Results 111 to 120 of about 2,734,900 (203)

Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase

, 2003
Three genes cloned from Fundulus heteroclitus (killifish) define a new P450 subfamily, CYP2P. Structurally, the CYP2Ps are related to fish CYP2Ns and mammalian CYP2Js. CYP2P transcripts are expressed predominantly in liver and intestine.
Oleksiak, Marjorie F, Wu, Shu, Qu, Wei, Cox, Rachel, Stegeman, John J, Zeldin, Darryl C, Parker, Carol   +6 more
core   +1 more source

14,15-Epoxyeicosatrienoic acid inhibits prostaglandin E₂production in vascular smooth muscle cells

, 1998
14,15-Epoxyeicosatrienoic acid (EET), a cytochrome P-450 epoxygenase product of arachidonic acid (AA), reduced PGE2formation by 40–75% in porcine aortic and murine brain microvascular smooth muscle cells.
Terry L. Kaduce, Steven A. Moore, Neal L. Weintraub, Lynn L. Stoll, Xiang Fang, Gretchen Rich, Arthur A. Spector   +6 more
core   +1 more source

Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease [PDF]

, 2010
Epoxyeicotrienoic acids (EETs) are cytochrome P450-dependent anti-hypertensive and anti-inflammatory derivatives of arachidonic acid, which are highly abundant in the kidney and considered reno-protective.
Geisslinger, Gerd, Gerd Geisslinger, Tsai, Cindy, Ralf P. Brandes, Brandes, Ralf, Schäfer, Liliana, Amann Kerstin, Liliana Schaefer, Kerstin Amann, Felix Jansen, Jung, Oliver, Ralf P Brandes, Mieth Anja, Hwang Sung H., Schaefer Liliana, Anja Mieth, Hwang, Sung H., Barbosa-Sicard Eduardo, Sung H. Hwang, Bruce D. Hammock, Hammock Bruce D., Christophe Morisseau, Cindy Tsai, Rainer U. Pliquett, Oliver Jung, Brandes Ralf P., Pliquett Rainer U., Mieth, Anja, Babelova, Andrea, Barbosa Sicard, Eduardo, Geisslinger Gerd, Jansen, Felix, Andrea Babelova, Sung H Hwang, Morisseau, Christophe, Pliquett, Rainer U., Eduardo Barbosa-Sicard, Jung Oliver, Rainer U Pliquett, Bruce D Hammock, Jansen Felix, Tsai Cindy, Morisseau Christophe, Amann, Kerstin, Hammock, Bruce D., Babelova Andrea   +45 more
core   +2 more sources

Orally active epoxyeicosatrienoic acid analogs in hypertension and renal injury. [PDF]

Adv Pharmacol, 2022
Imig JD.
europepmc   +1 more source

Arachidonic acid (ARA) pathway.

, 2018
ARA is metabolized by three enzyme families, cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP450), to produce numerous bioactive metabolites called oxylipins. Enzymes are shown in grey boxes.
Bruce D. Hammock (65754), Jessica A. Martinez (2297254), Denise J. Roe (429202), Jun Yang (2084), David S. Alberts (3024495), Patricia A. Thompson (209907), Betsy C. Wertheim (5146601), Peter Lance (198534), Alexander Schriewer (4184308)   +8 more
core   +1 more source

Epoxyeicosatrienoic Acid and Prostanoid Crosstalk at the Receptor and Intracellular Signaling Levels to Maintain Vascular Tone. [PDF]

Int J Mol Sci, 2022
Malacarne PF, Bezzenberger J, Lopez M, Warwick T, Müller N, Brandes RP, Rezende F.   +6 more
europepmc   +1 more source

11,12 Epoxyeicosatrienoic Acid Rescues Deteriorated Wound Healing in Diabetes. [PDF]

Int J Mol Sci, 2021
Sommer K, Jakob H, Reiche C, Henrich D, Sterz J, Frank J, Marzi I, Sander AL.   +7 more
europepmc   +1 more source

CYP2C19 Contributes to THP-1-Cell-Derived M2 Macrophage Polarization by Producing 11,12- and 14,15-Epoxyeicosatrienoic Acid, Agonists of the PPARγ Receptor. [PDF]

Pharmaceuticals (Basel), 2023
Cho HY, Ahn S, Cho YS, Seo SK, Kim DH, Shin JG, Lee SJ.   +6 more
europepmc   +1 more source

Epoxyeicosatrienoic Acids and 20-Hydroxyeicosatetraenoic Acid on Endothelial and Vascular Function [PDF]

, 2016
Endothelial and vascular smooth cells generate cytochrome P450 (CYP) arachidonic acid metabolites that can impact endothelial cell function and vascular homeostasis. The objective of this review is to focus on the physiology and pharmacology of endothelial CYP metabolites.
openaire   +2 more sources

Flicker light-induced retinal vasodilation is unaffected by inhibition of epoxyeicosatrienoic acids and prostaglandins in humans

, 2014
Flicker light-induced retinal vasodilation is unaffected by inhibition of epoxyeicosatrienoic acids and prostaglandins in ...
GJ Dusting (15839609), Dan Dias (14681695), U Roessner (9724625), AJ Jenkins (10085956), REK Man (14548985), EL Lamoureux (14448384), WJ Best (17367439), TT Nguyen (7792223), NS Jayasinghe (9887186), JE Noonan (17367436)   +9 more
core   +1 more source