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Is EDHF an epoxyeicosatrienoic acid?
Trends in Pharmacological Sciences, 2000J, Quilley, J C, McGiff
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Formation and Mechanism of Action of Epoxyeicosatrienoic Acids
1989Many biologically active eicosanoids originate from cyclooxygenase and lipoxygenase catalyzed metabolism of arachidonic acid (1). These substances include prostaglandins, thromboxanes, and leukotrienes. The enzymological features of their biosynthesis are characterized to a great extent.
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Mechanisms of epoxyeicosatrienoic acid-induced cardioprotection
2012Ischemic heart disease remains a major cause of illness, disability and death worldwide, as such there remains a need for novel pharmacological agents that protect against myocardial ischemia reperfusion (I/R) injury. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase metabolites of arachidonic acid, which have demonstrated ...
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