Results 101 to 110 of about 2,734,900 (203)

Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase [PDF]

, 2014
Soluble epoxide hydrolase (sEH) is inhibited by electrophilic lipids by their adduction to Cys521 proximal to its catalytic center. This inhibition prevents hydrolysis of the enzymes' epoxyeicosatrienoic acid (EET) substrates, so they accumulate inducing
Hammock, Bruce D, Yang, Jun, Eaton, Philip, Charles, Rebecca L, Freeman, Bruce A., Freeman, Bruce A, Kamynina, Alisa, Morisseau, Christophe, Prysyazhna, Oleksandra, Eaton, Philip; id_orcid, Rudyk, Olena, Charles, Rebecca L., Hammock, Bruce D., Rudyk, Olena; id_orcid   +13 more
core   +1 more source

The effects of CYP450 inhibition on cerebrovascular control during rest and mild hypovolemia: An exploratory study in young, healthy adults

Physiological Reports
Cerebrovascular CYP450 is underexplored in humans. Twenty‐three participants (12 females) completed familiarization and two experimental visits utilizing double‐blind, randomized, crossover design.
Jacob E. Matney, Alexander A. Buelow, Chris Mixon, Sarah M. Skillett, John D. Ashley, Jiwon Song, Amir Akbari Fakhrabadi, Paige Pointer, Justin D. Sprick, Christopher D. Black, Hugo M. Pereira, J. Mikhail Kellawan   +11 more
doaj   +1 more source

Development of UPLC-MS/MS methods for quantitation of glutathione, cysteine, 14,15-epoxyeicosatrienoic acid, and 15-hydroxyeicosatetraenoic acid and application in paraquat poisoning cells

, 2023
Glutathione (GSH) and cysteine are important antioxidants in maintaining the oxidation-reduction balance. 14,15-epoxyeicosatrienoic acid (14,15-EET) and 15-hydroxyeicosatetraenoic acid (15-HETE) are biological active compounds metabolized from ...
Zhongqiu Lu (839444), Jianhui Yang (536606), Congrong Tang (16370761), Xiaofang Ke (16370764), Lufeng Hu (829769), Xingjie Zhu (8898557), Zheng Yu (484983)   +6 more
core   +1 more source

Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function

Journal of Lipid Research, 2018
Lipoxygenase (LOX)-catalyzed oxidation of the essential fatty acid, linoleate, represents a vital step in construction of the mammalian epidermal permeability barrier.
Haruto Yamanashi, William E. Boeglin, Christophe Morisseau, Robert W. Davis, Gary A. Sulikowski, Bruce D. Hammock, Alan R. Brash   +6 more
doaj   +1 more source

Der Epoxyeicosatrienoic acid Stoffwechselweg verstärkt hepatisches Insulinsignaling und ist bei Hochfettdiät induzierter hepatischer Insulinresistenz reprimiert

, 2016
Hepatic insulin resistance is a hallmark of type 2 diabetes. I conducted quantitative proteomic profiling of liver tissue in a high fat diet (HFD) mouse model of hepatic insulin resistance.
Schäfer, Alexander
core  

The biological actions of 11,12-epoxyeicosatrienoic acid in endothelial cells are specific to the R/S-enantiomer and require the G(s) protein

, 2014
Cytochrome P450-derived epoxides of arachidonic acid [i.e., the epoxyeicosatrienoic acids (EETs)] are important lipid signaling molecules involved in the regulation of vascular tone and angiogenesis.
Popp, R., Ding, Y., Schunck, W.H., Froemel, T., Falck, J.R., Fleming, I.   +5 more
core   +1 more source

Comparison of the relative levels^a of metabolites of the arachidonic acid pathway in sera from BT and LL patients before and after antibiotic treatment.

, 2013
aAbsent values were substituted with the limit of detection, represented by the lowest intensity value of any given sample. Then, averaged values from the untreated BT serum samples (n = 4) were normalized to 100% and other samples were normalized ...
B. Brett Finlay (53559), Cristiana S. de Macedo (446238), Euzenir N. Sarno (157005), Maria das Graças M. O. Henriques (446242), Katherine A. Mattos (446239), Marcelo Ribeiro-Alves (184765), Jun Han (231645), André L. P. Candéa (446241), Julio J. Amaral (446236), Luis Caetano M. Antunes (446237), Christoph H. Borchers (159697), Jingxi Pan (446240), Maria Cristina V. Pessolani (446243), Patrícia T. Bozza (810038)   +13 more
core   +1 more source

Structural of PPARα ligands.

, 2016
(A) Comparison of structures of WY 14, 643, fenofibrate and bilirubin. (B) Arachidonic acid is the precursor for CYP epoxygenase (2C and 2J) production of 5,6-, 8,9-, 11,12-, and 14, 15- epoxyeicosatrienoic acids (EETs).
David E. Stec (2607871), Justin Baum (2607880), Michael W. Hankins (2607868), Amarjit Luniwal (2169016), Terry D. Hinds Jr. (2607877), Christopher J. Trabbic (1860355), Kezia John (2607874)   +6 more
core   +1 more source

CYP2C19 variants and epoxyeicosatrienoic acids in patients with microvascular angina

International Journal of Cardiology: Heart & Vasculature, 2017
Background: Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease.
Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Noriaki Tabata, Seiji Takashio, Yasuhiro Izumiya, Eiichiro Yamamoto, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Ayami Kajiwara, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Seiji Hokimoto   +15 more
doaj   +1 more source

Epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid, and renal microvascular function [PDF]

Prostaglandins & Other Lipid Mediators, 2013
The development of pharmacological, genetic, and biochemical tools have allowed for detailed studies to determine the contribution of cytochrome P450 (CYP) metabolites of arachidonic acid to renal microvascular function. Renal microvessels can generate CYP hydroxylase metabolites including 20-hydroxyeicosatetraenoic acid (20-HETE) and CYP epoxygenase ...
openaire   +2 more sources