Results 141 to 150 of about 5,105 (168)

Erythrocyte-derived epoxyeicosatrienoic acids

Prostaglandins & Other Lipid Mediators, 2007
Red blood cells (RBCs) are reservoirs for cis- and trans-epoxyeicosatrienoic acids (EETs) that can be released. The sources of EET release from RBCs include direct synthesis from arachidonic acid, peroxidation of phospholipids and EETs esterified into cellular phospholipids. The release of EETs from RBCs can be through cytosolic phospholipase A2 (PLA2),
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Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension

Current Opinion in Nephrology and Hypertension, 2004
Cytochrome P-450 metabolites of arachidonic acid have been reported to play an important role in the control of renal function and vascular tone, and in the long-term control of arterial pressure. In this regard, 20-hydroxyeicosatetraenoic acid is a potent vasoconstrictor that inhibits sodium reabsorption in the kidney.
Albert, Sarkis, Bernardo, Lopez, Richard J, Roman   +2 more
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20-Hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids and blood pressure

Current Opinion in Nephrology and Hypertension, 2001
The properties of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids, vasoactivity and modulation of ion transport and mediation/modulation of the effects of vasoactive hormones, such as angiotensin II and endothelin, underscore their importance to renal vascular mechanisms and electrolyte excretion.
J C, McGiff, J, Quilley
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Epoxyeicosatrienoic acids, cell signaling and angiogenesis

Prostaglandins & Other Lipid Mediators, 2007
Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases the expression of which is determined by hemodynamic and pharmacological stimuli as well as by hypoxia. The activation of CYP epoxygenases in endothelial cells is an important step in the vasodilatation that has been attributed to the endothelium ...
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Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function

Progress in Lipid Research, 2004
Epoxyeicosatrienoic acids (EETs), which are synthesized from arachidonic acid by cytochrome P450 epoxygenases, function primarily as autocrine and paracrine effectors in the cardiovascular system and kidney. They modulate ion transport and gene expression, producing vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects.
Arthur A, Spector, Xiang, Fang, Gary D, Snyder, Neal L, Weintraub   +3 more
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Effects of epoxyeicosatrienoic acids on polymorphonuclear leukocyte function

Life Sciences, 2002
During periods of ischemia and vascular injury, factors are released which recruit monocytes and polymorphonuclear leukocytes (PMNs) to the site of injury by promoting adherence to the endothelium and transmigration across the endothelial cell (EC) layer.
Phillip F, Pratt, Mark, Rosolowsky, William B, Campbell   +2 more
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Epoxyeicosatrienoic Acid Pathway in Human Health and Diseases

Journal of Cardiovascular Pharmacology, 2013
In response to endothelial cell activation, arachidonic acid can be converted by cytochrome P450 (CYP) epoxygenases to epoxyeicosatrienoic acids (EETs), which have potent vasodilator and anti-inflammatory properties. EETs are rapidly degraded in vivo to the less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).
Jeremy, Bellien, Robinson, Joannides
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Dual Regulation of the Cerebral Microvasculature by Epoxyeicosatrienoic Acids

Trends in Cardiovascular Medicine, 2001
Epoxyeicosatrienoic acids (EETs) are lipid metabolites that are synthesized in vascular endothelial cells. They are released by stimulation of their muscarinic receptors, and induce vaso-relaxation of cerebral blood vessels. In addition, cytochrome P450 epoxygenase enzymes, which catalyze the formation of epoxyeicosatrienoic acids, especially after ...
M, Medhora, J, Narayanan, D, Harder
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Determination of 14,15-Epoxyeicosatrienoic Acid and 14,15-Dihydroxyeicosatrienoic Acid by Fluoroimmunoassay

Analytical Biochemistry, 1997
A fluoroimmunoassay (FIA) for 14,15-epoxyeicosatrienoic acid (14,15-EET) and 14,15-dihydroxyeicosatrienoic acid (14,15-DHET), cytochrome P450 epoxygenase products of arachidonic acid, was developed using fluorescence polarization. 14-15-EET was hydrolyzed and analyzed as 14,15-DHET. 14,15-DHET was conjugated to thyroglobulin and a specific antibody was
K, Nithipatikom, J R, Falck, R K, Bhatt, C J, Hanke, W B, Campbell   +4 more
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Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
Epoxyeicosatrienoic acids, metabolites of the cytochrome P-450-mediated epoxygenase reaction, were detected in human urine by gas chromatographic-mass spectroscopic techniques after conversion to their hydrogenated and non-hydrogenated methyl and pentafluorobenzyl esters.
R, Toto, A, Siddhanta, S, Manna, B, Pramanik, J R, Falck, J, Capdevila   +5 more
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