Results 131 to 140 of about 5,105 (168)
Possible role of Epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disorders. [PDF]
Med Hypotheses, 2016 Lakkappa N +4 more
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Epoxyeicosatrienoic Acid as Therapy for Diabetic and Ischemic Cardiomyopathy
Trends in Pharmacological Sciences, 2016Cardiovascular disease remains the leading cause of death worldwide. Among many potential targets for pharmacological intervention, a promising strategy involves epoxyeicosatrienoic acid (EET) and soluble epoxide hydroxylase (sEH) inhibition. sEH is the enzyme that converts EET to its less potent metabolite; therefore, EET is upregulated by its ...
Nader Abraham, John A Mcclung
exaly +3 more sources
Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites
Analytical Biochemistry, 2006An HPLC method for the chiral analysis of the four regioisomeric epoxyeicosatrienoic acids (EETs) is described. The cytochrome P450 arachidonic acid epoxygenase metabolites are resolved, without the need for derivatization, by chiral-phase HPLC on a Chiralcel OJ column.
J R Falck +2 more
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Potentiation of Endothelium-Dependent Relaxation by Epoxyeicosatrienoic Acids
Circulation Research, 1997AbstractEpoxyeicosatrienoic acids (EETs) are potent endothelium-derived vasodilators formed from cytochrome P-450 metabolism of arachidonic acid. EETs and their diol products (DHETs) are also avidly taken up by endothelial cells and incorporated into phospholipids that participate in signal transduction.
Neal Weintraub +2 more
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Role of epoxyeicosatrienoic acids in the lung
Prostaglandins & Other Lipid Mediators, 2020Epoxyeicosatrienoic acids (EETs) are synthetized from arachidonic acid by the action of members of the CYP2C and CYP2J subfamilies of cytochrome P450 (CYPs). The effects of EETs on cardiovascular function, the nervous system, the kidney and metabolic disease have been reviewed. In the lungs, the presence of these CYPs and EETs has been documented.
Hugo F, Olivares-Rubio +1 more
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Neuroprotective effects of epoxyeicosatrienoic acids
Prostaglandins & Other Lipid Mediators, 2018Eicosatrienoic acids (EETs) are a class of intermediates produced during arachidonic acid metabolism mediated by cytochrome P450 epoxygenases that exert multiple physiological effects on the nervous system. EETs promote three metabolic processes, including esterification, hydrolysis and degradation or extension.
Lai, Wang +3 more
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Analytical Biochemistry, 1991
Four isomers of epoxyeicosatrienoic acid (EET) can be formed by cytochrome P-450 oxidation of arachidonic acid: 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid. The collision-induced dissociation of the [M-H]- anion at m/z 319 from each of these isomers, using negative-ion fast atom bombardment ionization and a triple quadrupole mass ...
K, Bernstrom, K, Kayganich, R C, Murphy
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Four isomers of epoxyeicosatrienoic acid (EET) can be formed by cytochrome P-450 oxidation of arachidonic acid: 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid. The collision-induced dissociation of the [M-H]- anion at m/z 319 from each of these isomers, using negative-ion fast atom bombardment ionization and a triple quadrupole mass ...
K, Bernstrom, K, Kayganich, R C, Murphy
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Action of epoxyeicosatrienoic acids on cellular function
American Journal of Physiology-Cell Physiology, 2007Epoxyeicosatrienoic acids (EETs), which function primarily as autocrine and paracrine mediators in the cardiovascular and renal systems, are synthesized from arachidonic acid by cytochrome P-450 epoxygenases. They activate smooth muscle large-conductance Ca2+-activated K+ channels, producing hyperpolarization and vasorelaxation.
Arthur A, Spector, Andrew W, Norris
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Influence of epoxyeicosatrienoic acids on uterine function
Prostaglandins, Leukotrienes and Essential Fatty Acids, 1997In spite of the large quantities of epoxyeicosatrienoic acids (EEts) released by reproductive tissues, their function has not yet been determined. In order to analyze the influence of epoxygenase products on isolated uterine function, Clotrimazole, a cytochrome P450 inhibitor was used. The drug decreased isolated rat uterine isometric developed tension
E, Gonzalez +3 more
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