Results 91 to 100 of about 2,734,900 (203)

Synthesis of 14,15-EET from Arachidonic Acid Using Urea–Hydrogen Peroxide as the Oxidant

, 2014
14,15- Epoxyeicosatrienoic acid (14,15-EET) is an endogenous bioactive lipid with pharmacological benefits in multiple cardiovascular diseases. We describe here a practical synthesis of 14,15-EET from arachidonic acid using urea–hydrogen peroxide (UHP ...
Fuchun Xie (627778), Bingbing X. Li (627779), Xiangshu Xiao (627781), Nabil J. Alkayed (400784)   +3 more
core   +1 more source

EICOSANOIDS AND INFLAMMATION

Современная ревматология, 2016
Inflammation is the most important element in the pathogenesis of major human diseases. It determines the fundamental value of anti-inflammatory therapy in the modern concept of targeted pathogenetic treatment.
A. E. Karateev, T. L. Aleinikova
doaj   +1 more source

Ya‐Jie‐Sha‐Ba Decoction Regulates Arachidonic Acid Metabolism to Treat Alcohol‐Associated Liver Disease by Activating PPARα–CYP4A14 Axis: Insights From Multi‐Omics Analysis and Experimental Validations

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Ya‐Jie‐Sha‐Ba decoction (YJSB), a traditional Dai medicinal formulation, has been widely used by the Dai ethnic group and has shown efficacy in alleviating alcohol‐associated liver disease (ALD). However, the molecular mechanism of YJSB in the management of ALD remains unclear.
Dehong Ma, Xia Chen, Huixian Dao, Hongyu Deng, Yingcheng Guo, Hui Yang, Yuanyuan Chen, Congmei Zhang, Yuan Long, Weibo Wen, Yinghong Zhao, Huantian Cui   +11 more
wiley   +1 more source

8C.05: EPOXYEICOSATRIENOIC ACIDS ARE INCREASED IN PLACENTAS OF PREECLAMPTIC PREGNANCIES

, 2015
Plasma concentration of epoxyeicosatrienoic acids (EETs) derived from cytochrome P450 (CYP)-dependent metabolism of arachidonic acid is increased in women with preeclampsia (PE) as compared to normal pregnancy (N), and is even higher in fetal plasma ...
Jiang, H, FAVA, Cristiano, Dalle Vedove, F., ZANCONATO, Giovanni, VATTEMI, Gaetano Nicola, BRUNELLI, Matteo, MINUZ, Pietro, Quilley, J   +7 more
core   +1 more source

Epoxyeicosatrienoic acids protect pancreatic beta cells against pro-inflammatory cytokine toxicity [PDF]

, 2019
Pro-inflammatory cytokines contribute to pancreatic beta cell death in the pathogenesis of type 1 diabetes mellitus (DM). Cytochrome P450-derived epoxyeicosatrienoic acids (EETs), produced by selective epoxidation of arachidonic acid, display anti ...
Watson
core   +1 more source

The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS

Journal of Lipid Research, 2002
A method for the simultaneous quantification of urinary linoleic and arachidonic acid derived epoxides and diols, as well as the arachidonate omega hydroxylated product has been developed. The method employs negative mode electrospray ionization and HPLC
John W. Newman, Takaho Watanabe, Bruce D. Hammock   +2 more
doaj   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid

, 1993
Metabolites of arachidonic acid regulate several physiological processes, including vascular tone. The purpose of this study was to determine which metabolites of arachidonic acid are produced by bovine coronary arteries and which may regulate coronary ...
M. Rosolowsky, W. B. Campbell
core   +1 more source

EETs modulate NF-κB signaling and alleviate STZ-induced chronic inflammation in type 2 diabetes [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Epoxyeicosatrienoic acids (EETs) have shown preventive effects against various metabolic diseases. The objective of this study was to investigate the effects and mechanisms of EETs onT2DM in rats. The rats were divided into an T2DM group and intervention
Haoyu Bai, Zhijun Guo, Ziyi Li, Chaoqun Liu, Boke Sun, Zhifeng Xie, Siriguleng Yu   +6 more
doaj   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source