancy J. Brown, James M. Luther
exaly   +3 more sources